It is well-known that x-phase precipitates embrittle Ti-5553 alloys and that x-phase embrittlement can be overcome with appropriate heat treatments. However, the microstructural evolution of electron-beam welded Ti-5553 is not as understood as compared to the cast or wrought material. This study compared the microstructures of as-welded and post-weld heat-treated specimens by scanning and transmission electron microscopy, and similarly compared the localized mechanical behavior of the fusion zones with microhardness testing and digital image correlation coupled tensile testing. The primary observations were that the embrittling x-phase precipitates formed upon cooling, and could not be fully solutionized in a single-step treatment of 1077 K (804°C) for 1 hour. It was also discovered that nanoscale a-phase precipitates nucleated after the single-step treatment, although they were small in number and sparsely distributed. However, a two-step heat treatment of 1077 K (804°C) for 1 hour and 873 K (600°C) for 4 hours completely solutionized the x-phase and produced a dense network of 2-lm-wide a-phase plates, which significantly improved the mechanical properties. Overall, this study has shown that post-weld heat treatments improve the strength and ductility of electron-beam welded Ti-5553 alloys by controlling x-and a-phase evolution.