Functional and Structural Analysis of the Visual System in the Rhesus Monkey Model of Optic Nerve Head Ischemia

Brooks, Dennis; Källberg, M. E.; Cannon, Richard L.; Komàromy, András M.; Ollivier, Franck J.; Malakhova, O. E.; Dawson, William W.; Sherwood, Mark B.; Kuekuerichkina, Elen E; Lambrou, George N.

doi:10.1167/iovs.03-0950

Cited by 25 publications

(34 citation statements)

References 39 publications

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“…Analysis of the results shows that c-Fos expression is activity dependent, inasmuch as there is a clear reduction of c-Fos labeling in the layers corresponding to the lesioned eye. No c-Fos labeling was observed in the LGN of Macaca mulatta (Brooks et al, 2004). This discrepancy could be due to interspecies differences or to the different antibodies used in these studies.…”

Section: Discussionmentioning

confidence: 73%

Differential expression of Zif268 and c‐Fos in the primary visual cortex and lateral geniculate nucleus of normal Cebus monkeys and after monocular lesions

Soares

Pereira

Botelho

et al. 2004

J of Comparative Neurology

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The transcription factors c-Fos and Zif268 have been used as markers of neuronal activity, and they also have been implicated in neuronal plasticity. In this study, we investigated the expression of c-Fos and Zif268 proteins in the lateral geniculate nucleus (LGN) and in the cortical primary visual area (V1) of normal adult Cebus apella monkeys and in animals with monocular lesions. In the LGN, the reaction for c-Fos showed immunopositive cells in both magnocellular (M) and parvocellular (P) layers; however, the label was heavier in P layers. In animals that suffered monocular lesions, the immunocytochemistry for c-Fos showed more labeling in layers related to the normal eye compared with those of the lesioned eye. No specific label was observed after the reaction for Zif268 in the LGN. In V1, the reaction for both Zif268 and c-Fos showed a pattern of lamination in which heavier labeling was found in layers 2/3, 4A, 4C, and 6. After monocular lesions, we observed a clear pattern of ocular dominance columns in V1 for both c-Fos and Zif268, in which the columns related to the normal eye are more heavily labeled than those related to the lesioned eye. This pattern is more evident in layer 4C after c-Fos reaction, whereas, after Zif268, it is more clearly observed in layers 2/3. These results suggest that, in addition to be regulated by functional activity, these transcription factors are involved in different processes during cortical reorganization.

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Section: Discussionmentioning

confidence: 73%

Differential expression of Zif268 and c‐Fos in the primary visual cortex and lateral geniculate nucleus of normal Cebus monkeys and after monocular lesions

Soares

Pereira

Botelho

et al. 2004

J of Comparative Neurology

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“…These effects can partly be explained by the caused vasoconstriction of the optic disc and retinal microvessels. Some studies, using different animal models, could successfully provoke an optic disc impairment and enlargement of the excavation through ET-1 induced ischemia [18,19]. Another damaging mechanism of ET-1 on the optic disc is proposed by Prasanna et al [12,20].…”

Section: Introductionmentioning

confidence: 99%

Plasma endothelin-1 and endothelin-A receptor concentrations in patients with primary open-angle glaucoma

Mihaylova

Petkova

Rankova-Yotova

et al. 2017

Biotechnology & Biotechnological Equipment

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Endothelin-1 (ET-1) is a potent vasoconstrictor and is considered to have a key role in the regulation of ocular perfusion and glaucoma pathogenesis. High ET-1 and ET A -receptor levels are reported in patients with primary open-angle glaucoma (POAG). We compared the mean plasma ET-1 and ET Areceptor concentration of controls and patients with early and advanced POAG stage, and assessed the correlation with the retinal nerve fibre layer (RNFL) thickness. The study included a total of 75 participants, aged 45-83 years: 25 (controls), 22 (early glaucoma) and 28 (advanced glaucoma). The plasma concentration of ET-1 and ET A -receptor was determined by enzyme-linked immunosorbent assay. The RNFL thickness was evaluated with spectral-domain optical coherence tomography. The mean ET-1 concentration was lower in the control group (4.88 § 1.75 pg/mL) than in the early and advanced POAG group (6.33 § 2.38 and 6.34 § 1.56 pg/mL). Statistically significant difference was found between the mean ET-1 concentrations in controls and glaucoma patients (p = 0.029 -early glaucoma, p = 0.018 -advanced glaucoma), and no significant difference was observed between the two POAG groups (p = 0.998). The mean ET A -receptor concentration was highest in the control group (1209.28 § 314.48 pg/mL) and the differences between the three groups were significant. Significant relationship was found only between ET-1 and RNFL. This study demonstrated the role of ET-1 in glaucoma pathogenesis based on the observed significant high ET-1 and ET A -receptor plasma levels in POAG patients. A new therapeutical approach needs to be considered in some patients.

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“…Other researchers also reported that the neuronal degeneration and activity of V1 and LGN greatly reduced the metabolic activity within V1 in glaucoma patients. (Brooks et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients

Nasaruddin¹,

Yusoff

Kaur

2017

JSKM

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The purpose of this study was to characterize, differentiate and correlate visual field and brain activation in visual cortex for normal, glaucoma suspect (GS) and primary open angle glaucoma (POAG) participants using Standard Tujuan kajian ini adalah untuk mencirikan, membezakan dan mengaitkan antara medan penglihatan dan pengaktifan otak dalam korteks penglihatan individu normal, suspek glaukoma (GS) dan glaukoma sudut terbuka primer (POAG) masingmasing menggunakan automasi perimetri piawai (SAP) dan pengimejan resonans magnet kefungsian (fMRI). Imbasan fMRI dan ujian SAP dilakukan di Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM). Dua jenis rangsangan penglihatan

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Functional and Structural Analysis of the Visual System in the Rhesus Monkey Model of Optic Nerve Head Ischemia

Cited by 25 publications

References 39 publications

Differential expression of Zif268 and c‐Fos in the primary visual cortex and lateral geniculate nucleus of normal Cebus monkeys and after monocular lesions

Differential expression of Zif268 and c‐Fos in the primary visual cortex and lateral geniculate nucleus of normal Cebus monkeys and after monocular lesions

Plasma endothelin-1 and endothelin-A receptor concentrations in patients with primary open-angle glaucoma

Functional MRI Characteristics in Visual Cortex (BA 17, 18 and 19) Corresponding to the Visual Field of Normal, Glaucoma Suspect (GS) and Primary Open Angle Glaucoma (POAG) Patients

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