Fresh Mango Consumption Promotes Greater Satiety and Improves Postprandial Glucose and Insulin Responses in Healthy Overweight and Obese Adults

Pinneo, Sherry; O'Mealy, Celéste; Rosas, Martin; Tsang, Michelle; Liu, Changqi; Kern, Mark; Hooshmand, Shirin; Hong, Mee Young

doi:10.1089/jmf.2021.0063

Cited by 9 publications

(7 citation statements)

References 43 publications

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“…Table 2 summarizes the main findings of the included studies. Pinneo et al [8] focused their research on analyzing the effect of mango consumption on biochemical parameters and satiety responses. However, the study has a limitation because it measures satiety hormones at only 45 min after consumption, as each hormone may have a different time curve.…”

Section: Indica and Health Effects: Results From Clinical Trialsmentioning

confidence: 99%

“…Mangoes contain ascorbic acid, gallic acid, protocatechuic acid, chlorogenic acid, and vanillic acid as the major phenolics. Mango pulp contains sugars; vitamins (such as ascorbic acid and carotenoids); polyphenols such as xanthonoids (mangiferin); flavonoids such as catechins, kaempferol, rhamnetin, quercetin, and anthocyanins; tannins such as gallotannins; and phenolic acids and derivatives thereof, such as ellagic acid, gallic acid, protocatechuic acid, methyl gallate, and propyl gallate [8].…”

Section: Introductionmentioning

confidence: 99%

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Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

Minniti,

Laurindo,

Machado

et al. 2023

Life

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Mango and its by-products have traditional medicinal uses. They contain diverse bioactive compounds offering numerous health benefits, including cardioprotective and metabolic properties. This study aimed to explore the impact of mango fruit and its by-products on human health, emphasizing its metabolic syndrome components. PUBMED, EMBASE, COCHRANE, and GOOGLE SCHOLAR were searched following PRISMA guidelines, and the COCHRANE handbook was utilized to assess bias risks. In vivo and in vitro studies have shown several benefits of mango and its by-products. For this systematic review, 13 studies met the inclusion criteria. The collective findings indicated that the utilization of mango in various forms—ranging from fresh mango slices and mango puree to mango by-products, mango leaf extract, fruit powder, and mangiferin—yielded many favorable effects. These encompassed enhancements in glycemic control and improvements in plasma lipid profiles. Additionally, mango reduces food intake, elevates mood scores, augments physical performance during exercise, improves endothelial function, and decreases the incidence of respiratory tract infections. Utilizing mango by-products supports the demand for healthier products. This approach also aids in environmental conservation. Furthermore, the development of mango-derived nanomedicines aligns with sustainable goals and offers innovative solutions for healthcare challenges whilst being environmentally conscious.

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Section: Indica and Health Effects: Results From Clinical Trialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

Minniti,

Laurindo,

Machado

et al. 2023

Life

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“…Mangos are rich in vitamins C and A, magnesium, potassium, bioactive phytochemicals (e.g., mangiferin, flavonoids, phenolic acids, and carotenoids), and fiber (Maldonado‐Celis et al, 2019 ; Ribeiro & Schieber, 2010 ). Mangos have been observed to promote many health benefits linked to inflammation and obesity, such as the reduction in pro‐inflammatory cytokines and C‐reactive protein (Fang et al, 2018 ; Rosas et al, 2022 ) and suppressing appetite while increasing satiety (Pinneo et al, 2022 ). The rich fiber content of mango may also exert a positive influence on the microbiome.…”

Section: Introductionmentioning

confidence: 99%

The effects of fresh mango consumption on gut health and microbiome – Randomized controlled trial

