Functional Variant of Manganese Superoxide Dismutase (<i>SOD2 V16A</i>) Polymorphism Is Associated with Prostate Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Study

Kang, Daehee; Lee, Eunil; Park, Sue Kyung; Berndt, Sonja I.; Peters, Ulrike; Reding, Douglas J.; Chatterjee, Nilanjan; Welch, Robert W.; Chanock, Stephen J.; Huang, Wen‐Yi; Hayes, Richard B.

doi:10.1158/1055-9965.epi-07-0160

Cited by 125 publications

(105 citation statements)

References 30 publications

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“…The frequency distributions of C and T alleles were found to be respec- has the similar CC genotype frequency as seen in AfricanAmerican [35], Finn [36], and Italian populations [37]. We detected considerably lower CC genotype frequency than those found in Korean [38], Japan [39], Chinese [40] and Taiwan [41] populations and higher frequencies than those found in American [23], Polish [42], Danish [43], German [44] and Russian [45] populations. Eventually, CC genotype frequency in populations of the eastern countries, were lower (between 0-17%) found than the western countries (between 42-67%) ( Table 4).…”

Section: Resultssupporting

confidence: 75%

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Manganese-Superoxide Dismutase (MnSOD) Polymorphisms

Siliğ

Taş²,

Pınarbaşı³

2015

Turk J Bioch

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Objective: Manganese superoxide dismutase (MnSOD,SOD2), the only known superoxide scavenger in mitochondria, may be particularly important for antioxidant defense because mitochondria are the major sites for cellular metabolism and hence production of reactive oxygen species. Methods: In this study, 440 Turkish individuals were genotyped for polymorphisms of SOD2 gene. The distribution of these polymorphisms in this population was examined using a PCR-RFLP method. Results: In the present study, a total of 440(females: 201, 46% and males: 239, 54%) healthy individuals were studied. The mean age of the study population was 54,41±5,76 years (males, 55,34±5,76; females, 53,12±7,16 and males: 239, 54%) unrelated healthy volunteers from central Anatolia. There was no age and sex restriction for selection of the healthy volunteers, who were free of any chronic diseases, living in the same geographic area, and having no history of any cancer. We attempted to include all the control studies published to data on the SOD2 rs4880 polymorphism. DNA isolationTwo milliliters peripheral blood samples were collected in to citrate containing tubes from all subjects. DNA was extracted from whole blood by salting out procedure as soon as the samples reached to laboratory [19]. GenotypingThe distribution of these polymorphisms was examined using a PCR-RFLP method. For amplifying the SOD2 rs4880 polymorphism, forward primer 5'-ACC AGC AGG CAG CTG GCG CCG G-3' and reverse primer 5'-GCG TTG ATG TGA GGT TCC AC-3'were used. PCR reactions contained 0,75 µL (25 pmol/µL) of each primer, 2µL dNTPs (1mmol/L), 1,5µL of 25 mmol/L MgCI2, 1.5 Units of Taq DNA polymerase and 16,2µL sterile deionized water. DNA 50-100 ng is in a total volume of 50 µL. The Statistical analysisAll statistical analyses were performed using the Statistical Package for Social Sciences Program (SPSS, version 11). The Chi-square (X 2 ) test was used to evaluate the association between healthy individuals and SOD genotypes. Genotype, allele frequencies was estimated by counting. Hardy-Weinberg equilibrium between expected and observed genotype distributions was assessed using the X

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Section: Resultssupporting

confidence: 75%

“…SOD2 is a mitochondrial enzyme that catalyzes the formation of H 2 O 2 from superoxide radicals. The variant allele of SOD2 has been associated with elevated risk of breast [22], prostate [23], lung [24] and ovarian [25] cancers and non-Hodgkin's lymphoma [26].…”

Section: Discussionmentioning

confidence: 99%

Manganese-Superoxide Dismutase (MnSOD) Polymorphisms

Siliğ

Taş²,

Pınarbaşı³

2015

Turk J Bioch

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“…Briefly, of the 22 studies (Wang et al, 2001;Woodson et al, 2001;Lin et al, 2003;Liu et al, 2004;Wang et al, 2004;Li et al, 2005;Taufer et al, 2005;Ho et al, 2006;Choi et al, 2007;di Martino et al, 2007;Ergen et al, 2007;Kang et al, 2007;Arsova-Sarafinovska et al, 2008;Iguchi et al, 2008;Mikhak et al, 2008;Bica et al, 2009;Cheng et al, 2009;Iguchi et al, 2009;Sun et al, 2009;Zejnilovic etal., 2009), the sample size ranged between 100 and 3,030, and there were twelve studies on prostate cancer, four studies on esophageal cancer, and six studies on lung cancer. All studies, except for five of them (Taufer et al, 2005;Bica et al, 2009;Sun et al, 2009;Zejnilovic et al, 2009), indicated that the distribution of genotypes in the controls was consistent with HardyWeinberg equilibrium, while only one study conducted by Lin et al (2003) contained no data for Hardy-Weinberg equilibrium.…”

