Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Vrieling, Alina; Verhage, Bas A.J.; Duijnhoven, Fränzel J.B. van; Jenab, Mazda; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Clavel‐Chapelon, Françoise; Boutron-Ruault, Marie Christine; Kaaks, Rudolf; Rohrmann, Sabine; Boeing, Heiner; Nöthlings, Ute; Trichopoulou, Antonia; Ma, John T C; Zilis, D.; Palli, Domenico; Sieri, Sabina; Mattiello, Amalia; Tumino, Rosario; Víneis, Paolo; Gils, Carla H. van; Peeters, Petra H.; Engeset, Dagrun; Lund, Eiliv; Suárez, Laudina Rodríguez; Jakszyn, Paula; Larrañaga, Nerea; Sánchez, María José; Chirlaque, María Dolores; Ardanaz, Eva; Manjer, Jonas; Lindkvist, Björn; Hallmans, Göran; Ye, Weimin; Bingham, Sheila; Khaw, Kay Tee; Roddam, Andrew; Key, Tim; Boffetta, Paolo; Duell, Eric J.; Michaud, Dominique S.; Riboli, Elio; Bueno-de-Mesquita, H. Bas

doi:10.1002/ijc.24134

Cited by 69 publications

(56 citation statements)

References 29 publications

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“…The relation between fruit and vegetable intake and pancreatic cancer risk has been examined in 20 case-control studies (10, 12, 14-21, 52-61) and 16 cohort studies (8,9,11,13,22,(62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72), 4 of which were included in our pooled analysis (8,13,22; 2 studies were included in reference 8).…”

Section: Discussionmentioning

confidence: 99%

“…The findings from prospective studies have been weaker. Of the 8 studies not included in our pooled analysis that evaluated total fruit intake (11,62,64,65,68,(70)(71)(72), associations were null in 3 (11,62,64), while risk reductions for the highest versus lowest intakes ranged from 11% to 49% in the others; findings were statistically significant in only 1 study (69). Similarly, associations with vegetable intake were null in 3 (11,64,66) of the 8 prospective studies that evaluated total vegetable intake, while risk reductions ranged from 14% to 36% in the other studies (9,65,68,69,72), only 1 of which had statistically significant findings (72).…”

Section: Discussionmentioning

confidence: 99%

“…The risk of pancreatic cancer in relation to fruit and vegetable consumption has been examined in over 35 epidemiologic studies (4,(7)(8)(9)(10)(11)(12)(13), and most have found inverse associations with fruit and/or vegetable intake. However, associations have been stronger in case-control studies than in cohort studies, and most case-control studies have relied on proxy respondents for exposure information, with proportions of proxies exceeding 50% of the case series in many studies (14)(15)(16)(17)(18)(19)(20)(21).…”

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confidence: 99%

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Intake of Fruits and Vegetables and Risk of Pancreatic Cancer in a Pooled Analysis of 14 Cohort Studies

Koushik¹,

Spiegelman²,

Albanês³

et al. 2012

American Journal of Epidemiology

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Fruit and vegetable intake may protect against pancreatic cancer, since fruits and vegetables are rich in potentially cancer-preventive nutrients. Most case-control studies have found inverse associations between fruit and vegetable intake and pancreatic cancer risk, although bias due to reporting error cannot be ruled out. In most prospective studies, inverse associations have been weaker and imprecise because of small numbers of cases. The authors examined fruit and vegetable intake in relation to pancreatic cancer risk in a pooled analysis of 14 prospective studies from North America, Europe, and Australia (study periods between 1980 and 2005). Relative risks and 2-sided 95% confidence intervals were estimated separately for the 14 studies using the Cox proportional hazards model and were then pooled using a random-effects model. Of 862,584 men and women followed for 7−20 years, 2,212 developed pancreatic cancer. The pooled multivariate relative risks of pancreatic cancer per 100-g/day increase in intake were 1.01 (95% confidence interval (CI): 0.99, 1.03) for total fruits and vegetables, 1.01 (95% CI: 0.99, 1.03) for total fruits, and 1.02 (95% CI: 0.99, 1.06) for total vegetables. Associations were similar for men and women separately and across studies. These results suggest that fruit and vegetable intake during adulthood is not associated with a reduced pancreatic cancer risk. diet; fruit; pancreatic neoplasms; prospective studies; vegetables Abbreviations: CI, confidence interval; FFQ, food frequency questionnaire.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Intake of Fruits and Vegetables and Risk of Pancreatic Cancer in a Pooled Analysis of 14 Cohort Studies

