2004
DOI: 10.1016/j.ceca.2003.11.005
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Functional separation of deep cytoplasmic calcium from subplasmalemmal space calcium in cultured human uterine smooth muscle cells

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Cited by 6 publications
(7 citation statements)
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“…Thus, mK44 trafficking could not occur in response to a Ca 2+ rise in subplasmalemmal space. However, Young and Zhang demonstrated a deep cytosolic Ca 2+ pool in hMSMCs, and that maxi‐K channel activity is regulated by Ca 2+ derived from this pool (Young & Zhang, 2004). It is possible that ER‐localized mK44 channels are sensitive to rises in cytosolic Ca 2+ and respond by the trafficking and reconstitution of functional channels.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, mK44 trafficking could not occur in response to a Ca 2+ rise in subplasmalemmal space. However, Young and Zhang demonstrated a deep cytosolic Ca 2+ pool in hMSMCs, and that maxi‐K channel activity is regulated by Ca 2+ derived from this pool (Young & Zhang, 2004). It is possible that ER‐localized mK44 channels are sensitive to rises in cytosolic Ca 2+ and respond by the trafficking and reconstitution of functional channels.…”
Section: Discussionmentioning
confidence: 99%
“…46,47 An additional, more complex route for Ca 2+ removal called vectorial Ca 2+ efflux, originally described in vascular smooth muscle, 48 has been found in rat 47 and human myometrium. 49,50 The complex spatiotemporal relationship between Ca 2+ entry and removal may account for the long-lasting [Ca 2+ ] i gradients in the myometrial cell during hormonal stimulation and prolonged membrane depolarization (FIG. 4).…”
Section: Ca 2+ Sources and Sinks During Uterine Contractionmentioning
confidence: 99%
“…Elementary events can also be due to calcium entry from the extracellular medium: in neurons, exocytotic release of synaptic vesicles is controlled by subplasmamembrane calcium microdomains triggered by the opening of voltage operated channels (VOCs) [7,8]; calcium microdomains with a subplasmalemmal localization are detectable in *Address correspondence to this author at the Department of Animal and Human Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, Italy; Tel: +39.011.6704667; Fax: +39.011.6704508; E-mail: luca.munaron@unito.it stimulated and unstimulated smooth muscle cells [9,10]. In endothelial cells (ECs), channels associated with the caveolae give rise to rather inhomogeneous high calcium levels along the subplasmamembrane cytoplasmic ring that selectively regulates nitric oxide (NO) release [11,12].…”
Section: Introductionmentioning
confidence: 99%