Section: Study Characteristicsmentioning

confidence: 99%

Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects

Sun

Wang²,

Lu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Altered expression or function of manganese superoxide dismutase (MnSOD) has been shown to be associated with cancer risk but assessment of gene polymorphisms has resulted in inconclusive data. Here a search of published data was made and 22 studies were recruited, covering 20,025 case and control subjects, for metaanalyses of the association of MnSOD polymorphisms with the risk of prostate, esophageal, and lung cancers. The data on 12 studies of prostate cancer (including 4,182 cases and 6,885 controls) showed a statistically significant association with the risk of development in co-dominant models and dominant models, but not in the recessive model. Subgroup analysis showed there was no statistically significant association of MnSOD polymorphisms with aggressive or nonaggressive prostate cancer in different genetic models. In addition, the data on four studies of esophageal cancer containing 620 cases and 909 controls showed a statistically significant association between MnSOD polymorphisms and risk in all comparison models. In contrast, the data on six studies of lung cancer with 3,375 cases and 4,050 controls showed that MnSOD polymorphisms were significantly associated with the decreased risk of lung cancer in the homozygote and dominant models, but not the heterozygote model. A subgroup analysis of the combination of MnSOD polymorphisms with tobacco smokers did not show any significant association with lung cancer risk, histological type, or clinical stage of lung cancer. The data from the current study indicated that the Ala allele MnSOD polymorphism is associated with increased risk of prostate and esophageal cancers, but with decreased risk of lung cancer. The underlying molecular mechanisms warrant further investigation.

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“…Associations between six single-nucleotide polymorphisms (SNPs) of the earlier-mentioned five genes and CRC have been reported in different ethnic groups (Smith et al, 2001;Landi et al, 2003Landi et al, , 2005Krzesniak et al, 2004;Jiang et al, 2005;McGreavey et al, 2005;Murtaugh et al, 2005;Slattery et al, 2005Slattery et al, , 2006Berndt et al, 2006;Huang et al, 2006;Koh et al, 2006;Kuriki et al, 2006;Matsuo et al, 2006;Moreno et al, 2006;Theodoropoulos et al, 2006;Tranah et al, 2006;Hansen et al, 2007;Kang et al, 2007;Stern et al, 2007;Vogel et al, 2007;Yin et al, 2007;Kury et al, 2008;Funke et al, 2009;Khatami et al, 2009;Tsilidis et al, 2009;Yang et al, 2009;Engin et al, 2010;Meplan et al, 2010;Loh et al, 2011;Wu et al, 2011;Crous-Bou et al, 2012;Gil et al, 2012). These six variants comprised rs12917 and rs2308321 of MGMT, rs1229984 of ADH1B, rs4880 of SOD2, rs2228001 of XPC, and rs1801282 of PPARG.…”

Section: Introductionmentioning

confidence: 99%

Association Between Six Genetic Polymorphisms and Colorectal Cancer: A Meta-Analysis

Chen

Wang

Liao

et al. 2014

Genetic Testing and Molecular Biomarkers

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Objective: The aim of this study was to determine whether six genetic polymorphisms confer susceptibility to colorectal cancer (CRC). Methods: A systematic search for candidate genes of CRC was performed among several online databases, including PubMed, Embase, Web of Science, the Cochrane Library, CNKI, and Wanfang online libraries. After a comprehensive filtering procedure, we harvested five genes, including MGMT (rs12917 and rs2308321), ADH1B (rs1229984), SOD2 (rs4880), XPC (rs2228001), and PPARG (rs1801282). Using the REVMAN and Stata software, six meta-analyses were conducted for associations between CRC and the just-mentioned genetic variants. Results: A total of 34 comparative studies among 17,289 cases and 54,927 controls were involved in our meta-analyses. Significant association was found between ADH1B rs1229984 polymorphism and CRC ( p = 0.03, odds ratio [OR] = 1.18, 95% confidence interval [CI] = 1.01-1.36). We also found significant association between PPARG rs1801282 polymorphism and CRC ( p = 0.004, OR = 1.498, 95% CI = 1.139-1.970), and this significant association is specific in Caucasians ( p = 0.004, OR = 1.603, 95% CI = 1.165-2.205). Conclusions: The current meta-analysis has established that ADH1B (rs1229984) and PPARG (rs1801282) are two risk variants of CRC.

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Functional Variant of Manganese Superoxide Dismutase (SOD2 V16A) Polymorphism Is Associated with Prostate Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Study

Cited by 125 publications

References 30 publications

Manganese-Superoxide Dismutase (MnSOD) Polymorphisms

Manganese-Superoxide Dismutase (MnSOD) Polymorphisms

Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects

Association Between Six Genetic Polymorphisms and Colorectal Cancer: A Meta-Analysis

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