Frequency of adverse reactions to first- and second-line anti-tuberculosis chemotherapy in a Korean cohort

Mw, Carroll; M, Lee; Cai, Yong; Cw, Hallahan; Pa, Shaw; Min, JH; Lc, Goldfeder; Alekseyev,; Grinkrug, S; Hs, Kang; Hwang, Suntae; Hm, Park; Kang, Eunhwa; Lee, Soo-Youn; B, Jin; He, Pengkang; Shi, Min; Sk, Park; Ds, Jeon; Via, Laura E.; Barry, Clifton E.

doi:10.5588/ijtld.11.0574

Cited by 55 publications

(48 citation statements)

References 20 publications

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“…The incidence of acute bone marrow failure was estimated at less than 1 in 50,000 (45) and at 1 in 66,000 (44). In the setting of drug-resistant TB, the major toxicities of OPB should be considered in the context of the dire prognosis and compared with those of second-line drugs, which averaged 16% in a recent report (46). Of practical concern, most patients with TB who need second-line drugs fail to receive them because of cost.…”

Section: Discussionmentioning

confidence: 99%

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

Gold¹,

Pingle²,

Brickner³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

101

159

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Existing drugs are slow to eradicate Mycobacterium tuberculosis (Mtb) in patients and have failed to control tuberculosis globally. One reason may be that host conditions impair Mtb's replication, reducing its sensitivity to most antiinfectives. We devised a highthroughput screen for compounds that kill Mtb when its replication has been halted by reactive nitrogen intermediates (RNIs), acid, hypoxia, and a fatty acid carbon source. At concentrations routinely achieved in human blood, oxyphenbutazone (OPB), an inexpensive anti-inflammatory drug, was selectively mycobactericidal to nonreplicating (NR) Mtb. Its cidal activity depended on mild acid and was augmented by RNIs and fatty acid. Acid and RNIs fostered OPB's 4-hydroxylation. The resultant 4-butyl-4-hydroxy-1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione (4-OH-OPB) killed both replicating and NR Mtb, including Mtb resistant to standard drugs. 4-OH-OPB depleted flavins and formed covalent adducts with N-acetyl-cysteine and mycothiol. 4-OH-OPB killed Mtb synergistically with oxidants and several antituberculosis drugs. Thus, conditions that block Mtb's replication modify OPB and enhance its cidal action. Modified OPB kills both replicating and NR Mtb and sensitizes both to host-derived and medicinal antimycobacterial agents.

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Section: Discussionmentioning

confidence: 99%

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

Gold¹,

Pingle²,

Brickner³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

101

159

View full text Add to dashboard Cite

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“…Further, some anti-tuberculosis drugs used in second-line regimens for drug resistant tuberculosis also potentiate the toxicity of other agents used in the regimen. 18 Psychiatric adverse effects are known in the treatment of tuberculosis and are associated with increased mortality and unfavourable prognosis. 19 Majorities (92.07%) of the patients used vehicle to reach health centre, 59.4% of patients' time to reach the health center was less than 30 minutes and 64.3% patients waiting time was less than 15 minutes.…”

Section: Discussionmentioning

confidence: 99%

Side Effects Associated With Drugs Used in Treatment of Multi Drug Resistant Tuberculosis and Treatment Related Factors of Multi Drug Resistant Tuberculosis Patients in Kathmandu Valley

Bhatt

2017

SAARC J. Tuber. Lung Dis. HIV/AIDS

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Introduction: Treatment of multi drug resistant Mycobacterium tuberculosis (MDR-TB) with second line drugs is associated with adverse drug reactions and toxicity. Aim of this study were to determine side effects associated with drugs used in treatment of multi drug resistant tuberculosis and treatment related factors of MDR-TB patients.Methodology: A prospective study was carried out in National Tuberculosis Centre Bhaktapur Nepal. Questionnaires were used to collect data from patients.Results: Total 101 MDR TB patients were included among them majorities were male (52%) and mean age of the patients was 31.2 years. Majority of patients (87.1%) had previous history of tuberculosis treatment and 54.5% were in intensive phase of treatment. The side effect associated with drugs used in treatment of MDR-TB reported by patients were joint pain (21.2%), nausea (20.3%), hearing disturbances (11%), gastrointestinal disturbance (9.9%), depression (9.6%), itching (8.1%), hypothyroidism (6.4%), dizziness (6.4%), seizures (3.8%) and hepatitis (3.5%). Last month 25.74% patients missed one or more doses of drugs and 3.9% missed drug doses due to side effect of drugs. Majorities of the patients used vehicle to reach health centre (92.07%), time to reach the health center (59.4%) were less than 30 minutes but majorities of patients (57.4%) were not satisfied by the counseling of health care worker.Conclusion: The finding of this study shows that in MDR patients 12.8% were found new cases. Last month 3.9% patients were stopped the drugs due to side effects of drugs. Majority of patients (57.4%) were not satisfied by counseling of health care worker. Treatment of multi drug resistant tuberculosis with second line anti tubercular drugs is associated with side effects, health care worker counseling to MDR- TB patients with full attention is essential to encourage the patient’s moral and complete the treatment. Timely managing the side effects of medication is important in helping people to complete their treatment.SAARC J TUBER LUNG DIS HIV/AIDS, 2017; XIV(1), Page: 1-6

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“…(2014) bahwa efek samping yang paling banyak dialami penderita pada bulan pertama dan kedua adalah mual, pusing, gatal dan nyeri sendi. Penelitian ini didukung oleh Caroll et al (2012), bahwa efek samping utama yang paling sering timbul adalah gangguan pencernaan (mual, muntah, diare dan nyeri perut), gangguan nyeri sendi, gangguan psikis, gangguan visual dan gangguan syaraf. Hal ini juga dibuktikan oleh penelitian Sinha et al (2013) bahwa efek samping yang dialami antara lain gastronintestinal (53,52%), kelemahan umum (16,9%), disfungsi hati (15,49%), efek alergi pada kulit (8,45%), kelainan sistem saraf (2,82%), demam (2,82%).…”

Section: Pembahasanunclassified

Monitoring Of Side Effects Of Anti-Tuberculosis Drugs (ATD) On The Intensive Phase Treatment Of Pulmonary TB Patients In Makassar

Abbas¹

2017

AMS

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Frequency of adverse reactions to first- and second-line anti-tuberculosis chemotherapy in a Korean cohort

Abstract: MADRs are common during anti-tuberculosis chemotherapy in this population, occurring in more than one in six subjects. New and less toxic agents to treat drug-resistant TB are urgently needed.

Cited by 55 publications

References 20 publications

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

Side Effects Associated With Drugs Used in Treatment of Multi Drug Resistant Tuberculosis and Treatment Related Factors of Multi Drug Resistant Tuberculosis Patients in Kathmandu Valley

Monitoring Of Side Effects Of Anti-Tuberculosis Drugs (ATD) On The Intensive Phase Treatment Of Pulmonary TB Patients In Makassar

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