Functional subdivisions of the olfactory system correlate with lectin-binding properties inXenopus

Hofmann, Michaël; Meyer, Dietrich

doi:10.1016/0006-8993(91)91475-g

Cited by 76 publications

(54 citation statements)

References 16 publications

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“…Although the functional significance of the vomeronasal epithelium in amphibians remains unclear, these previous studies strongly suggest the presence of three types of distinct olfactory subsystems in the Xenopus primary olfactory system. Several authors reported differential stainings of one lectin, SBA, among the three kinds of the neuroepithelia and the axons emerging from each of them, and suggested the presence of three olfactory pathways in the Xenopus primary olfactory system [12,17,19,21,22]. This suggestion represents that each of the three distinct olfactory subsystems constitutes the unique projection pathway from the epithelium to the olfactory bulb, and that each olfactory pathway differs in its expression of glycoconjugates.…”

Section: Discussionmentioning

confidence: 99%

“…Key and Giorgi [19] applied lectinhistochemistry using soybean agglutinin (SBA), and reported the SBA-positive subset in the Xenopus main olfactory system. Thereafter, it has been suggested that the SBApositive subset arises from the MC and terminates in the ventral region of the MOB, and its function may differ from the SBA-negative subset arising from the PC [12,17,19,21,22]. These previous studies strongly suggest the presence of three distinct olfactory pathways in Xenopus laevis, although there are almost no morphological data on the differences in chemical properties among these three olfactory pathways.…”

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confidence: 99%

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Expression Patterns of Glycoconjugates in the Three Distinctive Olfactory Pathways of the Clawed Frog, Xenopus laevis.

Saito

Taniguchi

2000

The Journal of Veterinary Medical Science

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Expression Patterns of Glycoconjugates in the Three Distinctive Olfactory Pathways of the Clawed Frog, Xenopus laevis.

Saito

Taniguchi

2000

The Journal of Veterinary Medical Science

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“…These three chambers possessed different types of sensory epithelia separated from one another by a non-sensory respiratory epithelium. The principal chamber was lined with the OE, the middle chamber the middle chamber epithelium (MCE) [9,17,50], and the inferior chamber the VNE. The MCE is characteristic of Xenopus laevis as the sensory epithelium.…”

Section: Olfactory System In Xenopus Laevismentioning

confidence: 99%

Phylogenic Aspects of the Amphibian Dual Olfactory System

Taniguchi

Saito

Oikawa³

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. The phylogenic significance of the subdivision of dual olfactory system is reviewed mainly on the basis of our findings by electron microscopy and lectin histochemistry in the three amphibian species. The dual olfactory system is present in common in these species and consists of the projection from the olfactory epithelium (OE) to the main olfactory bulb (MOB) and that from the vomeronasal epithelium (VNE) to the accessory olfactory bulb (AOB). The phylogenic significance of subdivisions in the dual olfactory system in the amphibian must differently be interpreted. The subdivision of the MOB into its dorsal region (D-MOB) and ventral region (V-MOB) in Xenopus laevis must be attributed to the primitive features in their olfactory receptors. The middle cavity epithelium lining the middle cavity of this frog possesses both ciliated sensory cells and microvillous sensory cells, reminding the OE in fish. The subdivision of the AOB into the rostral (R-AOB) and caudal part (C-AOB) in Bufo japonicus formosus must be regarded as an advanced characteristic. The lack of subdivisions in both MOB and AOB in Cynops pyrrhogaster may reflect their phylogenic primitiveness. Since our lectin histochemistry to detect glycoconjugates expressed in the olfactory pathway reveals the subdivisions in the dual olfactory system in the amphibian, the glycoconjugates may deeply participate in the organization and function of olfactory pathways in phylogeny. KEY WORDS: amphibians, electron microscopy, lectin histochemistry, main olfactory system, vomeronasal system.There are increasing data about the olfactory system in vertebrates. These data are minute, refined, and sometimes sophisticated and based mainly on molecular biology and/or genetic engineering. On the other hand, studies on the phylogeny of the olfactory system on the basis of morphology and comparative anatomy are rather neglected at present. However, we believe that the nature of the olfactory system must be elucidated from both molecular and morphological point of views closely connected with each other. In the present review, therefore, we dare to try to give our morphological data to examine the phylogeny of the olfactory system in amphibians. Because of the limitation of printed pages, our present review must be restricted to amphibians. APPEARANCE OF THE DUAL OLFACTORY SYSTEMOlfaction is one of special senses of vertebrates and appears earliest among special senses in phylogeny. In the fish, the primary olfactory system consists of the olfactory epithelium (OE) as the receptor and the olfactory bulb as the primary olfactory center, i.e., the OE lining the nasal sac projects axons to the olfactory bulb [4,18,31,61,72]. There are no morphological subdivisions in the fish olfactory system. In the amphibian, however, the receptor is subdivided into the OE and the vomeronasal epithelium (VNE), and the primary center into the main (MOB) and the accessory olfactory bulb (AOB). These subdivisions lead to the dual olfactory system, main olfactory and vomeronasal system ...

