Functionalisation of tetraalkylsilanes derived from CH activation; towards annulations of diterpenoids

Catalytic C−H/Olefin Coupling

“…68 In addition, Weber extended this coupling reaction to polymer synthesis 69 and Woodgate reported on the use of these types of coupling reaction in the synthesis of a natural product. 70 A reference book summarizing the fundamental aspects and recent advances in this field has recently been published, 71 suggesting the presence of a new realm awaiting further development.…”

“…We investigated the practical scale (10−30 g of the starting ketone) synthesis of an ortho-alkylated aromatic ketone. , Sharpless reported that some of the reactions can be carried out in the absence of solvents and Woodgate reported on the use of these types of coupling reaction in the synthesis of a natural product …”

Ru3(CO)12-Catalyzed Silylation of Benzylic C−H Bonds in Arylpyridines and Arylpyrazoles with Hydrosilanes via C−H Bond Cleavage

“…The catalytic functionalization of C−H bonds is a highly valuable methodology in organic synthesis because no functional groups are sacrificed using this protocol . To date, several catalytic reactions, such as C−H/olefin, , C−H/acetylene, C−H/CO/olefin, C−H/ArB(OR) 2 , C−H/Ar 4 Sn, C−H/HSiR 3 , − and C−H/HB(OR) 2 couplings, have been developed. In almost all cases, sp 2 C−H bonds, i.e., aromatic and olefinic C−H bonds, are involved.…”

Catalytic Addition of C – H Bonds to C – C Multiple Bonds

“…Equation 10 Scheme 8 Two distinct reaction pathways for reactions of acyclic enones with olefins This catalytic alkylation of C -H bonds in aromatic ketones has been used for functionalization of diterpenoid [42][43][44]. In this case, Ru(CO) 2 (PPh 3 ) 3 showed higher catalytic activity than RuH 2 (CO)(PPh 3 ) 3 .…”