From discovery to development: Current industry perspectives for the development of novel methods of helminth control in livestock

Waller, P.J.

doi:10.1016/j.vetpar.2006.02.036

Cited by 183 publications

(131 citation statements)

References 11 publications

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“…Bien qu'il est souvent difficile de chiffrer l'impact économique de ces pathologies, il est certain qu'elles occasionnent de lourdes pertes tant directes (baisses de productions et mortalité) qu'indirectes (coût de la lutte). Quant à l'efficience des moyens de lutte, des chercheurs soutiennent, de par le monde, que l'usage abusif des anthelminthiques de synthèse serait une cause majeure du phénomène de résistances développées par les strongles (Jackson et Coop, 2000 ;BengoneNdong et Alvinerie, 2004 ;Kaplan, 2004 ;Coles et al, 2006 ;Pomroy, 2006 ;Waller, 2006 (Ahmed et al, 2012). Communément appelé arbre à papier de verre, F. exasperata est une plante à fleurs atteignant 20 m de hauteur et dont les feuilles ovales ont une face rugueuse.…”

Section: Introductionunclassified

Effets strongylicides in vitro de l’extrait aqueux de feuilles de Ficus exasperata Valh. 1805 (Moraceae)

Houngnimassou¹,

Attindehou²,

Salifou³

et al. 2017

Int. J. Bio. Chem. Sci

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REMERCIEMENTS Les auteurs remercient le Ministère de l'Enseignement Supérieur et de la Recherche Scientifique du Benin pour son appui financier sous forme de bourses doctorales.RESUME L'usage massif et abusif de composés chimiques dans la lutte contre les parasitoses animales a montré ses limites tant sur le plan efficacité (échecs consécutifs au phénomène de résistances) que sur le plan écologique (écotoxicité des molécules). Les recettes ethno-vétérinaires, qui se fondent sur l'exploitation de la riche flore tropicale, constituent une intéressante piste de recherche de solutions alternatives et durables. La présente étude a eu pour objectif d'évaluer in vitro les effets strongylicides de l'extrait aqueux de feuilles de Ficus exasperata (plante tropicale de la famille des Moraceae) sur des adultes de Haemonchus contortus (parasite gastro-intestinal des ruminants). L'étude a consisté en un test de mortalité par contact. Les vers ont été récoltés dans la caillette de moutons naturellement infestés puis exposés à six (6) concentrations différentes (4, 8, 16, 32, 64 In vitro strongylicide effects of the aqueous extract of leaves ofFicus exasperata Valh. 1805 (Moraceae) ABSTRACTThe massive and excessive use of chemical compounds in the management of animal parasites showed its limits both for efficiency (therapeutic failures due to resistances phenomenon) as for ecological aspect (ecotoxicity of molecules). The ethno-veterinary recipes which base on the exploitation of the rich tropical H. M. A. HOUNGNIMASSOUN et al. / Int. J. Biol. Chem. Sci. 11(3): 1012-1020, 2017 1013 flora represent a precious way of alternative and sustainable solutions. This study aimed at estimating, in vitro, the strongylicide effects of the aqueous extract of leaves of Ficus exasperata (a tropical plant of Moracea's family) against adults of Haemonchus contortus (a gastroenteritis parasite). Worms adult motility test was undertaken. Worms collected from the abomasum of naturally infested sheep were exposed to six (6) concentrations (4, 8, 16, 32, 64 and 128 mg/ml) of the plant extract. Levamisole has been the reference drug. A solution of Phosphate Buffer Saline (PBS) was the negative control. The test was repeated six times. The results indicated significant (p˂0.001) mortalities from 66.66 to 83.33%. Thus, the study highlighted the extract's dose depending strongylicide effect with average and total lethal doses (LC 50 and LC 99 ) respectively of 7.8 mg/ml and 19.1 mg/ml. The leaves of Ficus exasperata possess some anthelminthic properties requiring thorough studies.

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Section: Introductionunclassified

Effets strongylicides in vitro de l’extrait aqueux de feuilles de Ficus exasperata Valh. 1805 (Moraceae)

Houngnimassou¹,

Attindehou²,

Salifou³

et al. 2017

Int. J. Bio. Chem. Sci

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“…However, the efficacy of anthelmintics is increasingly endangered by development of resistance in nematode populations (MILLER et al, 2012). Control by anthelmintics has presented problems, such as the development of resistance in nematodes, the poor availability and high cost of commercial products, especially to low income farmers in developing countries, and increasing concern over the risk of environmental contamination because the presence of drug residues in animal products when pure compounds are administered (WALLER, 2006). These concerns have led to the search for and evaluation of alternative control methods (ATHANASIADOU et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

Macedo

Oliveira

Camurça-Vasconcelos

et al. 2013

Rev. Bras. Parasitol. Vet.

