Fundus autofluorescence and spectral domain optical coherence tomography as predictors for long-term functional outcome in rhegmatogenous retinal detachment

Poulsen, Christina Doefler; Petersen, M Prütz; Green, A; Pető, Tünde; Grauslund, Jakob

doi:10.1007/s00417-018-04222-w

Cited by 20 publications

(8 citation statements)

References 25 publications

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“…e metabolic stress induced on the retina by the detachment and the following surgical intervention can be observed by mapping fundus fluorophores [7]. ese naturally autofluorescent substances can be imaged with fundus autofluorescence (AF), a noninvasive modality that provides an indirect marker of the metabolic activity of the outer retina and the balance between photoreceptor outer segment turnover and RPE phagocytotic ability [8].…”

Section: Introductionmentioning

confidence: 99%

Autofluorescence Imaging in the Long-Term Follow-Up of Scleral Buckling Surgery for Retinal Detachment

Salvanos

Björnsson

Vitelli

et al. 2022

Journal of Ophthalmology

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Purpose. To analyse fundus autofluorescence (AF) changes in retinal reattachment following primary scleral buckling (SB) surgery for rhegmatogenous retinal detachment (RRD). Methods. Prospective noninterventional chart review study. AF images were reviewed for peripheral and central changes and compared to clinical and OCT findings. Results. A total of 73 eyes from 69 patients were included, four presenting with bilateral RRD. Mean age was 55 ± 12 years, male/female ratio 40/29, fovea-on/-off RRD 43/30, and mean follow-up time 376 ± 270 days, with a mean of 5 ± 3 postoperative visits. Preoperatively, RRD was seen as a hypofluorescent area with a hyperfluorescent leading edge. Immediately postoperatively, three types of cryopexy could be differentiated, gradually transforming to scleral hyperfluorescence. Buckle tightening produced alternating hyper-/hypofluorescent streaks, and demarcation lines showed a persistent rugged hyperfluorescent signal. Choroidal detachment led to transient hypofluorescence, whereas vortex vein compression induced persistent hypofluorescence. Peripheral retinal folds were hyperfluorescent and the drainage site was hypofluorescent. AF was highly sensitive in detecting even small amounts of hyperfluorescent persistent subretinal fluid (SRF) that showed a slow resolution during follow-up. A granular “salt-and-pepper-” like pattern in the central macula was seen in 80% of eyes with fovea-off RRD and alternating streaks in 10%. Findings from OCT imaging correlated well with AF regarding SRF, macular oedema, retinal pigment epithelial detachment, and presence of a subretinal scar, but only moderately in epiretinal membrane formation and choroidal folds. Conclusions. AF is a useful, noninvasive, adjuvant tool in the long-term follow-up after SB surgery.

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Section: Introductionmentioning

confidence: 99%

Autofluorescence Imaging in the Long-Term Follow-Up of Scleral Buckling Surgery for Retinal Detachment

Salvanos

Björnsson

Vitelli

et al. 2022

Journal of Ophthalmology

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“…1–3 Optical coherence tomography (OCT) has been previously used to evaluate macular alterations occurring after surgery for RRD repair, helping additionally in defining prognostic factors that may predict the postoperative anatomic and visual outcome. 4–12 Coppola et al reported that the main structural cross-sectional OCT findings after vitreoretinal surgery for RRD included subretinal fluid, subretinal blebs, retinal folds, subretinal perfluorocarbon liquids, macular alterations related to silicone oil, epiretinal membranes, proliferative vitreoretinopathy, cystoid macular edema, macular holes, and recurrent retinal detachment. 13 Additionally, thinning of macular ganglion cell-inner plexiform layer has been observed in patients with RRD treated with PPV, 14 while thickening of peripapillary retinal nerve fiber layer in successfully operated RRD eyes using vitrectomy and silicone oil endotamponade has been also reported.…”

Section: Introductionmentioning

confidence: 99%

Evolution of macular microvasculature and retinal layers alterations in patients with macula off retinal detachment after vitrectomy

