Functionalized SnO2 nanobelt field-effect transistor sensors for label-free detection of cardiac troponin

Cheng, Yi; Chen, Kan Sheng; Meyer, Nancy; Yuan, Jing; Hirst, Linda S.; Chase, P. Bryant; Xiong, Peng

doi:10.1016/j.bios.2011.05.019

Cited by 76 publications

(48 citation statements)

References 38 publications

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“…Possibility of using nanobelt field effect transistor was reported by Cheng et al (2011), who showed detection of cTnI using functionalized Tin oxide (SnO 2 ) nanobelt field-effect transistors (FETs) Fig. 4.…”

Section: Nanobelt Field-effect Transistormentioning

confidence: 94%

Diagnostics on acute myocardial infarction: Cardiac troponin biomarkers

Fathil

Arshad

Gopinath

et al. 2015

Biosensors and Bioelectronics

204

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Section: Nanobelt Field-effect Transistormentioning

confidence: 94%

Diagnostics on acute myocardial infarction: Cardiac troponin biomarkers

Fathil

Arshad

Gopinath

et al. 2015

Biosensors and Bioelectronics

204

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“…The analysis in Fig. 9 shows that using a simple planar (macroscopic) device, Wen et al 49 and Won Hee Lee et al 32 achieved higher Sensitivity than the nanobelt arrays of Liu et al 26 and Cheng et al 25 or the nanowires of Elfström et al 121 This shows that even simple planar geometries can obtain high Sensitivity for biomolecule detection compared to more complex nanoscale geometries. As introduced previously, whilst nanoscale devices can offer improved subthreshold slope compared to conventional devices, nanoscale dimensions are not required to obtain a near-ideal subthreshold slope for a device.…”

mentioning

confidence: 89%

“…Measurements in this region of operation have been reported which show detection of streptavidin at the oxide-APTES-biotin interface. 25,35,44,49,120 Data from these publications is tabulated in ESI sections 5 and 9. † Three publications contained data with response as a function of streptavidin concentration, giving a Sensitivity of 72%, 162 63% 120 and 0.5%.…”

Section: Streptavidin Sensing Datamentioning

confidence: 99%

“…1 shows a simple planar device geometry akin to a single-gate MOSFET, a plethora of device geometries have been developed such as nanogap, [22][23][24] nanobelt, 25,26 nanoribbon 18,27-32 and nanowire 15,29,[33][34][35][36][37]38 structures. The application of additional lateral gates has been shown useful in tuning the carrier concentration of the device and pursuit of an optimal gate configuration is an active area of research.…”

Section: Operation Of Field-effect Sensorsmentioning

confidence: 99%

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Field-effect sensors – from pH sensing to biosensing: sensitivity enhancement using streptavidin–biotin as a model system

Lowe

Sun

Zeimpekis

et al. 2017

Analyst

136

107

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a Field-Effect Transistor sensors (FET-sensors) have been receiving increasing attention for biomolecular sensing over the last two decades due to their potential for ultra-high sensitivity sensing, label-free operation, cost reduction and miniaturisation. Whilst the commercial application of FET-sensors in pH sensing has been realised, their commercial application in biomolecular sensing (termed BioFETs) is hindered by poor understanding of how to optimise device design for highly reproducible operation and high sensitivity. In part, these problems stem from the highly interdisciplinary nature of the problems encountered in this field, in which knowledge of biomolecular-binding kinetics, surface chemistry, electrical double layer physics and electrical engineering is required. In this work, a quantitative analysis and critical review has been performed comparing literature FET-sensor data for pH-sensing with data for sensing of biomolecular streptavidin binding to surface-bound biotin systems. The aim is to provide the first systematic, quantitative comparison of BioFET results for a single biomolecular analyte, specifically streptavidin, which is the most commonly used model protein in biosensing experiments, and often used as an initial proofof-concept for new biosensor designs. This novel quantitative and comparative analysis of the surface potential behaviour of a range of devices demonstrated a strong contrast between the trends observed in pH-sensing and those in biomolecule-sensing. Potential explanations are discussed in detail and surfacechemistry optimisation is shown to be a vital component in sensitivity-enhancement. Factors which can influence the response, yet which have not always been fully appreciated, are explored and practical suggestions are provided on how to improve experimental design.

