Fucoxanthin, Tetraprenylated Toluquinone and Toluhydroquinone Metabolites from Sargassum heterophyllum Inhibit the in vitro Growth of the Malaria Parasite Plasmodium falciparum

Afolayan, Anthonia F.; Bolton, John J.; Lategan, Carmen; Smith, Peter J.; Beukes, Denzil R.

doi:10.1515/znc-2008-11-1211

Cited by 57 publications

(44 citation statements)

References 17 publications

(20 reference statements)

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“…Among the Phaeophyceae, the genus Sargassum is well known to produce compounds with antioxidant, antibacterial, antitumoral, antimalarial, antiherbivory and antifouling (AF) properties (Amsler and Fairhead 2006;Rastian et al 2007;Afolayan et al 2008;Heo and Jeon 2009;Plouguerné et al 2010). Rather than screening among a wide variety of different species of macroalgae for AF activity (e.g.…”

Section: Introductionmentioning

confidence: 99%

Antifouling activity as a function of population variation in Sargassum vulgare from the littoral of Rio de Janeiro (Brazil)

et al. 2010

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The brown seaweed Sargassum vulgare is abundant along the coast of Rio de Janeiro state. An investigation of the spatial variation of antifouling activity was conducted, in which algae were collected at five locations along the coast of Rio de Janeiro during October 2008. Hexane, dichloromethane, methanol and acetone/water extracts were prepared and screened for their bioactivities against the growth of five strains of marine fouling bacteria, five biofilm-associated microphytobenthic strains and attachment of the mussel Perna perna. The most active were the hexane extracts from Bananal algae that inhibited the growth of all microalgae tested; the methanol and dichloromethane extracts from Mar do Norte, which inhibited Vibrio aestuarianus and Pseudoalteromonas elyakovii and the polyphenol extracts from Ilha de Itacuruçá and Bananal that inhibited mussel attachment, respectively, by 64% and 71% compared to controls.

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Section: Introductionmentioning

confidence: 99%

Antifouling activity as a function of population variation in Sargassum vulgare from the littoral of Rio de Janeiro (Brazil)

et al. 2010

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“…Ikatan alenik pada f ukosantin bertanggung jawab terhadap aktivitas antioksidannya (Sachindra et al, 2007) sedangkan efek antiproliferasi fukosantin kemungkinan besar disebabkan oleh adanya struktur 5,6-epoksi pada fukosantin (Asai, Sugawara, Ono & Nagao, 2004). Afolayan, Bolton, Lategan, Smith & Beukes (2008) juga menduga ada hubungan antara ikatan alenik dengan sif at antiplasmodial pada fukosantin. Hasil analisis secara in silico memperlihatkan bahwa gugus karboksil pada fukosantin membentuk ikatan hidrogen dengan tubulin pada sel yang berakibat pada depolimerasasi mikrotubulin dan penghambatan siklus sel (Januar, Dewi,Marraskuranto & Wikanta, 2012 …”

Section: Uji Sitotoksisitasunclassified

Isolasi Fukosantin dari Rumput Laut Coklat Padina australis dan Sitotoksisitasnya terhadap Sel MCF7 dan Sel Vero

Nursid

Noviendri

Rahayu

et al. 2017

JPBKP

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ABSTRAKFukosantin merupakan karotenoid laut yang banyak terdapat pada rumput laut coklat. Fukosantin memiliki potensi yang menjanjikan untuk diaplikasikan pada bidang kesehatan. Padina australis merupakan salah satu rumput laut coklat yang banyak mengandung fukosantin. Penelitian ini bertujuan untuk mengisolasi fukosantin dari rumput laut P. australis dan mengetahui sitotoksisitasnya terhadap sel lestari kanker MCF7 dan sel normal Vero. Isolasi fukosantin dilakukan dengan menggunakan kromatografi kolom SiO 2 . Identifikasi fukosantin dilakukan dengan menggunakan liquid chromatography ion trap time of flight mass spectrofotometer (LC-IT-ToF-MS) berdasarkan profil serapan UV dan berat molekul. Uj i sitotoksik dilakukan dengan menggunakan uji (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (uji MTT). Fukosantin berhasil diisolasi dari ekstrak kasar metanol. Fukosantin terkonfirmasi pada panjang gelombang maksimum (maks) 447 nm pada spektrum UV. Puncak monoisotopik ion molekul fukosantin terdeteksi pada nilai m/z 659,3612 [M+H]. Hasil uji MTT memperlihatkan bahwa fukosantin dari P. australis memiliki sitotoksisitas terhadap sel MCF7 dengan nilai IC 50 sebesar 34,7 µg/ml dan relatif tidak toksik terhadap sel normal Vero dengan nilai IC 50 sebesar 1071,6 µg/ml. KATA KUNCI: rumput laut coklat, Padina australis, fukosantin, sitotoksisitas ABSTRACT Fucoxanthin is marine carotenoid that present in brown algae. It has considerable potential and promising application in human health. Padina australis is one of brown algae containing fucoxanthin. The aims of this research was to isolate fucoxanthin from P. australis and to investigate cytotoxicity against MCF7 cancer cell and Vero normal cell line. Fucoxanthin isolation was performed by using SiO 2 column chromatography. Fucoxanthin identification was done by using liquid chromatography ion trap time of flight mass spectrofotometer (LC-IT-ToF-MS) based on UV absorbance profile and molecular weight. Cytotoxicity test was evaluated by using

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“…Domoic acid derivatives from Chondria armata show larvicidal and blood pressure lowering activity [43]. The algal extracts have also been explores for their antiplasmodial activities, [38].…”

Section: Antiprotozoal and Antiplasmodial Activity Of Algaementioning

confidence: 99%

Bioactive Compounds Derived from Microalgae Showing Antimicrobial Activities

Sanmukh¹,

Bruno²,

Ramakrishnan³

et al. 2014

J Aquac Res Development

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Fucoxanthin, Tetraprenylated Toluquinone and Toluhydroquinone Metabolites from Sargassum heterophyllum Inhibit the in vitro Growth of the Malaria Parasite Plasmodium falciparum

Cited by 57 publications

References 17 publications

Antifouling activity as a function of population variation in Sargassum vulgare from the littoral of Rio de Janeiro (Brazil)

Antifouling activity as a function of population variation in Sargassum vulgare from the littoral of Rio de Janeiro (Brazil)

Isolasi Fukosantin dari Rumput Laut Coklat Padina australis dan Sitotoksisitasnya terhadap Sel MCF7 dan Sel Vero

Bioactive Compounds Derived from Microalgae Showing Antimicrobial Activities

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