Functionalized poly(pyrrole-3-carboxylic acid) nanoneedles for dual-imaging guided PDT/PTT combination therapy

Liu, Xin; Su, Hao; Shi, Wei; Yang, Liu; Sun, Yanan; Ge, Dongtao

doi:10.1016/j.biomaterials.2018.03.030

Cited by 92 publications

(55 citation statements)

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“…Given that singlet oxygen is characterized with a short half‐life less than 40 ns and confined diffusion range of 10–20 nm in biological system, efficient cellular internalization of photosensitizers to provide singlet oxygen with the accessibility to the cytoplasm and target organelles is fundamental to effective PDT. Therefore, the cellular internalization of T820/Ce6 micelles was investigated qualitatively and quantitatively in murine melanoma B16 cells.…”

Section: Resultsmentioning

confidence: 99%

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Tian

Jiang

et al. 2018

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triggered by near-infrared (NIR) lightexcited photothermal agents [10] while PDT causes the cell death by photosensitizers generating highly cytotoxic reactive oxygen species (ROS) upon light excitation. [11][12][13] With distinct mechanisms of action, the integration of PTT and PDT into one nanoplatform holds great potential to achieve highly efficient cancer therapy. [14][15][16] However, in such combined therapy, two different excitation wavelengths are usually required for the activation of PTT and PDT, [17][18][19] leading to complicated treatment process and prolonged therapeutic time. Thus, it is highly desirable to design a nanoplatform with single NIR light-induced phototherapy.Although strategies of single-wavelength NIR light-mediated PTT/PDT combination therapy have been reported, photothermal agents commonly used in combined systems are inorganic nanomaterials, like gold nanostructures, [20][21][22] MoS 2 nanosheets, [23] black phosphorus nanosheets, [24] and black titania, [25] which show tedious preparation process, poor degradation, difficult excretion, and potential long-term toxicity. NIR organic dyes, which possess unique advantages of outstanding biodegradability and biocompatibility in contrast with inorganic photothermal agents, will be ideal alternatives. Especially, for new indocyanine green (IR820), a structural analog of indocyanine green (ICG), which has been approved by the Food and Drug Administration (FDA) in clinical use, [26][27][28] holds the suitable fluorescence, strong absorption in NIR region, and efficient light-thermal conversion. [29,30] Additionally, it is more stable and easily modified due to the meso-halogen in its chemical structure. Unfortunately, it differs from organic photodynamic agents in intrinsic excitation wavelength, bringing a great challenge to achieve single NIR laser-induced combinational phototherapy. Moreover, it suffers from short half-life in blood, rapid clearance from the body, and lack of specificity to target tumor area. [31,32] Chlorin e6 (Ce6), an FDA-approved second-generation photosensitizer, [33] is extensively used in PDT on account of its high singlet oxygen generation efficiency, [34] near-infrared light excitation allowing deep tissue penetration, and fluorescence imaging capability. [35,36] Despite these upsides, Ce6 has shortcomings including poor water solubility and nonspecific accumulation in tumor sites, [37] which largely compromise Phototherapy as a promising cancer diagnostic and therapeutic strategy has aroused extensive attention. However, single-wavelength near-infrared (NIR) light-triggered combinational treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) is still a great challenge. Herein, a multifunctional micelle activated by a single-wavelength laser for simultaneous PTT and PDT as well as fluorescence imaging is developed. Briefly, new indocyanine green (IR820) is conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) via the linker 6-aminocaproic acid, and then, chlorin e6 (Ce6) is enc...

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Section: Resultsmentioning

confidence: 99%

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Tian

Jiang

et al. 2018

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“…The PPy nanoneedles were synthesized via aqueous dispersion polymerization as reported. 27 The TEM image ( Fig. 1A) of PPy nanoparticles clearly showed the needles-like morphology with a length of $40 nm and width of $5 nm.…”

Section: Synthesis Of Ppy-ha@doxmentioning

confidence: 96%

“…Interestingly, the PPy nanoneedles were investigated. 27,28 Beneting from their unique needle-like morphology, PPy nanoneedles were expected to penetrate tumors more rapidly, and deliver drugs into the organelles more effectively.…”

Section: Introductionmentioning

confidence: 99%

PPy nanoneedle based nanoplatform capable of overcoming biological barriers for synergistic chemo-photothermal therapy

et al. 2020

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“…Unlike routine chemotherapeutic drugs, Art kills tumour cell through the generation of ROS. Due to a short half-life and conned diffusion range of ROS, 45,46 the cellular uptake of carrier for Art should be very important to cancer treatment. To observe the cellular uptake of the nanoparticles, Rhodamine B (RhB) labeled FeOOH@PNE nanoparticles (FeOOH@PNE-RhB) were synthesized (Fig.…”

Section: Cellular Uptakementioning

confidence: 99%

Poly(norepinephrine)-coated FeOOH nanoparticles as carriers of artemisinin for cancer photothermal-chemical combination therapy

Shen

Shi

et al. 2019

RSC Adv.

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Functionalized poly(pyrrole-3-carboxylic acid) nanoneedles for dual-imaging guided PDT/PTT combination therapy

Cited by 92 publications

References 50 publications

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

PPy nanoneedle based nanoplatform capable of overcoming biological barriers for synergistic chemo-photothermal therapy

Poly(norepinephrine)-coated FeOOH nanoparticles as carriers of artemisinin for cancer photothermal-chemical combination therapy

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