Frequency and risk factors for Chronic Thromboembolic Pulmonary Hypertension after a first unprovoked Pulmonary Embolism: results from PADIS-studies

Keep minds opening for chronic thromboembolic pulmonary hypertension: More data, less clarity

“…Considering near 4‐fold higher incidence in the unprovoked PE cohort, the incidence of 2.8% after unprovoked PE was consistent compared to the incidence of 0.56% after overall PE cohort pooled in meta‐analysis 4 . Notably, within PADIS‐PE, a programmed screening strategy was predesigned for all patients, consisting of transthoracic echocardiography; ventilation‐perfusion lung scanning at PE diagnosis, 6 months after PE, and 5 years after index PE; and whether patients were symptomatic or not 6 . This strategy helped screen out those CTEPH patients that presented with preserved cardiac function and exercise capacity, which enhanced the evidence of the results.…”

“…On this controversial academic topic, Fauché et al 6 recently reported their new findings that published in this issue of J Thromb Haemost . In this study, they assessed patients enrolled in the randomized, double‐blind, multicenter Prolonged Anticoagulation During 18 months versus Placebo after Initial Six‐month Treatment for a First Episode of Idiopathic Pulmonary Embolism (PADIS‐PE) trial 7 and applied programmed strategies to screen for CTEPH cases.…”

Chronic Thromboembolic Pulmonary Hypertension – Time is of the Essence

“…[ 2 ] There is a 2.8% cumulative incidence of CTEPH, 8 years after a first unprovoked PE. [ 3 ] However, the true prevalence of CTEPH is higher and includes patients with no known prior pulmonary emboli. Indeed, the association between CTEPH and prior DVT and PE is not always present, as demonstrated by an international prospective registry, where this association was present in only 56% of patients.…”