Frequency of respiratory viruses among patients admitted to 26 Intensive Care Units in seven consecutive winter-spring seasons (2009–2016) in Northern Italy

Piralla, Antonio; Mariani, B; Rovida, Francesca; Baldanti, Fausto

doi:10.1016/j.jcv.2017.05.004

Cited by 35 publications

(41 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Piralla et al reviewed the microbiological data of severe CAP in Northern Italy during winter-spring seasons over 7 years and found that 54.6% of patients had one or more respiratory viruses identified [23]. The 2 most common viruses isolated were Influenza A and Rhinovirus, similar with our findings.…”

Section: Discussionsupporting

confidence: 88%

Impact of microbial Aetiology on mortality in severe community-acquired pneumonia

et al. 2018

View full text Add to dashboard Cite

BackgroundThe impact of different classes of microbial pathogens on mortality in severe community-acquired pneumonia is not well elucidated. Previous studies have shown significant variation in the incidence of viral, bacterial and mixed infections, with conflicting risk associations for mortality. We aimed to determine the risk association of microbial aetiologies with hospital mortality in severe CAP, utilising a diagnostic strategy incorporating molecular testing. Our primary hypothesis was that respiratory viruses were important causative pathogens in severe CAP and was associated with increased mortality when present with bacterial pathogens in mixed viral-bacterial co-infections.MethodsA retrospective cohort study from January 2014 to July 2015 was conducted in a tertiary hospital medical intensive care unit in eastern Singapore, which has a tropical climate. All patients diagnosed with severe community-acquired pneumonia were included.ResultsA total of 117 patients were in the study. Microbial pathogens were identified in 84 (71.8%) patients. Mixed viral-bacterial co-infections occurred in 18 (15.4%) of patients. Isolated viral infections were present in 32 patients (27.4%); isolated bacterial infections were detected in 34 patients (29.1%). Hospital mortality occurred in 16 (13.7%) patients. The most common bacteria isolated was Streptococcus pneumoniae and the most common virus isolated was Influenza A. Univariate and multivariate logistic regression showed that serum procalcitonin, APACHE II severity score and mixed viral-bacterial infection were associated with increased risk of hospital mortality. Mixed viral-bacterial co-infections were associated with an adjusted odds ratio of 13.99 (95% CI 1.30–151.05, p = 0.03) for hospital mortality.ConclusionsRespiratory viruses are common organisms isolated in severe community-acquired pneumonia. Mixed viral-bacterial infections may be associated with an increased risk of mortality.

show abstract

Section: Discussionsupporting

confidence: 88%

Impact of microbial Aetiology on mortality in severe community-acquired pneumonia

et al. 2018

View full text Add to dashboard Cite

show abstract

“…R espiratory tract infections include both upper tract infections, such as the common cold, and lower tract infections, such as pneumonia, bronchitis, bronchiolitis, and exacerbation of asthma. Lower respiratory tract infections cause substantial morbidity and mortality and are a leading cause of hospitalization, especially for infants, the elderly, and immunocompromised individuals (1)(2)(3)(4). Respiratory tract infections are caused by a wide variety of pathogens, which include several viral and bacterial agents.…”

mentioning

confidence: 99%

Impact of Rapid Molecular Detection of Respiratory Viruses on Clinical Outcomes and Patient Management

Kuypers

2019

J Clin Microbiol

View full text Add to dashboard Cite

To determine if rapid molecular testing for respiratory viruses in patients with respiratory illnesses can provide advantages to patients and hospitals, rigorous investigations on the impacts of using these assays are required. Well-conducted studies are needed to inform decisions about implementation of new rapid assays to replace standard molecular testing or to initiate testing in laboratories that are currently not doing molecular tests for respiratory viruses due to the complex nature of standard panels. In this issue of the Journal of Clinical Microbiology, N. Wabe et al. (J Clin Microbiol 57:e01727-18, 2019, https://doi.org/10.1128/JCM.01727-18) report the results of their evaluation of the impact of using a rapid molecular test for influenza A/influenza B and RSV on outcomes for adults hospitalized with respiratory illness. The median time from admission to test result of the rapid test was 7.5 h compared to 40.3 h for the standard PCR assay. Compared to the use of the standard molecular assay, use of a rapid test significantly shortened time in the hospital and reduced the number of other microbiology tests performed. The authors concluded that rapid PCR testing of adults hospitalized with respiratory illnesses could provide benefits to both the patients and the hospital. Patients were able to leave the hospital earlier and a greater proportion of them had received their test results before discharge, which would allow appropriate treatment to be provided more quickly.

show abstract

“…Indeed, the role of rhinovirus in lower respiratory tract infections is increasingly established, 20 and it is one of the most frequent viruses causing severe infections, second to RSV in children, [17][18][19] and after influenza in adults. 15,[21][22][23] Its presentation year-round, with peaks in autumn and winter, 24 also contributes to its high overall impact.…”

Section: Discussionmentioning

confidence: 99%

“…year, and our model associated this to RSV, consistent with its earlier presentation in the season. 13,16,25 RSV is the leading cause of SARI in young children 13,[17][18][19]23 and has been highly associated to SARI syndromes in emergency departments 6,14 and ambulances. 10,18 The differences between office and out-of-office hours likely reflect that ambulance calls in these two time frames are distinct populations, probably with a different share of clinical pictures and severity.…”

Section: Discussionmentioning

confidence: 99%

Ambulance dispatch calls attributable to influenza A and other common respiratory viruses in the Netherlands (2014‐2016)

Monge

Duijster

Kommer

et al. 2020

Influenza Resp Viruses

View full text Add to dashboard Cite

Background: Ambulance dispatches could be useful for syndromic surveillance of severe respiratory infections. We evaluated whether ambulance dispatch calls of highest urgency reflect the circulation of influenza A virus, influenza B virus, respiratory syncytial virus (RSV), rhinovirus, adenovirus, coronavirus, parainfluenzavirus and human metapneumovirus (hMPV). Methods:We analysed calls from four ambulance call centres serving 25% of the population in the Netherlands (2014)(2015)(2016). The chief symptom and urgency level is recorded during triage; we restricted our analysis to calls with the highest urgency and identified those compatible with a respiratory syndrome. We modelled the relation between respiratory syndrome calls (RSC) and respiratory virus trends using binomial regression with identity link function. Results:We included 211 739 calls, of which 15 385 (7.3%) were RSC. Proportion of RSC showed periodicity with winter peaks and smaller interseasonal increases.Overall, 15% of RSC were attributable to respiratory viruses (20% in out-of-office hour calls). There was large variation by age group: in <15 years, only RSV was associated and explained 11% of RSC; in 15-64 years, only influenza A (explained 3% of RSC); and in ≥65 years adenovirus explained 9% of RSC, distributed throughout the

show abstract

Frequency of respiratory viruses among patients admitted to 26 Intensive Care Units in seven consecutive winter-spring seasons (2009–2016) in Northern Italy

Cited by 35 publications

References 22 publications

Impact of microbial Aetiology on mortality in severe community-acquired pneumonia

Impact of microbial Aetiology on mortality in severe community-acquired pneumonia

Impact of Rapid Molecular Detection of Respiratory Viruses on Clinical Outcomes and Patient Management

Ambulance dispatch calls attributable to influenza A and other common respiratory viruses in the Netherlands (2014‐2016)

Contact Info

Product

Resources

About