Koushik¹,

Spiegelman²,

Albanês³

et al. 2012

American Journal of Epidemiology

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“…15, 33-35, 61; four showing an association more strongly, or only, with estrogenreceptor-negative cancers with the exposure variable ranging across vegetables, vegetables and fruit, some specified fruits, and serum carotenoids). In contrast, cohort studies were null for the following cancers: two of two on pancreas (62,63); two of two on esophageal adenocarcinoma (44,45) Given the definable heterogeneity reported here, studies of total cancer are problematic but at least two such studies reported a reduced risk, one showing reduced incidence with higher intake of a Mediterranean diet (68) and the other reduced cancer mortality with higher consumption of total vegetables and fruit (69).…”

Section: Plant Foods and Cancermentioning

confidence: 78%

Nutritional Epidemiology—There's Life in the Old Dog Yet!

Potter

2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Consideration is given to the idea that the nutritional epidemiology of cancer is dead, as some in the media have claimed. The basis for the claim does not lie in science nor has anyone with relevant knowledge made such a statement-although that, too, has been claimed. Evidence is adduced for the importance of past achievements of nutritional epidemiology. Attention is similarly drawn to recent contributions. In particular, I note the state of play of cancer and plant foods, fat and breast cancer, meat and cancer, vegetarians, intervention studies, migrant studies, and westernization of diet and lifestyle. Some next steps and some currently important questions are outlined. Cancer Epidemiol Biomarkers Prev; 24(2); 323-30. Ó2014 AACR.

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“…No strong link has been found between diet and pancreatic cancer [28]. However, study done by Ghorbani Z et al [29] have shown in a well-matched case control study that increased frequency of intake of rice, bread and barbequed meat and deep fried vegetables can aggregate the risk while consumption of fish can decrease the incidence of pancreatic cancer.…”

Section: Dietmentioning

confidence: 99%

Epidemiology of Pancreatic and Periampullary Cancer

Thapa

2015

Indian J Surg

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Pancreatic cancer is an important public health problem, although infrequent but with an exceptionally high mortality rate worldwide. Given that the majority of cancers occur in association with smoking, diabetes, pancreatitis, genetic factors, and others and with a growing population worldwide in mind, more cases would be expected in the near future giving further impetus to investigating prevention and treatment strategies to this international issue. The representative data on epidemiology of carcinoma of pancreas in India and Nepal are very poor. While there are many questions to be resolved, it is apparent that many facets of pancreatic cancer are becoming increasingly understood, and prospects for prevention are becoming apparent. Hence, screening research, recommendations, and implementation is an obvious priority. Although previous studies have contributed to the knowledge of carcinoma of pancreas epidemiology, such association needs to be further verified with proper epidemiological work. A new and global approach to the study of carcinoma of pancreas epidemiology is required if the disease prevention and treatment strategies are to be adequately directed and supported in the coming years. The collection and analysis of epidemiologic carcinoma of pancreas data will play a critical role in guiding future disease prevention strategies and optimizing patient management.

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Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Abstract: Abbreviations: 24HR, 24-hour diet recalls; 95% CI, 95% confidence interval; BMI, body mass index; EPIC, European Prospective Investigation into Cancer and Nutrition; FFQ, food frequency questionnaire; HR, hazard ratio; ICD-O, International

Cited by 69 publications

References 29 publications

Intake of Fruits and Vegetables and Risk of Pancreatic Cancer in a Pooled Analysis of 14 Cohort Studies

Intake of Fruits and Vegetables and Risk of Pancreatic Cancer in a Pooled Analysis of 14 Cohort Studies

Nutritional Epidemiology—There's Life in the Old Dog Yet!

Epidemiology of Pancreatic and Periampullary Cancer

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