Functionalized prosthetic interfaces using 3D printing: Generating infection-neutralizing prosthesis in dentistry

Nagrath, Malvika; Sikora, Alexander; Graca, Jacob; Chinnici, Jennifer; Rahman, Saeed Ur; Reddy, Sharaschandra G.; Ponnusamy, Sasikumar; Maddi, Abhiram; Arany, Praveen R.

doi:10.1016/j.mtcomm.2018.02.016

Cited by 31 publications

(22 citation statements)

References 17 publications

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“…XPS is a more advanced method for determining the elemental weight composition and oxidation states of the elements. Although most spectroscopic techniques are surface characterisation techniques, they are however, helpful in determining the presence of specific elements in the material, confirming the stability of materials after heat treatment during AM, compatibility of different material components and affirming the presence of functional materials in additively manufactured parts, such as antifungal properties in 3-D printed dentures [ 96 ].…”

Section: Discussionmentioning

confidence: 99%

“…While the flexural strength of the dentures were characterised by mechanical testing, FTIR spectroscopy was used to confirm the presence of the antifungal agent in the printed dentures. Obvious peaks at 1017 cm −1 in the spectra of the printed dentures correlated with the C-C-H groups of the antifungal groups [ 96 ].…”

Section: Spectroscopy and Its Application In Am Techniquesmentioning

confidence: 99%

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Application of Spectroscopy in Additive Manufacturing

2021

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Additive manufacturing (AM) is a rapidly expanding material production technique that brings new opportunities in various fields as it enables fast and low-cost prototyping as well as easy customisation. However, it is still hindered by raw material selection, processing defects and final product assessment/adjustment in pre-, in- and post-processing stages. Spectroscopic techniques offer suitable inspection, diagnosis and product trouble-shooting at each stage of AM processing. This review outlines the limitations in AM processes and the prospective role of spectroscopy in addressing these challenges. An overview on the principles and applications of AM techniques is presented, followed by the principles of spectroscopic techniques involved in AM and their applications in assessing additively manufactured parts.

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Section: Discussionmentioning

confidence: 99%

Section: Spectroscopy and Its Application In Am Techniquesmentioning

confidence: 99%

Application of Spectroscopy in Additive Manufacturing

2021

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“…Fahimipour F et al fabricated a vascular endothelial growth factor (VEGF)-loaded gelatin/alginate/β-TCP composite scaffold by 3D printing to promote craniofacial tissue engineering [ 93 ]. Our group recently demonstrated feasibility of this approach with small molecules in PLGA microspheres imparting anti-fungal characteristics to polymethylmethacrylate dental prosthesis ( Figure 6 ) [ 94 ]. These strategies are enabling simulation of both soluble and insoluble natural functions of the ECM.…”

Section: 3d Printingmentioning

confidence: 99%

Nanoscale and Macroscale Scaffolds with Controlled-Release Polymeric Systems for Dental Craniomaxillofacial Tissue Engineering

et al. 2018

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Tremendous progress in stem cell biology has resulted in a major current focus on effective modalities to promote directed cellular behavior for clinical therapy. The fundamental principles of tissue engineering are aimed at providing soluble and insoluble biological cues to promote these directed biological responses. Better understanding of extracellular matrix functions is ensuring optimal adhesive substrates to promote cell mobility and a suitable physical niche to direct stem cell responses. Further, appreciation of the roles of matrix constituents as morphogen cues, termed matrikines or matricryptins, are also now being directly exploited in biomaterial design. These insoluble topological cues can be presented at both micro- and nanoscales with specific fabrication techniques. Progress in development and molecular biology has described key roles for a range of biological molecules, such as proteins, lipids, and nucleic acids, to serve as morphogens promoting directed behavior in stem cells. Controlled-release systems involving encapsulation of bioactive agents within polymeric carriers are enabling utilization of soluble cues. Using our efforts at dental craniofacial tissue engineering, this narrative review focuses on outlining specific biomaterial fabrication techniques, such as electrospinning, gas foaming, and 3D printing used in combination with polymeric nano- or microspheres. These avenues are providing unprecedented therapeutic opportunities for precision bioengineering for regenerative applications.

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“…Since its approval from the Food and Drug Administration of the United States of America (FDA) for biomedical applications, the research interest in PCL has increased exponentially [ 19 ]. In this field, PCL has been reported for the preparation of biomedical devices for regenerative medicine [ 19 , 20 ], orthopedics [ 21 ], drug delivery systems [ 22 ], and dental applications such as rings for implants [ 23 ], scaffolds for cell proliferation [ 24 ], implant coatings [ 25 ], or as functionalized prosthesis interfaces [ 26 ]. Considering the freedom that AM provides through the possibility of customization of medical devices, the possible applications can increase in all areas, including dentistry.…”

Section: Introductionmentioning

confidence: 99%

Influence of Build Orientation, Geometry and Artificial Saliva Aging on the Mechanical Properties of 3D Printed Poly(ε-caprolactone)

Pinho

Piedade

2021

Materials

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Additive manufacturing of polymers has evolved from rapid prototyping to the production of functional components/parts with applications in distinct areas, ranging from health to aeronautics. The possibility of producing complex customized geometries with less environmental impact is one of the critical factors that leveraged the exponential growth of this processing technology. Among the several processing parameters that influence the properties of the parts, the geometry (shape factor) is amid less reported. Considering the geometric complexity of the mouth, including the uniqueness of each teething, this study can contribute to a better understanding of the performance of polymeric devices used in the oral environment for preventive, restorative, and regenerative therapies. Thus, this work aims to evaluate 3D printed poly(ε-caprolactone) mechanical properties with different build orientations and geometries. Longitudinal and transversal toolpaths produced specimens with parallelepiped and tubular geometry. Moreover, as it is intended to develop devices for dentistry, the influence of artificial saliva on mechanical properties was determined. The research concluded that the best mechanical properties are obtained for parallelepiped geometry with a longitudinal impression and that aging in artificial saliva negatively influences all the mechanical properties evaluated in this study.

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Functionalized prosthetic interfaces using 3D printing: Generating infection-neutralizing prosthesis in dentistry

Cited by 31 publications

References 17 publications

Application of Spectroscopy in Additive Manufacturing

Application of Spectroscopy in Additive Manufacturing

Nanoscale and Macroscale Scaffolds with Controlled-Release Polymeric Systems for Dental Craniomaxillofacial Tissue Engineering

Influence of Build Orientation, Geometry and Artificial Saliva Aging on the Mechanical Properties of 3D Printed Poly(ε-caprolactone)

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