Fumaric acid protect the cadmium-induced hepatotoxicity in rats: owing to its antioxidant, anti-inflammatory action and aid in recast the liver function

Kaur, Gurinder; Thippeswamy, B.S.; Kumar, Manish; Kushwah, Ajay Singh

doi:10.1007/s00210-020-01900-7

Cited by 29 publications

(18 citation statements)

References 26 publications

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“…Otherwise, rodents fed with silymarin or green tea expressively condensed cell propagation by means of a reduction in PCNA stain. In the scientific literatures, enormous number of medicinal plants with hepatoprotective potential has been pronounced by several investigators ( Bardi et al, 2014 , Salama et al, 2018 , Kaur et al, 2020 , Abood et al, 2020 , Elnfarawy et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Liver is principal interior and metabolically active structure in human being is that play energetic role in digestion, secretion, blood detoxification, and storage of numerous nutrients and minerals. Due to these fundamental roles of liver in human body, hepatic disorders remain to be amongst the major world public health problem ( Abood et al, 2020 , Kaur et al, 2020 , Chen et al, 2021 ). Therefore, discovery of most effective and less toxic treatment for liver diseases have been increasingly gaining attention.…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective effects of methanolic extract of green tea against Thioacetamide-Induced liver injury in Sprague Dawley rats

Shareef

Ibrahim

Alzahrani

et al. 2022

Saudi Journal of Biological Sciences

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Ethnopharmacological relevance Since ancient times, herbal medicines have been applied in the treatment of cancer. Tea, derivative from the dried leaves of Camellia sinensis (L.) Kuntze plant is the most popular beverage globally after water and is available in various forms. Green tea has been expansively investigated for its beneficial properties of cancer prevention and therapy. The goal of the research: The current study was conducted to evaluate the hepaprotective character of methanolic green tea extract and its mechanism of action contrary to thioacetamide (TAA)-produced liver fibrosis of Sprague Dawley rats. Materials and Methods Thirty rodents were equally placed in 5 clusters including normal control, TAA group as a positive control, silymarin as standard drug control, and treatment groups consisting of high dose and a low dose Camellia sinensis. Rats in experimental clusters by mouth fed with C. sinensis at 250 mg/kg or 500 mg/kg daily for 2 months. After 60 days, all rats were sacrificed. Blood specimens were gathered for liver biochemical examination. Livers of all groups were dissected out and subjected to histopathological examination through the Hematoxylin and Eosin stain, Masson trichrome, and immunohistochemistry stains (PCNA). Liver tissue homogenate was also analyzed for antioxidant activity parameters. Results Gross morphological examination showed a regular liver architecture in C. sinensis fed collections compared to the TAA sets. Histology of rat’s liver fed with C. sinensis showed an important decrease in the liver index with hepatic cells propagation, mild cellular injury, and immunostaining showed significant down-expression of proliferating cell nuclear antigen (PCNA). TAA produced liver fibrosis through a significant increase in serum alanine transferase, aspartate aminotransferase, alkaline phosphatase, and bilirubin. Total protein and albumin also decreased in the TAA group. Moreover, the reduction of antioxidant enzyme activity including superoxide dismutase and catalase as well as the increase in malondialdehyde was detected in the TAA control group. Meanwhile, an abnormal level of liver biochemical parameters was restored closer to the normal levels in serum of the C. sinensis-fed clusters. In addition, C. sinensis fed assemblies showed elevated antioxidative enzymes activity with a reduction in malondialdehyde level comparable to the levels in silymarin-treated rats. Conclusions Green tea potentially inhibited the progression of liver cirrhosis, down -regulation of PCNA proliferation, prevented oxidation of hepatocytes, recovered SOD and CAT enzymes, condensed MDA and reduced cellular inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of methanolic extract of green tea against Thioacetamide-Induced liver injury in Sprague Dawley rats

Shareef

Ibrahim

Alzahrani

et al. 2022

Saudi Journal of Biological Sciences

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“…In studies on the toxicity of cadmium, it has been shown that the serum hepatic marker enzymes AST, ALT and ALP activities are increased. Hydrogen cyanide toxicity occurs as a result of enzymatic destruction of cyanogenic glycosides contained in plants such as flaxseed (27)(28)(29)(30). The elevation of hepatic markers is also notable in the hepatotoxicity study conducted with linamarin, which is a cyanogenic glycosides (31).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that in rats treated with cadmium, the balance of prooxidant / antioxidant was disrupted, lipid peroxidation increased, and total antioxidant capacity decreased (28,29). Cyanide hepatotoxicity increases oxidation with a similar effect to cadmium while reducing the antioxidant parameters (33).…”

Section: Discussionmentioning

confidence: 99%

Aşiri Doz Keten Tohumu (Linum Usitatissimum L.) Tüketi̇mi̇ Ratlarda Karaci̇ğer Hasarina Neden Olur Mu?

