Functional and morphological features of the adrenal cortex of albino rats after long exposure to styrene

Prochukhanov, R. A.; Сафинова, Л. Ш.

doi:10.1007/bf00827468

Bull Exp Biol Med

1981

DOI: 10.1007/bf00827468

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Functional and morphological features of the adrenal cortex of albino rats after long exposure to styrene

R. A. Prochukhanov¹,

Л. Ш. Сафинова²

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1996

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“…In the second series (n=20), stress was applied after treatment with metapyrone (SU-4885, CIBA-Geygy). This agent blocks hyperfunction of adrenal cortex and in a dose of 11 mg/100 g body weight maintains blood glucocorticoids at the baseline level [4,10]. Metapyrone was injected one day before the first stressful situation.…”

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Functional activity of spleen and peripheral blood lymphocytes in stress-induced immunodepression

Ягмуров

Ogurtsov

1996

Bull Exp Biol Med

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Study of lymphoid organs and T and B cells in white rats shows that long-term stress causes progressive suppression of the immune response. Blockade of steroid hormone synthesis in the adrenal cortex prevents the development of immunodepression, implying a protective effect of such t, blockade against stress-related secondary immunodeficiency. Key Words: stress: h'mphm'ytes; immunodepression; metapyroneStress-related secondary immunodepre_~ton is a consequence of increased production or steroid hormones by the adrenal cortex under the ~nflu-ence of adrenocorticoid hormone 12.3.51 High concentrations of glucocorticoids suppres~ the immune responses [14]. There is e~idencc suggesting that glucocorticoids and other bmlogically active substances produce a direct effect on the lymphoid tissue and peripheral blood lymphocytes [6][7][8][11][12][13]. It was shown that the immune response is associated with proliferation of the effector cells [1,6,9]. This suggests tha', dtm,nished function of the immune system in stress-related imbalance of hormones results from changes in the population of lymphocytes and their activity. In this connection, physiological stabilization of stress-related hyperactivity of the adrenal cortex is of interest [4,101.Our aim was to study the populations of and functional state of spleen and peripheral blood lymphocytes in stress-induced immunodepression and during physiological stabilization of changes in the balance of hormones. MATERIALS AND METHODSExperiments were performed on outbred male albino rats weighing 180-220 g (n=45). Stress was modelled by hyperkinesia achieved by forced swimming for a long time. Three series of experiments were performed. In the first series, rats (n--20) were exposed to stress. In the second series (n=20), stress was applied after treatment with metapyrone (SU-4885, CIBA-Geygy). This agent blocks hyperfunction of adrenal cortex and in a dose of 11 mg/100 g body weight maintains blood glucocorticoids at the baseline level [4,10]. Metapyrone was injected one day before the first stressful situation. Five rats which were given normal saline and were not exposed to stress served as a control. The experiment was carried out for 4 weeks, and material was collected at the end of each week (on day 7). The rats were killed by decapitation on days 7, 14, 21, and 28. Histological investigation of the lymphoid tissue (spleen and Peyer's patches of the small intestine) and quantitative analysis of immunocompetent cells in the T and B zones were performed on paraffin sections by the method of Avtandilov. The sections were stained with hematoxylin-eosin and picrofuchsin after Van Gieson. The enzyme activity of specific cells and endothelial cells of splenic sinu-

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confidence: 99%

Functional activity of spleen and peripheral blood lymphocytes in stress-induced immunodepression

Ягмуров

Ogurtsov

1996

Bull Exp Biol Med

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Functional and morphological features of the adrenal cortex of albino rats after long exposure to styrene

Cited by 1 publication

References 0 publications

Functional activity of spleen and peripheral blood lymphocytes in stress-induced immunodepression

Functional activity of spleen and peripheral blood lymphocytes in stress-induced immunodepression

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