Functionalized boron-dipyrromethenes and their applications

Lakshmi, Vellanki; Sharma, Ritambhara; Ravikanth, Mangalampalli

doi:10.2147/roc.s60504

Cited by 21 publications

(12 citation statements)

References 113 publications

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“…Being a photostable substitute for fluorescein, it is strongly absorbing and emits relatively sharp fluorescence maxima in the visible and near infrared region with high quantum yields up to ΦF = 0.97. 22,23,24 Due to its relative insensitivity to the pH, solvent and polarity of its environment it makes a preferred choice for the labelling of biomolecules. 25 Structural modifications of these dyes allow the tuning of their fluorescence characteristics as well as easy labelling to various biomolecules.…”

Section: Fluorescent Tagsmentioning

confidence: 99%

Development and Characterization of Fluorescent Mannose and Sialic Acid Based Chemical Probes for Lectin Discovery and Enzyme Studies

Abukar¹

2023

Preprint

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BODIPY (4,4–Difluoro-4-boro-3a,4a-diaza-s-indacene) dyes are relatively nonpolar fluorescent molecules used as biological labeling reagents. The advantages of using BODIPY dyes as tags include their unique photochemical properties, allowing for an easy and sensitive monitoring of target components. This thesis will discuss the synthesis of novel fluorescent “BODIPY”-labeled carbohydrate-based chemical probes and highlight their uses in different biological applications. In chapter one, we have focused on the development of BODIPY-mannose-based chemical probes for the discovery and characterization of mannose-binding lectins on surfaces of Actinobacteria. The synthesis of these probes and their efficiency to detect mannose-binding lectins using different techniques such as Fluorescence microscopy and flow cytometry are discussed. In chapter two, we have focused on the chemo-enzymatic synthesis of BODIPY-sialic acid based chemical probes for enzymatic detection of specific glycoconjugates on proteins. The use of these probes as donor substrates to probe the enzymes involved in glycan sialylation are discussed

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Section: Fluorescent Tagsmentioning

confidence: 99%

Development and Characterization of Fluorescent Mannose and Sialic Acid Based Chemical Probes for Lectin Discovery and Enzyme Studies

Abukar¹

2023

Preprint

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“…Excess copper and iron in the body cause cell toxicity, cancer and several neurodegenerative diseases, including Alzheimer's, Parkinson's, Menkes and Wilson. Thus, in recent years, there has been interesting research in the field of the development of colorimetric and/or fluorimetric chemical sensors suitable for the quick and simple detection of important cations for the biological and environmental media [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of a meso-Anthracene-BODIPY Derivative for Colorimetric Recognition of Cu2+ and Fe3+

Pinto

Gonçalves

Costa

et al. 2020

The 24th International Electronic Conference on Synthetic Organic Chemistry

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Ions exist widely in biological and environmental media, and the scarcity or excess of these species can have adverse consequences. BODIPY dyes appear as heterocyclic organic compounds capable of recognizing metal ions in solution and in cells, through optical signals (colorimetric and/or fluorimetric), and their photophysical properties can be adjusted through the functionalization of the BODIPY core. In continuation of the work developed recently, our research group reports the synthesis of a meso-anthracene-BODIPY derivative and the respective characterization by 1 H and 13 C nuclear magnetic resonance (NMR) and UV-Vis absorption spectroscopies. The preliminary study of the chemosensory capacity of the BODIPY derivative was also carried out in the presence of several cations in acetonitrile solution which shows a selective colorimetric response for Cu 2+ and Fe 3+ .

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“…Understanding the photophysical properties of these systems (Lu et al, 2014) is of principal importance, not only because of the intrinsic potential applications but, also in the design of new dyes with specific properties. The main synthetic advantage of BODIPY dye is that, the unique structure of dye skeleton provides eight positions which can be easily functionalized to fine-tune their electronic properties (Lakshmi et al, 2015(Lakshmi et al, , 2016. There are excellent reviews available on the BODIPYs based on the different applications, such as: fluorescent NIR probes (Yuan et al, 2013), sensitizers for PDT (Kamkaew et al, 2013), organic materials for photovoltaics (Bessette and Hanan, 2014), D-A type systems with focus on energy/electron transfer (Loudet and Burgess, 2007), fluorescent sensors (Boens et al, 2012;Ni and Wu, 2014), BODIPY based multichromophore cassettes (Ziessel et al, 2007), etc.…”

Section: Introductionmentioning

confidence: 99%

Carbazole Substituted BODIPYs

Gupta¹,

Kesavan²

2019

Front. Chem.

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Difluoroboron-dipyrromethenes (BODIPYs) are highly popular fluorescent dyes with applications as NIR probes for bioimaging, fluorescent tags/sensors and as photosensitizers in cancer therapy and organic photovoltaics. This review concentrates on the synthesis and spectral properties of BODIPY dyes conjugated with carbazole heterocycle. The carbazole is an electron rich tricyclic compound and due to its excellent electronic properties, it is extensively used in the production of electroluminescent materials and polymers. This review highlights the recent progress made on the series of BODIPY derivatives containing carbazole ring at alpha, beta, and meso-positions of the BODIPY skeleton. Carbazole based hybrid BODIPYs, carbazole linked aza-BODIPYs and carbazole-fused BODIPYs are also discussed.

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Functionalized boron-dipyrromethenes and their applications

Cited by 21 publications

References 113 publications

Development and Characterization of Fluorescent Mannose and Sialic Acid Based Chemical Probes for Lectin Discovery and Enzyme Studies

Development and Characterization of Fluorescent Mannose and Sialic Acid Based Chemical Probes for Lectin Discovery and Enzyme Studies

Synthesis and Characterization of a meso-Anthracene-BODIPY Derivative for Colorimetric Recognition of Cu2+ and Fe3+

Carbazole Substituted BODIPYs

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