Fundamental limit of detection of photonic biosensors with coherent phase read-out

Molina-Fernández, Í.; Leuermann, Jonas; Ortega‐Moñux, Alejandro; Wangüemert‐Pérez, J. Gonzalo; Halir, Robert

doi:10.1364/oe.27.012616

Cited by 41 publications

(27 citation statements)

References 37 publications

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“…In the past year, Optics Express has published some articles dealing with state-of-the-art Mach-Zehnder interferometers and their improvements. Learning from telecommunications, a coherent phase readout by directional coupler and differential detector detection [316], an optimizing optical attenuation with varying electrical power in the thermos-optic phase shifter on the reference arm of the Mach-Zehnder chip [317] or finally implementing an electro-optic comb sensor with some electronics for the phase modulation [318] were fabricated.…”

Section: Dual Pathwaymentioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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Direct optical detection has proven to be a highly interesting tool in biomolecular interaction analysis to be used in drug discovery, ligand/receptor interactions, environmental analysis, clinical diagnostics, screening of large data volumes in immunology, cancer therapy, or personalized medicine. In this review, the fundamental optical principles and applications are reviewed. Devices are based on concepts such as refractometry, evanescent field, waveguides modes, reflectometry, resonance and/or interference. They are realized in ring resonators; prism couplers; surface plasmon resonance; resonant mirror; Bragg grating; grating couplers; photonic crystals, Mach-Zehnder, Young, Hartman interferometers; backscattering; ellipsometry; or reflectance interferometry. The physical theories of various optical principles have already been reviewed in detail elsewhere and are therefore only cited. This review provides an overall survey on the application of these methods in direct optical biosensing. The "historical" development of the main principles is given to understand the various, and sometimes only slightly modified variations published as "new" methods or the use of a new acronym and commercialization by different companies. Improvement of optics is only one way to increase the quality of biosensors. Additional essential aspects are the surface modification of transducers, immobilization strategies, selection of recognition elements, the influence of non-specific interaction, selectivity, and sensitivity. Furthermore, papers use for reporting minimal amounts of detectable analyte terms such as value of mass, moles, grams, or mol/L which are difficult to compare. Both these essential aspects (i.e., biochemistry and the presentation of LOD values) can be discussed only in brief (but references are provided) in order to prevent the paper from becoming too long. The review will concentrate on a comparison of the optical methods, their application, and the resulting bioanalytical quality.

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Section: Dual Pathwaymentioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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“…Using the additional degree of freedom afforded by a shift, ξ, between the loading segments this approach has enabled the demonstration of filter bandwidths as narrow as 200pm with 30dB extinction [11]. The enhanced modal interaction can also be exploited to improve the sensitivity of photonic biosensors [12], which through careful design of the complete sensing system will result in better detection limits [13].…”

Section: High Performance Subwavelength Devicesmentioning

confidence: 99%

High performance silicon photonic devices based on practical metamaterials

Halir

Luque‐González

Sánchez‐Postigo

et al. 2019

2019 24th OptoElectronics and Communications Conference (OECC) and 2019 International Conference on Photonics in Switching and

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“…We have analytically studied the impact of these factors on the LOD, arring at a closed form expression. This expression is valid for both interferometric and ring resonators with coherent detection scheme and holds for interferometric architectures with conventional read-out, at the quadrature point, too, thereby enabling us to formulate clear guidelines for sensor optimization [5]. Fig.…”

mentioning

confidence: 90%

“…1(b The LOD is the smallest change in analyte that can be detected by the biosensing system. In addition to its dependency on the waveguide sensitivity, it is critically limited by the signal attenuation and noise [5]. We have analytically studied the impact of these factors on the LOD, arring at a closed form expression.…”

mentioning

confidence: 99%

Comparing the Fundamental Limit of Detection for Interferometric and Resonant Biosensors with Coherent Phase Read-Out

Leuermann

Molina-Fernández

Ortega‐Moñux

et al. 2019

2019 Conference on Lasers and Electro-Optics Europe &Amp; European Quantum Electronics Conference (CLEO/Europe-EQEC)

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Fundamental limit of detection of photonic biosensors with coherent phase read-out

Cited by 41 publications

References 37 publications

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

High performance silicon photonic devices based on practical metamaterials

Comparing the Fundamental Limit of Detection for Interferometric and Resonant Biosensors with Coherent Phase Read-Out

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