Functional Studies of Anodic Oxidized β-Ti-28Nb-11Ta-8Zr Alloy for Mechanical, In-vitro and Antibacterial Capability

Abstract

We developed an osseocompatible β-type Ti-28Nb-11Ta-8Zr (TNTZ) alloy that displays the excellent elastic modulus, cellular response, corrosion resistance and antibacterial capability demanded for bone-mimetic materials. The TNTZ alloy exhibited an elastic modulus of 49 GPa, which approximates that of human bones and prevent stress shielding effects. A further anodic oxidation and subsequent post-annealing modification formed a crystalline nanoporous TNTZ oxide layer (NPTNTZO(c)) on the alloy surface, potentially promoting interlocking with the extracellular matrix of bone cells and cell proliferation. Osteoblast viability tests also verified that NPTNTZO(c) enhanced cell growth more significantly than that of flat TNTZ. In addition, potentiodynamic polarization tests in Hanks’ balanced salt solution (HBSS) revealed that both TNTZ and NPTNTZO(c) exhibited better corrosion resistance than commercial pure titanium. Finally, NPTNTZO(c) reinforced with silver nanoparticles (NPTNTZO(c)/AgNPs) intensified the antibacterial efficiency against Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli for 8 h with antibacterial efficiencies of 87.82%, 97.68%, and 93.90%, respectively, facilitating infection prevention during surgery and recovery stages.

Current Advances and Applications of Tantalum Element in Infected Bone Defects

“…The oxide layer promotes the proliferation and growth of osteoblasts. Moreover, adding silver nanoparticles (Ag-NPs) to modify the oxide layer could produce inhibitory efficiencies of 87.82%, 97.68%, and 93.90% on P. aeruginosa , S. aureus , and E. coli , respectively (Figure B) . To further enhance the antibacterial activity of the polyetheretherketone (PEEK)–nano-Ta 2 O 5 composite scaffold, the composite was sulfonated using concentrated sulfuric acid, resulting in the hierarchical micro- and nanoporous structures.…”

“…The antibacterial functionalization of Ta-containing composite scaffolds is mainly located in Ta-containing alloys 61,62 and Ta-containing hybrid implants. 63,64 For alloys, the construction of surficial films is an easy way to achieve the antibacterial target.…”

“…61 The improved β-type Ti 28 Nb 11 Ta 8 Zr alloy possessed an elastic modulus (49 GPa) similar to that of human bone tissue. 62 To fully utilize this alloy, a porous nano-oxide layer was prepared on the Ti 28 Nb 11 Ta 8 Zr alloy surface by anodizing and postannealing the sample. The oxide layer promotes the proliferation and growth of osteoblasts.…”

“…The antibacterial functionalization of Ta-containing composite scaffolds is mainly located in Ta-containing alloys , and Ta-containing hybrid implants. , For alloys, the construction of surficial films is an easy way to achieve the antibacterial target. When magnetron sputtering technology was used to dope Cu into Ti 23 Nb 0.7 Ta 2 Zr (TNTZ) alloys to fabricate TNTZ–Cu films with different Cu contents, the antibacterial effect of the film was related to the Cu content, and the best antibacterial activity was observed when the atomic percentage of Cu was 8.3% (Figure A) .…”

Osseointegrating and phase-oriented micro-arc-oxidized titanium dioxide bone implants

“…2 Certain essential criteria must be satisfied before an implant can be classified as an osseointegrated implant: it must have a supporting base of an appropriate material, a biomimetic porous structure, and a bioactive contact interface. Supporting base materials are initially chosen for their mechanical properties, which should be similar to those of human bone; widely used materials include stainless steel, 3,4 commercial pure Ta, 5 Ti6Al4V, 6,7 TiNbTaZr (TNTZ), 8–10 and commercially available pure Ti (cp-Ti). 5,11–13 The architecture of the implant is then designed based on the intended application.…”