Functional Magnetic Resonance Imaging of Macaque Monkeys Performing Visually Guided Saccade Tasks

Koyama, Minoru; Hasegawa, Isao; Osada, Takahiro; Adachi, Yusuke; Nakahara, Kiyoshi; Miyashita, Yasushi

doi:10.1016/s0896-6273(04)00047-9

Cited by 254 publications

(240 citation statements)

References 71 publications

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“…This finding is consistent with most electrophysiological studies of LIP and with the strong contralateral bias reported in an fMRI study (3,7,27,28; but see ref. 8).…”

Section: Discussionsupporting

confidence: 91%

Topographic organization of macaque area LIP

Patel

Shulman

Baker

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Despite several attempts to define retinotopic maps in the macaque lateral intraparietal area (LIP) using histological, electrophysiological, and neuroimaging methods, the degree to which this area is topographically organized remains controversial. We recorded blood oxygenation level-dependent signals with functional MRI from two macaques performing a difficult visual search task on stimuli presented at the fovea or in the periphery of the visual field. The results revealed the presence of a single topographic representation of the contralateral hemifield in the ventral subdivision of the LIP (LIPv) in both hemispheres of both monkeys. Also, a foveal representation was localized in rostral LIPv rather than in dorsal LIP (LIPd) as previous experiments had suggested. Finally, both LIPd and LIPv responded only to contralateral stimuli. In contrast, human studies have reported multiple topographic maps in intraparietal cortex and robust responses to ipsilateral stimuli. These blood oxygenation level-dependent functional MRI results provide clear evidence for the topographic organization of macaque LIP that complements the results of previous electrophysiology studies, and also reveal some unexpected characteristics of this organization that have eluded these previous studies. The results also delineate organizational differences between LIPv and LIPd, providing support for these two histologically defined areas may subserve different visuospatial functions. Finally, these findings point to potential evolutionary differences in functional organization with human posterior parietal cortex.T he macaque lateral intraparietal area (LIP) has been the subject of many investigations over the past few decades. Anatomical studies of this area, which lies on the lateral bank of the intraparietal sulcus (IPS), have demonstrated widespread connectivity with a variety of cortical areas (1-3). Electrophysiological recordings in awake behaving macaques indicate that these connections underlie LIP's role in a range of functions ranging from the planning of saccades to the allocation of attention to the valuation of sensory information (4-6).Despite the many studies of its functional and anatomical properties, the topographic organization of LIP remains controversial. Two electrophysiology studies have reported that LIP has a strong contralateral bias and may be retinotopically organized (3, 7). However, the maps in these studies were coarse and not consistent with one another. In contrast, another study found neither a retinotopic map nor a contralateral-hemifield bias (8). Electrical stimulation studies of LIP have also resulted in an unusual result: in both studies, the sites representing the horizontal meridian lie rostral to those representing both the lower and upper visual fields (9, 10). Thus, the issue of topography in LIP remains an open question.Architectonic studies have divided LIP into dorsal and ventral divisions, but the functional significance of this difference is unclear (3, 11). Although cells throughout LIP appe...

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“…This finding is consistent with most electrophysiological studies of LIP and with the strong contralateral bias reported in an fMRI study (3,7,27,28; but see ref. 8).…”

Section: Discussionsupporting

confidence: 91%

Topographic organization of macaque area LIP

Patel

Shulman

Baker

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…A newly discovered map was found in the inferior frontal sulcus, just anterior to the precentral sulcus (highlighted with a white bounding box). Another map was found in superior precentral sulcus (sup-PCS); this location corresponds to the FEF, an area involved in eye movements and visual attention (Paus, 1996;Corbetta et al, 1998;Beauchamp et al, 2001;Koyama et al, 2004). Note that the more anterior and inferior prefrontal foci active during the 2-back face identity task do not appear to contain spatial maps.…”

Section: Resultsmentioning

confidence: 97%

Spatial maps in frontal and prefrontal cortex

2006

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“…Of particular interest is a neuroimaging experiment [20] that used the same saccade paradigm both in humans and macaque monkeys, namely the species in which area LIP has been defined physiologically. The results suggested a functional correspondence between the dorsal subdivision of area LIP in the monkey with the posterior IPS region in the human brain [20].…”

Section: Discussionmentioning

confidence: 99%

Morphological patterns of the intraparietal sulcus and the anterior intermediate parietal sulcus of Jensen in the human brain

Zlatkina

Petrides

2014

Proc. R. Soc. B.

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Distinct parts of the intraparietal sulcal cortex contribute to sensorimotor integration and visual spatial attentional processing. A detailed examination of the morphological relations of the different segments of the complex intraparietal sulcal region in the human brain in standard stereotaxic space, which is a prerequisite for detailed structure-to-function studies, is not available. This study examined the intraparietal sulcus (IPS) and the related sulcus of Jensen in magnetic resonance imaging brain volumes registered in the Montreal Neurological Institute stereotaxic space. It was demonstrated that the IPS is divided into two branches: the anterior ramus and the posterior ramus of the IPS, often separated by a submerged gyral passage. The sulcus of Jensen emerges between the anterior and posterior rami of the IPS, and its ventral end is positioned between the first and second caudal branches of the superior temporal sulcus. In a small number of brains, the sulcus of Jensen may merge superficially with the first caudal branch of the superior temporal sulcus. The above morphological findings are discussed in relation to previously reported functional neuroimaging findings and provide the basis for future exploration of structure-to-function relations in the posterior parietal region of individual subjects.

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Functional Magnetic Resonance Imaging of Macaque Monkeys Performing Visually Guided Saccade Tasks

Cited by 254 publications

References 71 publications

Topographic organization of macaque area LIP

Topographic organization of macaque area LIP

Spatial maps in frontal and prefrontal cortex

Morphological patterns of the intraparietal sulcus and the anterior intermediate parietal sulcus of Jensen in the human brain

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