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“…13 One-dimensional (1D) nanostructure has been studied extensively as a transducer element in biosensors for their high surface to volume ratio, which results in the surface phenomena predomination over the chemistry and physics that happen in the bulk. 14,15 Amongst different 1D materials, single-walled carbon nanotubes (SWNTs) have emerged as a promising material for the development of label-free biosensor because of its extreme sensitivity towards resistance/ conductance changes upon adsorption/perturbation of analyte molecule on the SWNT surface and facile surface modification possibilities. 16,17 Further, the high electrical mobility of SWNTs enables developing low power microelectronics whereas the 1D nanostructure of SWNTs facilitates development of high-density sensor arrays within a limited space.…”

mentioning

confidence: 99%

Label-free chemiresistive biosensor for mercury (II) based on single-walled carbon nanotubes and structure-switching DNA

Gong

Sarkar

Badhulika

et al. 2013

Applied Physics Letters

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Herein, we present a sensitive, selective, and facile label-free DNA functionalized single-walled carbon nanotube (SWNT)-based chemiresistive biosensor for the detection of Hg 2þ . SWNTs were functionalized with Hg 2þ binding 15-bases long polyT oligonucleotide through covalent attachment using a bilinker molecule. The polyT was further hybridized with polyA to form a polyT-polyA duplex. When exposed to Hg 2þ the polyT-polyA duplex was dehybridized combined with switching of polyT structure, leading to change in resistance/conductance of the SWNT chemiresistor device. The device provided a significant response within 100 to 1000 nM of Hg 2þ concentration with a 6.72 Â 10 À3 nM À1 sensitivity. Mercury (Hg) is a worldwide concern in aquatic environments due to its toxicity and biomagnification in food webs. Elevated exposure to mercury can affect the cardiovascular system, gastro-intestinal system, liver, kidneys, and neurological system of the human body.1 Industrial wastewater from chlor-alkali and mineral industries, burning of fossil fuels, and incineration of municipal solid waste are the major sources of mercury contamination in the environment. The total global mercury emission from all sources has been estimated at 7500 tons per year.2 The United States Environmental Protection Agency (EPA) has mandated a drinking water upper limit of 2 ppb (10 nM) for mercury (II) ion concentration. 3Protein based Hg 2þ biosensor using electrochemical 4,5 and optical 6 techniques has been demonstrated. However, poor stability of proteins at ambient condition restricts its use for real application. These stability issues could be overcome by using DNA molecules that have excellent stability at ambient condition and do not require stringent storage conditions. Highly sensitive and selective detection of Hg 2þ ion based on thymine-Hg 2þ -thymine (T-Hg 2þ -T) structure-switching DNA using UV absorption, fluorescence, surface-enhanced Raman spectroscopy, resonance scattering, and electrochemical methods has been demonstrated. [7][8][9][10][11][12] However, these approaches require labels and/or sophisticated instruments. One-dimensional (1D) nanostructure has been studied extensively as a transducer element in biosensors for their high surface to volume ratio, which results in the surface phenomena predomination over the chemistry and physics that happen in the bulk.14,15 Amongst different 1D materials, single-walled carbon nanotubes (SWNTs) have emerged as a promising material for the development of label-free biosensor because of its extreme sensitivity towards resistance/ conductance changes upon adsorption/perturbation of analyte molecule on the SWNT surface and facile surface modification possibilities. 16,17 Further, the high electrical mobility of SWNTs enables developing low power microelectronics whereas the 1D nanostructure of SWNTs facilitates development of high-density sensor arrays within a limited space. In this work, we propose a label-free, chemiresistive biosensor for Hg 2þ ion detection based on polyTpolyA d...

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Functionalized SnO2 nanobelt field-effect transistor sensors for label-free detection of cardiac troponin

Cited by 76 publications

References 38 publications

Diagnostics on acute myocardial infarction: Cardiac troponin biomarkers

Diagnostics on acute myocardial infarction: Cardiac troponin biomarkers

Field-effect sensors – from pH sensing to biosensing: sensitivity enhancement using streptavidin–biotin as a model system

Label-free chemiresistive biosensor for mercury (II) based on single-walled carbon nanotubes and structure-switching DNA

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