2007
DOI: 10.1038/sj.onc.1210319
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Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells

Abstract: The inheritance of one defective BRCA1 or BRCA2 allele predisposes an individual to developing breast and ovarian cancers. BRCA1 is a multifunctional tumor suppressor protein, which through interaction with a vast array of proteins has implications in processes such as cell cycle, transcription, DNA damage response and chromatin remodeling. Conversely, the oncogene, cyclin D1 is overexpressed in about 35% of all breast cancer cases. In this study, we provide detailed analyses on the phosphorylation state of BR… Show more

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Cited by 41 publications
(28 citation statements)
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“…In sharp contrast, high ectopic levels of cyclin D1 in mammary epithelial cells and breast tumour cell lines markedly increase cell sensitivity to apoptosis induced by various agents (Han et al, 1996;Coco Martin et al, 1999;Niu et al, 2001). These discrepant observations may be due to the elevated and persistent production of cyclin D1 in some of these models, promoting apoptosis induction (Duquesne et al, 2001), and the functional regulation of the tumour suppressor protein BRCA1 by cyclin D1/ CDK4 complexes (Kehn et al, 2007). Using an original model of ectopic cyclin D1 production in the pre-B cell line BaF3, we reproduced a similar pattern of sensitivity/resistance to most of these anti-cancer drugs.…”
Section: Discussionmentioning
confidence: 71%
“…In sharp contrast, high ectopic levels of cyclin D1 in mammary epithelial cells and breast tumour cell lines markedly increase cell sensitivity to apoptosis induced by various agents (Han et al, 1996;Coco Martin et al, 1999;Niu et al, 2001). These discrepant observations may be due to the elevated and persistent production of cyclin D1 in some of these models, promoting apoptosis induction (Duquesne et al, 2001), and the functional regulation of the tumour suppressor protein BRCA1 by cyclin D1/ CDK4 complexes (Kehn et al, 2007). Using an original model of ectopic cyclin D1 production in the pre-B cell line BaF3, we reproduced a similar pattern of sensitivity/resistance to most of these anti-cancer drugs.…”
Section: Discussionmentioning
confidence: 71%
“…CycD1 has been reported to inhibit PPARγ-mediated adipogenesis via HDAC recruitment (6). CycD1/CDK4 was also shown to phosphorylate and inhibit the DNA-binding ability of BRCA1 in breast cancer cells (46). Interestingly, a genome-wide location approach revealed association of CycD1 with regulatory genomic regions enriched for binding sites of nuclear effectors of growth factor signaling (5).…”
Section: Discussionmentioning
confidence: 99%
“…Many Fox family genes, such as FoxA , FoxQ , FoxC , FoxM , and FoxO , have been shown to play an important role in the genesis, progression, and cell dissemination of certain cancers 1217,31,32. Previous evidences suggest that Foxj2 is abnormally expressed in various malignancies and is involved in positively regulating the progression of the cell cycle or actively participating in the metastatic process 20. The current study extended these findings by investigating Foxj2 expression and functions in NPC tissues and cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…Forkhead box J2 ( Foxj2 ), a member of this family formerly named as FHX, has dual DNA-binding specificity 18. Previous studies have shown its biological importance in mouse embryogenesis and tumorigenesis 19,20. The expression patterns of Foxj2 have been reported to be aberrant in a variety of cancers, such as breast cancer, extrahepatic cholangiocarcinoma, glioma, non-small cell lung cancer 2124.…”
Section: Introductionmentioning
confidence: 99%