Fundus pulsation measurements in diabetic retinopathy

Schmetterer, Leopold; Salomon, Alexander K.; Rheinberger, A.; Unfried, C; Lexer, Franz; Wolzt, Michael

doi:10.1007/bf01739637

Cited by 21 publications

(18 citation statements)

References 24 publications

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“…This is in keeping with several studies in STZ induced diabetic rats25-27 and with a recent study using pneumotonometry for the assessment of pulsatile ocular blood flow 28. However, in a previous study employing laser interferometry we did not find increased FPA in the early stages of diabetic retinopathy 29. Several differences between this previous cross sectional trial and the present study exist, which could explain this discrepancy.…”

Section: Discussionsupporting

confidence: 90%

Ocular haemodynamics and colour contrast sensitivity in patients with type 1 diabetes

Findl

Dallinger²,

Rami³

et al. 2000

British Journal of Ophthalmology

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Background-There is evidence that altered ocular blood flow is involved in the development and progression of diabetic retinopathy. However, the nature of these perfusion abnormalities is still a matter of controversy. Ocular haemodynamics were characterised with two recently introduced methods. Methods-The cross sectional study was performed in 59 patients with type 1 diabetes with a diabetes duration between 12 and 17 years and an age less than 32 years and a group of 25 age matched healthy controls. Scanning laser Doppler flowmetry and laser interferometric measurement of fundus pulsation amplitude were used to assess retinal and pulsatile choroidal blood flow, respectively. In addition, colour contrast sensitivity along the tritan axis was determined. Results-Fundus pulsation amplitude, but not retinal blood flow, increased with the progression of diabetic retinopathy. Retinal blood flow was influenced by plasma glucose levels (r = 0.32), whereas fundus pulsation amplitude was associated with HbA 1c (r = 0.30). In addition, a negative correlation between the colour contrast sensitivity along the tritan axis and retinal blood flow was observed. Conclusions-The present study indicates that pulsatile choroidal blood flow increases with the progression of diabetic retinopathy. Increased retinal blood flow appears to be related to loss of colour sensitivity in patents with type 1 diabetes. (Br J Ophthalmol 2000;84:493-498) Altered ocular blood flow may contribute to the development and progression of diabetic retinopathy. However, the exact nature of ocular blood flow abnormalities in diabetes has not yet been established and the results obtained in patients with type 1 diabetes and type 2 diabetes strongly depend on the technique used for the assessment of ocular haemodynamics. Both, increased 1-3 and decreased retinal blood flow 4 5 have been observed in patients with diabetes compared with healthy controls. A recent study using laser Doppler velocimetry for the assessment of retinal blood flow indicates that retinal perfusion is already increased in patients with type 1 diabetes before the clinical onset of diabetic retinopathy.6 This observation has further supported the concept that increased retinal blood flow may have a key role in the development of diabetic retinopathy. 8The purpose of the present study was to determine whether retinal and choroidal blood flow are altered in the early stages of diabetic retinopathy. Retinal blood flow was assessed with scanning laser Doppler flowmetry.9 Pulsatile choroidal blood flow was assessed with laser interferometric measurement of fundus pulsation. 10Ocular haemodynamic factors were compared with the results of colour contrast sensitivity testing. This was done in an eVort to establish a relation between alterations in ocular haemodynamics and loss of colour contrast sensitivity. In order to minimise the eVect of potentially confounding factors such as duration of diabetes or age we focused on a study population with type 1 diabetes with a duration of 1...

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Section: Discussionsupporting

confidence: 90%

Ocular haemodynamics and colour contrast sensitivity in patients with type 1 diabetes

Findl

Dallinger²,

Rami³

et al. 2000

British Journal of Ophthalmology

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“…The thickness of the retina in the area where we did the recordings (peripapillary region) is approximately 500 μm [27]. The movement of the retina resulting from the fundus pulsation in diabetic patients without diabetic retinopathy has been reported to average 3.29 (±0.98) μm [26]. Therefore, it is unlikely that the choroid is directly involved in the scanning area because of the movement forward towards the camera.…”

Section: Discussionmentioning

confidence: 99%

Correlation between capillary blood flow of retina estimated by SLDF and circulatory parameters of retrobulbar blood vessels estimated by CDI in diabetic patients

Dimitrova¹,

Tomita²,

Kato³

2005

Graefe's Arch Clin Exp Ophthalmol

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“…Since the retina is also dependent on the choroid for its nutrition (Tornquist & Alm 1979;Alm 1992) and oxygenation (Alm & Bill 1972), the choroidal vasculature should also play a role in the pathogenesis of diabetic retinopathy. Surprisingly little attention has been paid to choroidal blood flow in patients with diabetes (Zaharia et al 1987;Langham et al 1991;Schmetterer et al 1997;Schmitt & Hessemer 1997;MacKinnon et al 1997).…”

Section: R Etinal Blood Flow Abnormalitiesmentioning

confidence: 99%