Chatziralli

Theodossiadis

Chatzirallis

et al. 2021

European Journal of Ophthalmology

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Purpose: To examine the changes in retinal microvasculature in association with retinal layers’ condition in patients with rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy (PPV). Methods: Participants in this study were 89 patients with macula off RRD, who were successfully treated with PPV and gas tamponade without internal limiting membrane peeling, in two centers. All participants underwent best corrected visual acuity (BCVA) measurement, slit-lamp examination, fundoscopy, spectral domain-optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA) at week 5, month 3 and month 6 postoperatively. The fellow untreated eyes were also examined and served as control data. Results: A statistically significant enlargement in foveal avascular zone (FAZ) in both superficial capillary plexus (SCP) and deep capillary plexus (DCP), accompanied with a statistically significant thinning of inner retinal layers, was noticed 5 weeks postoperatively. These changes, namely FAZ enlargement and thinning of inner retinal layers, in the operated eyes compared to the fellow eyes, remained unchanged till month 6 postoperatively. BCVA improved significantly from week 5 to months 3 and 6 postoperatively. The improvement in BCVA was associated with the gradual ellipsoid zone (EZ) recovery from the first (week 5) till the last examination (month 6). Conclusions: The FAZ enlargement in the operated eyes was accompanied with a statistically significant thinning in the inner retinal layers. Inter-correlation of BCVA and EZ integrity was noticed.

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“…However, the anatomical success is not always linked to functional visual recovery and involvement of the macula in the retinal detachment pathogenesis is one of the most important prognostic factors for visual prognosis [ 8 ]. In clinical practice the combination of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) has allowed a more detailed study of some suboptimal functional recovery causes after surgery, including a refractory cystoid macular edema (CME), persistent subretinal fluid (SRF) and epiretinal membrane (ERM) combined with alteration of the inner segment/outer segment (IS/OS) [ 9 , 10 , 11 , 12 , 13 ], and a more accurate analysis of the pathophysiological changes occurring in the macular microcirculation in retinal diseases, such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and macular telangiectasias [ 14 ]. Several studies have investigated retinal microvasculature and its changes in ocular diseases after vitreoretinal surgery.…”

Section: Introductionmentioning

confidence: 99%

Early Structural and Vascular Changes after Within-24 Hours Vitrectomy for Recent Onset Rhegmatogenous Retinal Detachment Treatment: A Pilot Study Comparing Bisected Macula and Not Bisected Macula

D’Aloisio

Gironi

Verdina

et al. 2022

JCM

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Background: In this study we aimed at investigating macular perfusion/anatomical changes in eyes with early onset rhegmatogenous retinal detachment (RRD) after prompt surgery within 24 hours, comparing a bisected macula and not bisected macula RRD. Methods: In this prospective observational study, 14 eyes of 14 patients who underwent within-24 hours vitreoretinal surgery for early onset RRD were enrolled. Patients were further divided into two subgroups: the not bisected macula group (NBM group) and the bisected macula group (BM group). At baseline and 3-month follow up, macular architecture and vessel analysis were assessed using optical coherence tomography angiography (OCTA) imaging. In detail, quantitative and qualitative analyses of the macular area were performed to quantify topographical retinal perfusion changes after surgery, calculating the foveal avascular zone (FAZ), vessel density (VD) and vessel length density (VLD) at the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Results: Most cases (43%) were superotemporal RRD. Primary retinal reattachment was obtained in all cases, without recurrences within 3-month follow up. After surgery, a significant FAZ enlargement was observed at both the SCP and DCP level (p < 0.001; p < 0.05), with a significant effect of time noted between the two time points in the NBM and BM subanalysis (F = 3.68; p < 0.017). An excellent functional outcome was maintained for the whole follow-up. On the other hand, after surgery, perfusion parameters did not change significantly apart from the vessel density of the inferior macular sector at the DCP level (p = 0.03). Conclusions: Our findings suggest that the macular perfusion of eyes with RRD is still preserved if the surgery is performed really promptly, thus highlighting the great importance of a correct timing for surgery. OCTA analysis allows for a better understanding of the pathophysiological mechanisms underneath early vascular microarchitecture modifications of the posterior pole in retinal detachment, differentiating the two types of RRD not completely involving the fovea (BM and NBM).

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Fundus autofluorescence and spectral domain optical coherence tomography as predictors for long-term functional outcome in rhegmatogenous retinal detachment

Abstract: Fundus autofluorescence and spectral domain optical coherence tomography as predictors for long-term functional outcome in rhegmatogenous retinal detachment.

Cited by 20 publications

References 25 publications

Autofluorescence Imaging in the Long-Term Follow-Up of Scleral Buckling Surgery for Retinal Detachment

Autofluorescence Imaging in the Long-Term Follow-Up of Scleral Buckling Surgery for Retinal Detachment

Evolution of macular microvasculature and retinal layers alterations in patients with macula off retinal detachment after vitrectomy

Early Structural and Vascular Changes after Within-24 Hours Vitrectomy for Recent Onset Rhegmatogenous Retinal Detachment Treatment: A Pilot Study Comparing Bisected Macula and Not Bisected Macula

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