French women, fractures and aortic calcifications

Rajzbaum, G.; Roger, VÃ©ronique L.; Bézie, Yvonnick; Chauffert, M; Breville, P.; Roux, Franck‐Emmanuel; Safar, M; Blacher, J.

doi:10.1111/j.1365-2796.2004.01430.x

Cited by 22 publications

(24 citation statements)

References 5 publications

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“…Cross-sectional studies were focused on vertebral fractures. Severe AAC was associated with greater prevalence, higher number and greater severity of vertebral fractures (11,(14)(15)(16)(17)(18)(19)(20)(21)(22). This association remained significant after adjustment for confounders including bone mineral density (BMD) measured by DXA.…”

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confidence: 69%

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Vascular calcification and fracture risk

Szulc

2015

ccmbm

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SummaryOsteoporosis and cardiovascular diseases are public health problems. Fragility fractures are associated with high risk of cardiovascular event and patients with cardiovascular diseases have higher risk of fracture. Severe abdominal aortic calcification (AAC) is associated with higher cardiovascular mortality and morbidity. Severe AAC is associated with higher risk of fracture. In cross-sectional studies severe AAC was associated with greater prevalence, higher number and greater severity of vertebral fractures after adjustment for confounders including bone mineral density (BMD). Prospective studies confirm the association between baseline AAC severity and prospectively assessed fracture risk in both sexes. Data on the link between AAC and BMD are discordant. Age, smoking, hypertension, diabetes mellitus, and low grade systemic inflammation are possible risk factors of severe AAC and fracture risk. However, in clinical studies, the link between AAC and fracture was significant after adjustment for these factors. Data on the association between calcification in other vascular beds and BMD are limited and discordant.

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confidence: 69%

“…Severe AAC and lower BMD were jointly and independently associated with higher number and greater severity of vertebral fractures (14,16). In some cohorts, severe AAC was also associated with prior hip fracture (11,22). Prospective studies assessed the association between baseline AAC severity and prospectively assessed risk of fracture.…”

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confidence: 99%

Vascular calcification and fracture risk

Szulc

2015

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“…Severe AAC may be associated with specific fracture types such as major fragility fractures (e.g. vertebra, hip), but not with other non-vertebral fractures (5,11–12). Thus, the association may be non-significant in younger cohorts composed mainly of subjects with mild AAC and few fracture events.…”

Section: Introductionmentioning

confidence: 99%

Abdominal aortic calcification and risk of fracture among older women — The SOF study

Szulc

Blackwell

Kiel

et al. 2015

Bone

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Data concerning the link between severity of abdominal aortic calcification (AAC) and fracture risk in postmenopausal women are discordant. This association may vary by skeletal site and duration of follow-up. Our aim was to assess the association between the AAC severity and fracture risk in older women over the short- and long-term. This is a case-cohort study nested in a large multicenter prospective cohort study. The association between AAC and fracture was assessed using Odds Ratios (OR) and 95% confidence intervals (95%CI) for vertebral fractures and using Hazard Risks (HR) and 95%CI for non-vertebral and hip fractures. AAC severity was evaluated from lateral spine radiographs using Kauppila’s semiquantitative score. Severe AAC (AAC score 5+) was associated with higher risk of vertebral fracture during 4 years of follow-up, after adjustment for confounders (age, BMI, walking, smoking, hip bone mineral density, prevalent vertebral fracture, systolic blood pressure, hormone replacement therapy) (OR=2.31, 95%CI: 1.24–4.30, p<0.01). In a similar model, severe AAC was associated with an increased in the hip fracture risk (HR=2.88, 95%CI: 1.00–8.36, p=0.05). AAC was not associated with the risk of any non-vertebral fracture. AAC was not associated with the fracture risk after 15-years of follow-up. In elderly women, severe AAC is associated with higher short-term risk of vertebral and hip fractures, but not with the long-term risk of these fractures. There is no association between AAC and risk of non-vertebral-non-hip fracture in older women. Our findings lend further support to the hypothesis that AAC and skeletal fragility are related.

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“…(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) Most previous studies have been cross-sectional analyses of postmenopausal women. (5)(6)(7)11,18,20,(26)(27)(28)(29)(30)(31)(32)(33) A few have been longitudinal, but examined women selected for the presence of one of these disorders or referred for clinical testing, based presumably on suggestive symptoms or risk factors. (28,34,35) Only a few studies have been performed on unselected populations of women.…”

Section: Introductionmentioning

confidence: 99%

Abdominal Aortic Calcification, BMD, and Bone Microstructure: A Population-Based Study

Chow

Khosla

Melton

et al. 2008

Journal of Bone and Mineral Research

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ABSTRACT:To better define the relationship between vascular calcification and bone mass/structure, we assessed abdominal aortic calcification (AAC), BMD, and bone microstructure in an age-stratified, random sample of 693 Rochester, MN, residents. Participants underwent QCT of the spine and hip and high-resolution pQCT (HRpQCT) of the radius to define volumetric BMD (vBMD) and microstructural parameters. AAC was quantified with the Agatston scoring method. In men, AAC correlated with lower vertebral trabecular and femoral neck vBMD (p < 0.001), but not after age or multivariable (age, body mass index, smoking status) adjustment. Separation into <50 and Ն50 yr showed this pattern only in the older men. BV/TV and Tb.Th inversely correlated with AAC in all men (p < 0.001), and Tb.Th remained significantly correlated after age adjustment (p < 0.05). Tb.N positively correlated with AAC in younger men (p < 0.001) but negatively correlated in older men (p < 0.001). The opposite was true with Tb.Sp (p ‫ס‬ 0.01 and p < 0.001, respectively). Lower Tb.N and higher Tb.Sp correlated with AAC in older men even after multivariable adjustment. Among all women and postmenopausal women, AAC correlated with lower vertebral and femoral neck vBMD (p < 0.001) but not after adjustment. Lower BV/TV and Tb.Th correlated with AAC (p ‫ס‬ 0.03 and p ‫ס‬ 0.04, respectively) in women, but not after adjustment. Our findings support an age-dependent association between AAC and vBMD. We also found that AAC correlates with specific bone microstructural parameters in older men, suggesting a possible common pathogenesis for vascular calcification and deterioration in bone structure. However, sex-specific differences exist.

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French women, fractures and aortic calcifications

Cited by 22 publications

References 5 publications

Vascular calcification and fracture risk

Vascular calcification and fracture risk

Abdominal aortic calcification and risk of fracture among older women — The SOF study

Abdominal Aortic Calcification, BMD, and Bone Microstructure: A Population-Based Study

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