Functions of the poly(ADP-ribose) polymerase superfamily in plants

Lamb, Rebecca; Citarelli, Matteo; Teotia, Sachin

doi:10.1007/s00018-011-0793-4

Cited by 57 publications

(59 citation statements)

References 151 publications

(182 reference statements)

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“…Niacin and nicotinamide serve as dietary precursors for the enzymatic cofactors NAD + and NADP + that are required in many redox reactions and are involved in fatty acid and carbohydrate metabolism (Wahlberg et al, 2000). NAD + is also a critical metabolite in cellular signaling reactions as it serves as a substrate for ADP-ribosyltransferases and ADPribosyl cyclases to generate ADP-ribosylated substrates and cyclic ADP-ribose, respectively (Lepiniec et al, 1995;DoucetChabeaud et al, 2001;Virá g and Szabó , 2002;Hassa et al, 2006;Pollak et al, 2007;Lamb et al, 2011). ADP-ribosylation plays a critical role in various cellular processes, such as DNA repair (Doucet-Chabeaud et al, 2001), stress responses (Monks et al, 2006;Adams-Phillips et al, 2008), cell cycle control (Shiotani et al, 2006), and chromatin structure (Laroche et al, 1980;Houben et al, 2007), and cyclic ADP-ribose is important in the control of the cellular calcium flux (Higashida et al, 2001;Pollak et al, 2007;Morgan and Galione, 2008).…”

Section: Vitamin B 2 (Riboflavin)mentioning

confidence: 99%

Vitamin Deficiencies in Humans: Can Plant Science Help?

et al. 2012

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The term vitamin describes a small group of organic compounds that are absolutely required in the human diet. Although for the most part, dependency criteria are met in developed countries through balanced diets, this is not the case for the five billion people in developing countries who depend predominantly on a single staple crop for survival. Thus, providing a more balanced vitamin intake from high-quality food remains one of the grandest challenges for global human nutrition in the coming decade(s). Here, we describe the known importance of vitamins in human health and current knowledge on their metabolism in plants. Deficits in developing countries are a combined consequence of a paucity of specific vitamins in major food staple crops, losses during crop processing, and/or overreliance on a single species as a primary food source. We discuss the role that plant science can play in addressing this problem and review successful engineering of vitamin pathways. We conclude that while considerable advances have been made in understanding vitamin metabolic pathways in plants, more cross-disciplinary approaches must be adopted to provide adequate levels of all vitamins in the major staple crops to eradicate vitamin deficiencies from the global population.

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Section: Vitamin B 2 (Riboflavin)mentioning

confidence: 99%

Vitamin Deficiencies in Humans: Can Plant Science Help?

et al. 2012

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“…As mentioned above for vertebrates, plant PARPs are stimulated by multiple types of stress and can promote either cell survival or cell death. AtPARP1 and AtPARP2 localize to the mitotic spindle and thus may have functions similar to those of Tankyrase1 and human PARP3 in preventing fusion of sister chromatids during cell division [73]. Indirect evidence indicates that AtPARP1 and AtPARP2 function in DNA repair in vivo .…”

Section: Introductionmentioning

confidence: 98%

“…Of the three PARPs with enzymatic activity, AtPARP2 is homologous to HsPARP1, while AtPARP1 and AtPARP3 more closely resemble HsPARP3. Both AtPARP1 and AtPARP2 are ubiquitously expressed, but AtPARP3 expression is confined to seeds under standard growth conditions [73].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Poly(ADP-Ribose) Polymerases in Arabidopsis Telomere Biology

et al. 2014

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Maintaining the length of the telomere tract at chromosome ends is a complex process vital to normal cell division. Telomere length is controlled through the action of telomerase as well as a cadre of telomere-associated proteins that facilitate replication of the chromosome end and protect it from eliciting a DNA damage response. In vertebrates, multiple poly(ADP-ribose) polymerases (PARPs) have been implicated in the regulation of telomere length, telomerase activity and chromosome end protection. Here we investigate the role of PARPs in plant telomere biology. We analyzed Arabidopsis thaliana mutants null for PARP1 and PARP2 as well as plants treated with the PARP competitive inhibitor 3-AB. Plants deficient in PARP were hypersensitive to genotoxic stress, and expression of PARP1 and PARP2 mRNA was elevated in response to MMS or zeocin treatment or by the loss of telomerase. Additionally, PARP1 mRNA was induced in parp2 mutants, and conversely, PARP2 mRNA was induced in parp1 mutants. PARP3 mRNA, by contrast, was elevated in both parp1 and parp2 mutants, but not in seedlings treated with 3-AB or zeocin. PARP mutants and 3-AB treated plants displayed robust telomerase activity, no significant changes in telomere length, and no end-to-end chromosome fusions. Although there remains a possibility that PARPs play a role in Arabidopsis telomere biology, these findings argue that the contribution is a minor one.

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“…In contrast to the 17 PARPs in humans, the reference plant Arabidopsis genome encodes three PARPs (AtPARP1, AtPARP2, and AtPARP3) with the conserved ARTD motif (Fig 1B) [11,12]. AtPARP1 bears the highest homology to HsPARP-1, which is the most active, ubiquitous, and abundant member of PARPs in humans.…”

Section: Adp-ribosylation: Similarities and Differences In Plants Andmentioning

confidence: 99%