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“…However, independent of methodological differences, reasonable numbers of SBA binding neurones have been demonstrated in the mammalian brain. In contrast to the situation in mammals, SBA labels the surface of only a (sub)population of olfactory neurones in eels (Franceschini and Ciani, 1991) and frogs (Hofmann and Meyer, 1991;Key and Giorgi, 1986), but does not label other cells in the central nervous system of these animals. In mice it has been shown that viciu uillosa agglutinin, which labels essentially the same cells as SBA (Kosaka and Heizmann, 19891, fails to produce the typical labelling pattern in 1 week old animals (Nakagawa et al, 1987).…”

Section: Discussionmentioning

confidence: 85%

“…The differential distribution of glycoconjugates in tissues and cell types as well as during differentiation and development (Damjanov, 1987;Hofmann and Meyer, 1991;Holthiifer and Virtanen, 1987;Pfenninger and Maylie-Pfenninger, 1981) indicates that glycoconjugates are of some functional importance. Glycoconjugates are probably involved in cell-cell interactions.…”

Section: Introductionmentioning

confidence: 99%

The distribution of N-acetylgalactosamine in the cochlear nucleus of the gerbil revealed by lectin binding with soybean agglutinin

Gleich

1994

Hearing Research

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A horseradish peroxidase conjugated lectin from Glycine max (soy bean agglutinin; SBA) was used to characterise the distribution of N-acetylgalactosamine in the cochlear nucleus of the mongolian gerbil. SBA bound differentially to a variety of structures within the cochlear nucleus. Specific SBA labelling was associated with large non-granule neurones of variable size and shape throughout the cochlear nucleus. Compared to adjacent Nissl-stained sections 80% of the non-granule cells in the dorsal cochlear nucleus (DCN) and more than 90% of the non-granule cells in the ventral cochlear nucleus (VCN) bound SBA. The variation in location, size and shape as well as the high percentage of the labelled neurones suggest that cells of several, if not all, non-granule cell types, which have been described for the cochlear nucleus according to the usual Nissl schemes, are SBA positive. Granule cells did not bind SBA because all SBA-labelled cells had diameters above 10 pm. Diffuse labelling, not systematically associated with cells or fibres, was high in the molecular and fusiform cell layers of the DCN and that part of the granule cell area located close to the surface of the VCN. Darkly labelled granules (up to 2 pm diameter) were prominent in the area of the VIIIth nerve root. After long SBA incubations, they were also present in VCN and to a lesser degree in DCN. The results are discussed with respect to findings in other brain areas and the possible co-localisation of gamma aminobutyric acid (GABA), parvalbumin and N-acetylgalactosamine.

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Functional subdivisions of the olfactory system correlate with lectin-binding properties inXenopus

Cited by 76 publications

References 16 publications

Expression Patterns of Glycoconjugates in the Three Distinctive Olfactory Pathways of the Clawed Frog, Xenopus laevis.

Expression Patterns of Glycoconjugates in the Three Distinctive Olfactory Pathways of the Clawed Frog, Xenopus laevis.

Phylogenic Aspects of the Amphibian Dual Olfactory System

The distribution of N-acetylgalactosamine in the cochlear nucleus of the gerbil revealed by lectin binding with soybean agglutinin

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