Fulminant Septicaemic Syndrome of Bacillus cereus: Three case reports

Musa, Mohamed O; Douri, M. Al; Khan, Shakeel Ahmed; Shafi, Tahir; Humaidh, A. Al; Rasheed, Abdur

doi:10.1016/s0163-4453(99)90009-9

Cited by 39 publications

(22 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This type of opportunistic infection has been reported as fulminant B. cereus septicemia. [1][2][3][4][5][6][7][8] In 1993, we reported two patients with acute leukemia with fulminant B. cereus septicemia. 9 Here we report a patient with biphenotypic acute leukemia who died of fulminant septicemia with B cereus that was resistant to carbapenem.…”

Section: Kazunobu Kiyomizu · Toshinari Yagi · Hitoshi Yoshida Ryota Mmentioning

confidence: 99%

Fulminant septicemia of Bacillus cereus resistant to carbapenem in a patient with biphenotypic acute leukemia

Kiyomizu

Yagi

Yoshida

et al. 2008

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

Section: Kazunobu Kiyomizu · Toshinari Yagi · Hitoshi Yoshida Ryota Mmentioning

confidence: 99%

Fulminant septicemia of Bacillus cereus resistant to carbapenem in a patient with biphenotypic acute leukemia

Kiyomizu

Yagi

Yoshida

et al. 2008

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

“…We suspect that, becasue our patient was undergoing intrathecal chemotherapy, the frequent manipulation of the Ommaya reservoir led to bacterial contamination with B cereus and subsequent invasive disease. Previous cases of B cereus CNS disease have reported ventriculostomy tubes, ventricular punctures, central venous catheters, nasal feeding tubes and immunosuppression as risk factors (4,5,(6)(7)(8)(9)(10)(11)(12)(14)(15)(16)(17)(18)(19). Only Garcia et al (5) reported the presence of an Ommaya reservoir as a risk factor.…”

Section: Discussionmentioning

confidence: 99%

Meningitis due to Bacillus cereus: A Case Report and Review of the Literature

Stevens

Elam

Bearman

2012

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Bacillus cereus is infrequently associated with invasive central nervous system (CNS) disease. Infection is associated with conditions that lead to reduced host immunity and provide direct access to the CNS, such as spinal anesthesia and ventricular tubes and shunts. A case of ventriculitis secondary to B cereus in a patient receiving intrathecal chemotherapy is reported, along with a review of the current literature. B cereus can colonize medical devices, thus posing a risk for invasive disease. Despite aggressive treatment with broad-spectrum anti-infectives, the mortality of CNS invasive B cereus is high. Clinicians should not dismiss Gram-positive rods resembling Bacillus species from normally sterile sites as contaminants in critically ill patients. Appropriate antibiotic therapy should be promptly initiated to limit morbidity and mortality. acillus cereus is a spore-forming, Gram-positive, or Gram-variable, rod bacterium that is ubiquitous in the environment. It is a wellknown cause of gastrointestinal illness, but has been associated with extraintestinal disease, as well (1). Central nervous system (CNS) involvement with B cereus is rare, but has been described in association with both immunosuppression and CNS invasive devices. B cereus is intrinsically resistant to beta-lactam antibiotics (1), and CNS infections with this organism are associated with high mortality. A case involving a 73-year-old woman with chronic myelogenous leukemia and an Ommaya reservoir who developed ventriculitis with B cereus is reported, along with a review of the literature on invasive CNS infections with B cereus. CASE PrESEntAtIonA 73-year-old Afghani woman with a history of chronic myelogenous leukemia, complicated by leukemic meningitis, on therapy with bosutinib (an experimental tyrosine kinase inhibitor) and monthly intrathecal methotrexate and hydrocortisone administered via an Ommaya reservoir, presented to her oncology clinic for a scheduled intrathecal methotrexate/hydrocortisone infusion. On presentation, the patient was clinically well and her cerebrospinal fluid (CSF) revealed no white blood cells. One day later, she developed headache, generalized weakness and confusion and presented to the emergency department. She was tachycardic, febrile (38.7°C), lethargic, had nuchal rigidity and a systolic murmur (grade 3/6) at the left sternal border. She had leukocytosis with a leukocyte count of 19.2×10 9 cells/L with 96% neutrophils, and CSF analysis revealed 4.02×10 9 /L white blood cells with 99% neutrophils, a protein level of 1.21 g/L, and a glucose level of 4.88 mmol/L. A gram-stain of teh CSF revealed Gramvariable rod bacteria (Figure 1). Blood and CSF cultures were sent for analysis and empirical therapy with vancomycin and cefepime was initiated. By hospital day 2, both the headache and her mental status had improved. Blood and CSF cultures grew B cereus, which was susceptible to vancomycin. The Ommaya reservoir was removed on hospital day 3. Repeat blood cultures were negative and she underwent transesophageal ...