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In vitro effects of AbstractPhytotherapy can be an alternative for the control of gastrointestinal parasites of small ruminants. This study evaluated the efficacy of Alpinia zerumbet, Coriandrum sativum, Tagetes minuta and Lantana camara essential oils by two in vitro assays on Haemonchus contortus, an egg hatch test (EHT) and larval development test (LDT). No effect was observed for L. camara in the EHT. A. zerumbet, C. sativum and T. minuta essential oils exhibited a dose-dependent effect in the EHT, inhibiting 81.2, 99 and 98.1% of H. contortus larvae hatching, respectively, at a concentration of 2.5 mg mL -1 . The effective concentration to inhibit 50% (EC50) of egg hatching was 0.94, 0.63 and 0.53 mg mL -1 for A. zerumbet, C. sativum and T. minuta essential oils, respectively. In LDT, L. camara, A. zerumbet, C. sativum and T. minuta at concentration of 10 mg mL -1 inhibited 54.9, 94.2, 97.8 and 99.5% of H. contortus larval development, presenting EC50 values of 6.32, 3.88, 2.89 and 1.67 mg mL -1 , respectively. Based on the promising results presented in this in vitro model, it may be possible use of these essential oils to control gastrointestinal nematodes. However, their anthelmintic activity should be confirmed in vivo.Keywords: Phytotherapy, anthelmintic, gastrointestinal nematodes. ResumoFitoterapia pode ser uma alternativa para o controle de parasitas gastrintestinais de pequenos ruminantes. Este estudo avaliou a eficácia dos óleos essenciais de Alpinia zerumbet, Coriandrum sativum, Tagetes minuta e Lantana camara sobre Haemonchus contortus através de dois testes in vitro, teste de eclosão dos ovos (TEO) e teste de desenvolvimento larval (TDL). Nenhum efeito foi observado para L. camara no TEO. Os óleos essenciais de A. zerumbet, C. sativum e T. minuta exibiram um efeito dose dependente no TEO inibindo a eclosão das larvas de H. contortus em 81,2, 99 e 98,1%, respectivamente, na concentração de 2,5 mg mL -1 . A concentração efetiva para inibir 50% (CE50) da eclosão dos ovos foi de 0,94, 0,63 e 0,53 mg mL -1 para os óleos essenciais de A. zerumbet, C. sativum e T. minuta, respectivamente. No TDL, 10 mg mL -1 de L. camara, A. zerumbet, C. sativum e T. minuta inibiram em 54,9, 94,2, 97,8 e 99,5% do desenvolvimento larvar, apresentando valores de CE50 de 6,32, 3,88, 2,89 e 1,67 mg mL -1 , respectivamente. Com base nos resultados promissores apresentados neste modelo in vitro, pode ser possível a utilização destes óleos essenciais para controlar os nematoides gastrintestinais. No entanto, a sua atividade anti-helmíntica deve ser confirmada in vivo.Palavras-chave: Fitoterapia, anti-helmínticos, nematoides gastrintestinais.

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“…The emergence of nematode populations with resistance to anthelmintics and the concern about chemical residues in animal products threaten the sustainability of this approach (Waller, 2006). Alternative strategies for the control of gastrointestinal nematode infections, include selection of genetically resistant breeds and the development of effective vaccine (Gray, 1997;Newton and Munn, www.elsevier.com/locate/vetpar Available online at www.sciencedirect.com Veterinary Parasitology 158 (2008) [311][312][313][314][315][316][317][318] 1999).…”

Section: Introductionmentioning

confidence: 99%

Serum antibody responses in Creole kids experimentally infected with Haemonchus contortus

Bambou¹,

Chevrotière²,

Varo³

et al. 2008

Veterinary Parasitology

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The objective of this study was to evaluate the relationship of parasite-specific serum antibodies with the resistance status of Creole kids. The average breeding values on egg output predicted in a context of natural infection at 11 months of age were distant of 1.07 genetic standard deviation between resistant and susceptible animals. After drenching the animals were maintained worm-free during 1 month until experimental infection with 10,000 Haemonchus contortus infective larvae (L3). Enzyme-linked immunosorbent assay was carried out in serum samples to determine the level of IgG, IgA and IgE anti-H. contortus L3 crude extracts and adult excretion/secretion products (ESP). Parasitological and blood immunological parameters were measured on the 2 extreme groups. Despite the absence of any typical signs of haemonchosis, susceptible kids had more than 11 times higher faecal egg counts (FEC) at 35 days post-infection (d.p.i.) than resistant kids had. Levels of immunoglobulin against H. contortus L3 and ESP increased significantly after infection in both groups. However, no difference in the host immune response mediated by immunoglobulin against H. contortus was evidenced between groups. This finding suggests that, in goats previously infected by H. contortus, a degree of protection occurred and the phenotypic and genetic segregation in resistant and susceptible animals were not related to the humoral immune response. The correlation coefficients between FEC and IgE anti-ESP (r = 0.593; P < 0.05 was significant in both resistant and susceptible animals. Such correlation suggesting a hypersensitivity reaction dependent on worm prolificacy has never been described. This result needs further studies to understand the mechanisms underlying this observation. #

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From discovery to development: Current industry perspectives for the development of novel methods of helminth control in livestock

Cited by 183 publications

References 11 publications

Effets strongylicides <i>in vitro</i> de l’extrait aqueux de feuilles de <i>Ficus exasperata</i> Valh. 1805 (Moraceae)

Effets strongylicides <i>in vitro</i> de l’extrait aqueux de feuilles de <i>Ficus exasperata</i> Valh. 1805 (Moraceae)

In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

Serum antibody responses in Creole kids experimentally infected with Haemonchus contortus

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