Özgöçmen

Yeşilot

2021

SDÜ Tıp Fakültesi Dergisi

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AmaçDoğal sağlık ürünleri ve fonksiyonel gıdalar, birçok hastalığın önlenmesi ve tedavisi için tüketilmektedir. Keten tohumu antikanser, antiviral, antibakteriyel ve antifungal özelliklere sahip fonksiyonel gıdalardan biridir. Yararlı etkilerinin yanı sıra bilinçsiz ve aşırı tüketilmesi toksik etkilere neden olabilmektedir. Bu çalışmada, farklı miktarlarda keten tohumu tüketiminin sıçan karaciğeri üzerindeki etkilerinin araştırılması planlanmıştır. Gereç ve YöntemSıçanlar; her grupta 8 adet olarak; kontrol grubu ve 7 gün süreyle sırasıyla; 1.4, 2.8 ve 5.6 g/kg/gün keten tohumu verilen deney grupları şeklinde dört gruba ayrılmıştır. Deney sonunda doku ve kan örneklerinde histolojik, immünohistokimyasal ve biyokimyasal analizler yapılmıştır. BulgularSerum AST, ALT ve ALP değerleri 5,6 g/kg keten tohumu verilen grupta kontrol grubuna göre anlamlı olarak daha yüksek gözlendi (p değerleri 0.003, 0.012 ve 0.009). Albümin değerleri deney gruplarında kontrol grubuna göre anlamlı olarak düşük gözlendi (p<0.05). TOS ve OSI kontrole göre tüm deney gruplarında anlamlı olarak artmış (p<0.05), TAS ise azalmıştı (p>0.05). Kontrol grubu ile deney grupları arasında histopatolojik bulgular arasında anlamlı farklar bulundu. Özellikle 5.6 g/kg keten tohumu grubunda tüm gruplara göre daha fazla histopatolojik bulgulara rastlandı. İmmünohistokimyasal analizlerde, en fazla boyama yoğunluğu 5,6 g/kg keten tohumu grubunda gözlemlendi. En yüksek pozitif boyanmaya sırasıyla NOX 4 , iNOS, TNF-α ve IL-6 boyanmalarında rastlandı. SonuçAşırı keten tohumu tüketiminin oksidatif stres ve toksisiteye bağlı olarak karaciğerde iltihaplanmaya neden olabileceği ve çalışmanın keten tohumu toksisitesi ile ilgili diğer çalışmalara katkı sağlayacağı düşünülmektedir.

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“…Several reports indicated that the hepatotoxicity of Cd was attributed mainly ROS generation, protein, lipid peroxidation, and in ammation since the main mode of action of this metal is the generation of ROS and the diminish of the antioxidant defense system (SOD, CAT, GSH, and GPx) (Andjelkovic et al 2019;Rahimzadeh et al 2017). The generation of ROS including hydroxyl, hydrogen peroxide, and superoxide radicals modulate different components in the cell components mainly protein, lipids, and carbohydrates leading to the discrepancy of the metabolic dysfunction and cell integrity (Kaur et al 2020). Moreover, MDA is a well-known player of lipid peroxide, whose malignant activities lead to injury to parenchymal cells (Andjelkovic et al 2019) and its forms interfere with many biomolecules such as DNA, acetaldehyde, and the advanced glycation end products that comprise cell integrity (Li et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Bioactive Phytochemicals From Salvia Officinalis Attenuate Cadmium-induced Oxidative Damage and Genotoxicity in Rats

Rashwana

Mohammed

El‐Nekeety

et al. 2021

Preprint

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This study was conducted to identify the bioactive phytochemicals in Salvia officinalis essential oil, to determine the polyphenols in the aqueous extract (SOE), and to evaluate their protective role against cadmium (Cd)-induced oxidative damage, and genotoxicity in rats. Six groups of female rats were treated orally for 2 weeks including the control group, CdCl2-treated group, SOE-treated groups at low or high dose (100 and 200 mg/kg b.w), and CdCl2 plus SOE-treated groups at the two doses. The GC-MS analysis identified 39 compounds the main compounds were 9-Octadecenamide, Eucalyptol, Palmitic acid, Oleic acid. However, the HPLC analysis identified 12 polyphenolic compounds and the majority were coumaric acid, chlorogenic acid, coffeic acid, catechin, vanillin, gallic acid, ellagic acid, and rutin. In the biological study, rats received CdCl2 displayed severe disturbances in liver and kidney indices (ALT, AST, Alb, TP, T. Bil, D. Bil, creatinine, uric acid, and urea), lipid profile (Cho, TG, HDL, and LDL), serum cytokines (TNF-α, AFP and CEA), antioxidant enzymes (GSH, GPx, SOD and CAT), oxidative stress markers (MDA and NO), gene expressions, DNA fragmentation, and histological alterations in the liver and kidney tissue. SOE showed a potent antioxidant and mitigated these alterations in serum and tissue. Moreover, the high dose succeeded to normalize most of the tested parameters and histological features. It could be concluded that Salvia officinalis is a promising source for bioactive compounds with therapeutically benefits against environmental toxicants.

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Fumaric acid protect the cadmium-induced hepatotoxicity in rats: owing to its antioxidant, anti-inflammatory action and aid in recast the liver function

Cited by 29 publications

References 26 publications

Hepatoprotective effects of methanolic extract of green tea against Thioacetamide-Induced liver injury in Sprague Dawley rats

Hepatoprotective effects of methanolic extract of green tea against Thioacetamide-Induced liver injury in Sprague Dawley rats

Aşiri Doz Keten Tohumu (Linum Usitatissimum L.) Tüketi̇mi̇ Ratlarda Karaci̇ğer Hasarina Neden Olur Mu?

Bioactive Phytochemicals From Salvia Officinalis Attenuate Cadmium-induced Oxidative Damage and Genotoxicity in Rats

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