Fumaric acid esters in dermatology

Wollina, Uwe

doi:10.4103/2229-5178.86007

Cited by 31 publications

(26 citation statements)

References 41 publications

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“…The main side effects associated with FAEs include gastrointestinal, flushing, reversible elevation of transaminases, lymphocytopenia, and eosinophilia. 125 Antimalarials are often used in the treatment of generalized GA. Chloroquine (250 mg daily) was successfully used in a patient with photodistributed GA. 126 Hydroxychloroquine has been used in the treatment of generalized GA. 127,128 Cannistraci and colleagues 127 treated 9 patients with generalized GA with 4 months of hydroxychloroquine (9 mg/kg/d for 2 months; 6 mg/kg/d for month 3; and 2 mg/kg/d for month 4). In this series of patients, complete remission was seen in all patients within 6 to 7 weeks of initiation of therapy.…”

Section: Evaluation and Managementmentioning

confidence: 99%

Granuloma Annulare

Keimig

2015

Dermatologic Clinics

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Granuloma annulare (GA) is a noninfectious granulomatous skin condition that can present with a variety of cutaneous morphologies. It is characterized by collagen degeneration, mucin deposition, and palisaded or interstitial histiocytes. Although the mechanism underlying development of GA is unknown, studies point to a cell-mediated hypersensitivity reaction to an as-yet undetermined antigen. Systemic associations with diabetes, thyroid disorders, lipid abnormalities, malignancy, and infection are described in atypical GA. Treatment is divided into localized skin-directed therapies and systemic immunomodulatory or immunosuppressive therapies. The selected treatment modality should be based on disease severity, comorbid conditions, consideration of potential side effects, and patient preference.

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Section: Evaluation and Managementmentioning

confidence: 99%

Granuloma Annulare

Keimig

2015

Dermatologic Clinics

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“…Treatment with FAEs has been reported to be effective not only in patients with sarcoidosis but also with other granulomatous diseases, such as disseminated granuloma annulare and necrobiosis lipoidica [5,6,7]. Recently, four cases with virus-related progressive multifocal encephalopathy (PML) were reported in patients with psoriasis under FAEs treatment [15].…”

Section: Discussionmentioning

confidence: 99%

“…Beyond that, several reports have described an effect of FAEs on granulomatous skin diseases such as sarcoidosis, necrobiosis lipoidica and granuloma annulare [5,6,7]. However, very little is known about their mechanism(s) of action.…”

Section: Introductionmentioning

confidence: 99%

Multi-Organ Sarcoidosis Treatment with Fumaric Acid Esters: A Case Report and Review of the Literature

Zouboulis

Lippert²,

Karagiannidis³

2014

Dermatology

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Sarcoidosis is a rare, systemic disease that is characterized by the formation of granulomas in various organs, including the skin. As the etiology remains unknown, the treatment of sarcoidosis is challenging. We present a 47-year-old female patient with progressive, multi-organ sarcoidosis who had a complete clinical improvement of the skin lesions, a moderate reduction in pulmonary opacities on chest X-ray, a marked subjective improvement in general status and pulmonary efficiency and a marked reduction in serum angiotensin-converting enzyme and soluble interleukin-2 receptor after 6 months of therapy with fumaric acid esters. The present case and similar reports in the literature highlight the probable efficacy of fumaric acid esters in the treatment of sarcoidosis and other non-infectious, granulomatous diseases.

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“…9 Other diseases, such as necrobiosis lipoidica, granuloma annulare, and sarcoidosis were also found in case reports or small patient series to respond to treatment with DMF. 28 Recently, Phase III clinical trials found that DMF (BG-12) successfully reduced the relapse rate and time to progression of disability in people with multiple sclerosis.…”

Section: Discussionmentioning

confidence: 99%

Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system

Liu

Qiu

Wang

et al. 2015

JNS

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S ubarachnoid hemorrhage (SAH) is a critical neurosurgical phenomenon that is often coupled with several interrelated complications such as acute/delayed cerebral vasospasm, brain edema, obstructive/communicating hydrocephalus, diffuse/focal cerebral ischemia or infarction, and lasting cognitive deficits. 22,25 In China, the SAH-related morbidity rate is about 1.75 per 10,000. 30Despite recent progress in microsurgical and endovascular surgical techniques, the outcome of patients who suffer an SAH remains disappointing.abbreviatioNs ARE = antioxidant-responsive element; DMF = dimethylfumarate; EBI = early brain injury; ELISA = enzyme-linked immunosorbent assay; EMSA = electrophoretic mobility shift assay; FJB = Fluoro-Jade B; GSH-Px = glutathione peroxidase; GST-α1 = glutathione S-transferase α1; HO-1 = heme oxygenase 1; IL = interleukin; Keap1 = Kelch-like ECH-associated protein 1; MDA = malondialdehyde; MWM = Morris water maze; NQO1 = quinone oxidoreductase 1; Nrf2 = nuclear factor erythroid 2-related factor 2; PBS = phosphate-buffered saline; SAH = subarachnoid hemorrhage; SOD = superoxide dismutase; TNFα = tumor necrosis factor-α. obJect Oxidative stress and the inflammatory response are thought to promote brain damage in the setting of subarachnoid hemorrhage (SAH). Previous reports have shown that dimethylfumarate (DMF) can activate the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant-responsive element (Keap1-Nrf2-ARE) system in vivo and in vitro, which leads to the downregulation of oxidative stress and inflammation. The aim of this study was to evaluate the potential neuroprotective effect of DMF on SAH-induced brain injury in rats. methods Rats were subjected to SAH by the injection of 300 ml of autologous blood into the chiasmatic cistern. Rats in a DMF-treated group were given 15 mg/kg DMF twice daily by oral gavage for 2 days after the onset of SAH. Cortical apoptosis, neural necrosis, brain edema, blood-brain barrier impairment, learning deficits, and changes in the Keap1-Nrf2-ARE pathway were assessed. results Administration of DMF significantly ameliorated the early brain injury and learning deficits induced by SAH in this animal model. Treatment with DMF markedly upregulated the expressions of agents related to Keap1-Nrf2-ARE signaling after SAH. The inflammatory response and oxidative stress were downregulated by DMF therapy. coNclusioNs DMF administration resulted in abatement of the development of early brain injury and cognitive dysfunction in this prechiasmatic cistern SAH model. This result was probably mediated by the effect of DMF on the Keap1-Nrf2-ARE system.

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Fumaric acid esters in dermatology

Cited by 31 publications

References 41 publications

Granuloma Annulare

Granuloma Annulare

Multi-Organ Sarcoidosis Treatment with Fumaric Acid Esters: A Case Report and Review of the Literature

Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system

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