Fully dynamic multiple-beam optical tweezers

Eriksen, René Lynge; Daria, Vincent Ricardo; Glückstad, Jesper

doi:10.1364/oe.10.000597

Cited by 175 publications

(105 citation statements)

References 16 publications

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“…The optical manipulation of microdroplets with a spot-array pattern provides parallel and flexible control of the microdroplets because real-time generation of the desired optical pattern is achievable with light-controlling devices such as an SLM (Eriksen et al 2002). This capability is valuable for adaptive control by designing appropriate light patterns to manipulate microdroplets according to the processing status.…”

Section: Resultsmentioning

confidence: 99%

“…They can be transported flexibly by adequate control of optical radiation pressure force (Gahagan et al 1998;Sasaki et al 1992) and fused (Lorenz et al 2007;Ogura et al 2011a) easily without using microfabricated structures. Independent and parallel manipulation of microdroplets is achievable by generating appropriate optical field patterns dynamically with a spatial light modulator (SLM) (Ogura et al 2011a;Prentice et al 2004;Eriksen et al 2002), and different compositions of DNA logic gates are configured at multiple positions simultaneously. The individual molecular elements are separated into different microdroplets and transported for the desired operation by optical manipulation.…”

Section: Optofluidic Dna Computationmentioning

confidence: 99%

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Optofluidic DNA computation based on optically manipulated microdroplets

Nishimura

Ogura

Tanida

2012

Microfluid Nanofluid

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DNA computing is a promising approach for dealing with biomolecular information. Although several DNA logic circuits which can evaluate biomolecular inputs have been proposed, they have serious drawbacks in the processing speed and the amount of molecules used in implementation. Here, we present optofluidic DNA computation as an effective method for constructing a DNA computing system. By confining the reaction space of DNA computation to the inside of a microdroplet and manipulating a group of droplets with external light signals, we improve usability of DNA computation as well as the processing performance. Optical manipulation is applied to transport the droplets and to initiate DNA computation by forced merging of the droplets. The proposed method has advantages over conventional DNA computation schemes in flexible operations, simultaneous multiplexed evaluation, and processing acceleration. As the first demonstration of optofluidic DNA computation, logical AND and OR operations are performed by optical manipulation of microdroplets which contain either DNA logic gates or input molecules. Also, considerable reduction in the processing time is confirmed on the optofluidic DNA computation owing to reduction of the reaction space to the microdroplet.

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Section: Resultsmentioning

confidence: 99%

Section: Optofluidic Dna Computationmentioning

confidence: 99%

Optofluidic DNA computation based on optically manipulated microdroplets

Nishimura

Ogura

Tanida

2012

Microfluid Nanofluid

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“…For the independent control of multiple zeolite L crystals, the concept of optical tweezers has to be expanded. [23][24][25][26] One of the most fl exible approaches are holographic optical tweezers (HOT), where the light fi eld is tailored with diffractive optical elements (DOE) such that a number of spatially arranged optical traps is generated. [ 26 ] It is this approach that we employ in our work to obtain dynamic patterning and reversible organization of zeolite L based on individual control of single crystals.…”

Section: Doi: 101002/adma201001453mentioning

confidence: 99%

Dynamic and Reversible Organization of Zeolite L Crystals Induced by Holographic Optical Tweezers

et al. 2010

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Organization and patterning of zeolite L crystals with their unique properties such as their one-dimensional nano channel system is of highest topical interest with various applications in many areas of science. We demonstrate full three-dimensional optical control of single zeolite L crystals and for the first time fully reversible, dynamic organization of a multitude of individually controlled zeolite L crystals.

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“…27 The correlated motions of two-interacting microspheres in dual-trap optical tweezers were measured. 23 Multibeam optical tweezers can be created by using spatial light modulators [28][29][30] and computer-controlled scanning reflectors. 31,32 However, biochemical properties of the interacting microscopic objects held in dual traps have not been explored.…”

Section: Introductionmentioning

confidence: 99%

Dual-trap Raman tweezers for probing dynamics and heterogeneity of interacting microbial cells

Wang

Yao

et al. 2010

J. Biomed. Opt.

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Abstract. We report on development of dual-trap Raman tweezers for monitoring cellular dynamics and heterogeneity of interacting living cells suspended in a liquid medium. Dual-beam optical tweezers were combined with Raman spectroscopy, which allows capturing two cells that are in direct contact or closely separated by a few micrometers and simultaneously acquiring their Raman spectra with an imaging CCD spectrograph. As a demonstration, we recorded time-lapse Raman spectra of budding yeast cells held in dual traps for over 40 min to monitor the dynamic growth in a nutrient medium. We also monitored two germinating Bacillus spores after the initiation with L-alanine and observed their heterogeneity in the release of CaDPA under identical microenvironment. C 2010 Society of Photo-Optical instrumentation Engineers.

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Fully dynamic multiple-beam optical tweezers

Cited by 175 publications

References 16 publications

Optofluidic DNA computation based on optically manipulated microdroplets

Optofluidic DNA computation based on optically manipulated microdroplets

Dynamic and Reversible Organization of Zeolite L Crystals Induced by Holographic Optical Tweezers

Dual-trap Raman tweezers for probing dynamics and heterogeneity of interacting microbial cells

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