Functional Effect of Platelet Membrane Glycoprotein Ia Gene Polymorphism in the Pathogenesis of Unstable Angina Pectoris

Zhao, Yanjie; Yang, Xu; Yy, Gu; Y, Li; Zhang, Junyi; X, Su

doi:10.1177/147323001103900223

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…Different frequencies of the rs1801106 polymorphism among various ethnic groups may explain the contradictory results. In the Chinese Han ethnic population, the prevalence of carriers of the 807T allele was markedly higher in patients with unstable angina pectoris (UAP) (129). In this population, the lag time to achieve a 30 % platelet aggregation was significantly longer in CC genotype than in TC genotype carriers, although there was no significant difference in maximal platelet aggregation among healthy subjects with either genotype.…”

Section: Platelet Glycoprotein Ia (Gpia)mentioning

confidence: 89%

Biomarkers for arterial and venous thrombotic disorders

Mannhalter

2014

Hamostaseologie

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SummaryThe haemostatic system maintains the blood in a fluid state, but allows rapid clot formation at sites of vascular injury to prevent excessive bleeding. Unbalances within the haemostatic system can lead to thrombosis. Inspite of successful research our understanding of the disease pathogenesis is still incomplete. There is great hope that genetic, genomic, and epigenetic discoveries will enhance the diagnostic capability, and improve the treatment options. During the preceding 20 years, the identification of polymorphisms and the elucidation of their role in arterial and venous thromboses became an important area of research. Today, a large body of data is available regarding associations of single nucleotide polymorphisms (SNPs) in candidate genes with plasma concentrations and e. g. the risk of ischaemic stroke or myocardial infarction. However, the results for individual polymorphisms and genes are often controversial. It is now well established that besides acquired also hereditary risk factors influence the occurrence of thrombotic events, and environmental factors may add to this risk. Currently available statistical methods are only able to identify combined risk genotypes if very large patient collectives (>10 000 cases) are tested, and appropriate algorithms to evaluate the data have yet to be developed. Further research is needed to understand the functional effects of genetic variants in genes of blood coagulation proteins that are critical to the pathogenesis of arterial and venous thrombotic disorders. In this review genetic variants in selected genes of the haemo static system and their relevance for arterial and venous thrombosis will be discussed.

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Section: Platelet Glycoprotein Ia (Gpia)mentioning

confidence: 89%

Biomarkers for arterial and venous thrombotic disorders

Mannhalter

2014

Hamostaseologie

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“…The GPIa/GPIIa complex (integrin α 2 β 1 ) is a major platelet collagen receptor and plays a major role in platelet adhesion. There is increasing evidence that gene polymorphisms in C807T are closely associated with GPIa/GPIIa expression [16] . Two gene polymorphisms in GPIa 807 have been identified as C807T on exon 7 and found to be associated with the level of GPIa/GPIIa expression.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, variant polymorphisms exist in different races. In 2001, Shi et al [15] studied the C807T polymorphism of the platelet collagen receptor α 2 gene-coding sequence in a Chinese cohort and found that it was associated with arterial thrombosis : another research indicated that the polymorphism also associated with unstable angina pectoris using platelet function tests [16] . While, Croft et al [17] demonstrated that the GPIa C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction.…”

Section: Introductionmentioning

confidence: 99%

Glycoprotein Ia C807T: Polymorphisms and Their Association with Platelet Function in Patients with the Acute Coronary Syndrome

Zhang¹,

Jin²,

Shi

et al. 2015

Cardiology

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Objectives: In the current study, we explored the relationship between glycoprotein Ia (GPIa) C807T polymorphisms and platelet function, and the sensitivity to dual antiplatelet treatment after percutaneous coronary intervention. Materials and Methods: We conducted a case-control study in 220 patients diagnosed with acute coronary syndrome (ACS) and 220 healthy controls. The platelet GPIa C807T genotypes of patients and controls were determined, and platelet aggregation and plasma concentrations of α-granule membrane protein (GMP-140) were assessed following stimulation with arachidonic acid and adenosine diphosphate. Results: The frequency of the GPIa T allele was higher in the ACS group than in controls. In the ACS group, platelet aggregation was significantly higher in individuals with the T allele than in those with the C allele. Dual antiplatelet treatment reduced platelet aggregation in all three genotypes, and patients carrying the CC genotype were more sensitive to antiplatelet treatment than those with the T allele, particularly the ones with the TT genotype. There were no differences in plasma GMP-140 levels. Conclusions: The GPIa C807Tpolymorphism might be a risk factor for the development and relapse of ACS. The GP Ia T allele may help to identify a group of patients who need more aggressive antithrombotic treatment.

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“…The COX-1-unrelated causes include up-regulation of COX-2 pathway of thromboxan A2 production by platelets, monocytes, macrophages, and increased production of prostaglandin F2-like compounds by lipid peroxidation of arachidonic acid. The genetic factors include polymorphism of glycoprotein IIIa and glycoprotein Ia/IIa collagen receptor genes (26)(27)(28)(29)(30). More evidences about prognostic significance of gene polymorphism are required.…”

Section: Aspirinmentioning

confidence: 99%

Clinical consequences of aspirin and clopidogrel resistance: an overview

Mijajlović

Shulga²,

Bloch

et al. 2013

Acta Neurol Scand

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The aim of this review is to introduce the concept of personalized medicine in secondary stroke prevention with antiplatelet medication. In the last years, many studies have been conducted regarding aspirin resistance and genotyping of clopidogrel metabolism. A review of the currently published data on this issue emphasizes the importance of focusing on the individualizing approach in antiplatelet therapy to achieve maximal therapeutic beneficial effect. However, many authors suggest that, before new information from ongoing trials become available, good clinical practice should dictate the use of low dose of aspirin that was shown to be effective in the prevention of stroke and death in patients with ischemic cerebrovascular disease, because higher doses do not have significantly better efficacy than lower doses in secondary stroke prevention, but lower-dose aspirin is associated with less side effects. On the other hand, many factors are associated with clopidogrel resistance, and recent genetic studies showed that the CYP2C19*2 genotype (loss-of-function allele) is related to poor metabolism of clopidogrel, but larger studies are needed to definitively confirm or rule out the clinical significance of this genetic effect. The aim of personalized approach in secondary stroke prevention is to take the most appropriate medicine in the right dose in accordance with the clinical condition of the patient and associated risk factors.

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Functional Effect of Platelet Membrane Glycoprotein Ia Gene Polymorphism in the Pathogenesis of Unstable Angina Pectoris

Cited by 4 publications

References 29 publications

Biomarkers for arterial and venous thrombotic disorders

Biomarkers for arterial and venous thrombotic disorders

Glycoprotein Ia C807T: Polymorphisms and Their Association with Platelet Function in Patients with the Acute Coronary Syndrome

Clinical consequences of aspirin and clopidogrel resistance: an overview

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