Asuncion

Liu

Castro

et al. 2023

Food Science & Nutrition

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Some individual fruits have been widely researched for their effects on overall health and correlations with chronic diseases. The beneficial effects of mango supplementation on metabolic diseases have been detected. However, research into mango consumption on gut health, including the microbiome, is limited to processed mango preparations or peels. Our goal was to examine the effects of fresh mango consumption on the gut microbiome, gut permeability proteins, and bowel movement habits in overweight/obese individuals. In a 12‐week crossover design study, 27 participants consumed 100 kcal/day of either mangos or low‐fat cookies with a washout period of 4 weeks. The mango intervention showed higher Shannon–Wiener and Simpson alpha diversity indices of the microbiome than the low‐fat cookie intervention in week 4. Significant differences in beta diversity of the microbiome were found between diet interventions at week 12. Mango consumption increased the abundance of Prevotella maculosa, Corynebacterium pyruviciproducens, and Mogibacterium timidum while it decreased Prevotella copri. Low‐fat cookie intake increased Cyanobacterium aponinum and Desulfovibrio butyratiphilus and reduced Alloscardovia omnicolens. There were no significant differences in circulating gut permeability protein (ZO‐1, claudin‐2, and occludin) levels. There was a slight increase in the amount of bowel movement with mango consumption, but no significant findings for frequency, consistency, strain, pain, and constipation in bowel movement between trials. Given these results, it can be concluded that consumption of mango may have positive effects on the gut health, which may yield possible health benefits for chronic disease that deserve further study.

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“…In addition, mango juice intake decreases adiposity and inflammation in high-fat-diet-fed obese rats [ 38 ], while mango fruit powder reduces insulin resistance and steatosis [ 39 ]. Furthermore, it has been shown that fresh mango consumption improves postprandial glucose and insulin responses in obese adults [ 40 ]. Arshad et al demonstrated that the consumption of mango peel powder reduced oxidative stress and dyslipidemia in obese subjects [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Hypertrophy and ER Stress Induced by Palmitate Are Counteracted by Mango Peel and Seed Extracts in 3T3-L1 Adipocytes

Pratelli

Liberto

Carlisi

et al. 2023

IJMS

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A diet rich in saturated fatty acids (FAs) has been correlated with metabolic dysfunction and ROS increase in the adipose tissue of obese subjects. Thus, reducing hypertrophy and oxidative stress in adipose tissue can represent a strategy to counteract obesity and obesity-related diseases. In this context, the present study showed how the peel and seed extracts of mango (Mangifera indica L.) reduced lipotoxicity induced by high doses of sodium palmitate (PA) in differentiated 3T3-L1 adipocytes. Mango peel (MPE) and mango seed (MSE) extracts significantly lowered PA-induced fat accumulation by reducing lipid droplet (LDs) and triacylglycerol (TAGs) content in adipocytes. We showed that MPE and MSE activated hormone-sensitive lipase, the key enzyme of TAG degradation. In addition, mango extracts down-regulated the adipogenic transcription factor PPARγ as well as activated AMPK with the consequent inhibition of acetyl-CoA-carboxylase (ACC). Notably, PA increased endoplasmic reticulum (ER) stress markers GRP78, PERK and CHOP, as well as enhanced the reactive oxygen species (ROS) content in adipocytes. These effects were accompanied by a reduction in cell viability and the induction of apoptosis. Interestingly, MPE and MSE counteracted PA-induced lipotoxicity by reducing ER stress markers and ROS production. In addition, MPE and MSE increased the level of the anti-oxidant transcription factor Nrf2 and its targets MnSOD and HO-1. Collectively, these results suggest that the intake of mango extract-enriched foods in association with a correct lifestyle could exert beneficial effects to counteract obesity.

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Fresh Mango Consumption Promotes Greater Satiety and Improves Postprandial Glucose and Insulin Responses in Healthy Overweight and Obese Adults

Cited by 9 publications

References 43 publications

Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

The effects of fresh mango consumption on gut health and microbiome – Randomized controlled trial

Hypertrophy and ER Stress Induced by Palmitate Are Counteracted by Mango Peel and Seed Extracts in 3T3-L1 Adipocytes

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