show abstract

“…The poor outcomes in acute leukemia patients may have been an indirect consequence because of the greater immunosuppression following intensive chemotherapy, rather than due to the underlying disease. Regarding the relationship between B. cereus sepsis and the treatment process of acute leukemia in the combined clinical parameters, 35 patients developed sepsis during remission induction or reinduction therapy, 9 consolidation therapy, 4 posttransplantation, and 1 maintenance therapy in a total of 49 acute leukemia patients whose clinical data were available (Akiyama, et al 1997, Arnaout, et al 1999, Christenson, et al 1999, Colpin, et al 1981, Cone, et al 2005, Coonrod, et al 1971, Dohmae, et al 2008, Feldman and Pearson 1974, Frankard, et al 2004, Funada, et al 1988, Garcia, et al 1984, Gaur, et al 2001, Ginsburg, et al 2003, Ihde and Armstrong 1973, Jenson, et al 1989, Katsuya, et al 2009, Kawatani, et al 2009, Kiyomizu, et al 2008, Kobayashi, et al 2005, Kuwabara, et al 2006, Le Scanff, et al 2006, Leff, et al 1977, Marley, et al 1995, Motoi, et al 1997, Musa, et al 1999, Nishikawa, et al 2009, Ozkocaman, et al 2006, Sakai, et al 2001, Strittmatter, et al 1995,…”

Section: Discussion and Proposal 231 How Do We Efficiently Select Hmentioning

confidence: 99%

“…To our knowledge, 46 B. cereus sepsis patients with hematologic malignancies have been previously reported (Akiyama, et al 1997, Arnaout, et al 1999, Christenson, et al 1999 et al 1981, Cone, et al 2005, Coonrod, et al 1971, Dohmae, et al 2008, Feldman and Pearson 1974, Frankard, et al 2004, Funada, et al 1988, Garcia, et al 1984, Gaur, et al 2001, Ginsburg, et al 2003, Ihde and Armstrong 1973, Jenson, et al 1989, Katsuya, et al 2009, Kawatani, et al 2009, Kiyomizu, et al 2008, Kobayashi, et al 2005, Kuwabara, et al 2006, Le Scanff, et al 2006 www.intechopen.com al 1977, Marley, et al 1995, Motoi, et al 1997, Musa, et al 1999, Nishikawa, et al 2009, Ozkocaman, et al 2006, Sakai, et al 2001, Strittmatter, et al 1995, Tomiyama, et al 1989, Trager and Panwalker 1979, Yoshida, et al 1993. On analyses of the clinical parameters of these patients, as in shown in Table 2, patients with acute leukemia, a neutrophil count of 0/mm 3 or below the lower limit of each institute, or CNS symptoms at febrile episodes were identified as risk factors closely correlated with a fatal prognosis (P=0.044, 0.004, and 0.002, respectively).…”

Section: Risk Factors For a Fatal Prognosis In Previously Reported Pamentioning

confidence: 98%