Fungal Peritonitis Caused by <i>Rhodotorula mucilaginosa</i> in a CAPD Patient Treated with Liposomal Amphotericin B: A Case Report and Literature Review

Franconieri, Frédéric; Bonhomme, Julie; Doriot, Aline; Bonnamy, Cécile; Ficheux, Maxence; Lobbedez, Thierry; Béchade, Clémence

doi:10.3747/pdi.2017.00096

Cited by 12 publications

(15 citation statements)

References 17 publications

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“…Patient 2 had intravenous (IV) antibiotics for 2 days because intraperitoneal (IP) injection was painful, followed by IP antibiotics as PD restarted (day 2). Patient 6 had IV amphotericin B as it cannot be injected IP (22). Patient 9 had IP antibiotics even during the temporary transfer to HD: 1,000 mL of dialysate containing cefazolin was administered daily during the temporary transfer to HD.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous Removal and Reinsertion of the PD Catheter in Relapsing Peritonitis

et al. 2019

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Background Relapsing peritonitis in peritoneal dialysis (PD) is associated with lower cure rates and more hemodialysis (HD) transfers, as catheter removal is recommended in these situations. The aim of our study was to evaluate the continuation of PD without perioperative transfer to HD in patients who underwent a simultaneous catheter removal and replacement for relapsing peritonitis. Methods This was a retrospective monocentric study. Patients with simultaneous catheter removal and replacement for relapsing peritonitis or peritonitis at high risk of relapse (fungal or Pseudomonas infection) between 1 January 2007 and 31 December 2016 were included. The events of interest were the continuation of PD without perioperative transfer to HD, postoperative complications, new infection with the same organism, and technique survival. Results Of the 271 incident patients in PD during this period, 11 had a simultaneous catheter removal and replacement for relapsing peritonitis ( 8 ) or high risk of relapse peritonitis ( 3 ). Eight (72.7%) patients pursued PD without transfer to HD. Six infections were due to microorganisms other than gram-positive cocci. At 1 year, 7 (63.6%) of the 11 patients were still on PD. After the surgery, there were no peritonitis or catheter-related infections caused by the same organism. Conclusion Simultaneous catheter removal and replacement for peritonitis appears to be an effective procedure for maintaining patients on PD.

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Section: Resultsmentioning

confidence: 99%

Simultaneous Removal and Reinsertion of the PD Catheter in Relapsing Peritonitis

et al. 2019

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“…Summarizing, CKD patients are usually colonized by Rhodotorula spp. [5, 14]; moreover their immunosuppressed state [17] and considering the potential of virulence of this microorganism demonstrated in current study, we can infer CKD patients are critical risk group for disseminated infection by R. mucilaginosa .…”

Section: Discussionmentioning

confidence: 81%

Approaches by Rhodotorula mucilaginosa from a chronic kidney disease patient for elucidating the pathogenicity profile by this emergent species

Jarros¹,

Veiga²,

Corrêa³

et al. 2019

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26Background: Traditionally known as a common contaminant, Rhodotorula mucilaginosa is 27 among the leading causes of invasive fungal infections by non-candida yeasts. They affect 28 mainly immunocompromised individuals, often mimicking the cryptococcosis infection, 29 despite invasive infections by Rhodotorula are still not well explained. Thus, here we aimed to 30 characterize microbiologically clinical isolates of R. mucilaginosa isolated from colonization 31 of a patient with chronic renal disease (CKD), as well as to evaluate their phylogeny, antifungal 32 susceptibility, virulence, and pathogenicity in order to infer the potential to become a possible 33 infection. 34 Methodology/Principal Findings: For this study, two isolates of R. mucilaginosa from oral 35 colonization of a CKD patient were isolated, identified and characterized by classical 36 (genotypic and phenotypic) methods. Susceptibility to conventional antifungals was evaluated, 37 followed by biofilm production, measured by different techniques (total biomass, metabolic 38 activity, colony forming units and extracellular matrix quantification). Finally, the 39 pathogenicity of yeast was evaluated by infection of Tenebrio molitor larvae. 40All isolates were resistant to azole and sensitive to polyenes and they were able to adhere and 41 form biofilm on the abiotic surface of polystyrene. In general, similar profiles among isolates 42 were observed over the observed periods (2, 24, 48 and 72 hours). Regarding extracellular 43 matrix components of biofilms at different maturation ages, R. mucilaginosa was able to 44 produce eDNA, eRNA, proteins, and polysaccharides that varied according to time and the 45 strain. The death curve in vivo model showed a large reduction in the survival percentage of 46 the larvae was observed in the first 24 hours, with only 40% survival at the end of the 47 Conclusions/Significance: We infer that colonization of chronic renal patients by R. 49 mucilaginosa offers a high risk of serious infection. And also emphasize that the correct 50 identification of yeast is the main means for an efficient treatment. 51 52 53 3 Author Summary 54The genus Rhodotorula is known to be a common contaminant, however, it has been 55 increasing in the last years, reports of different forms infections by this yeast, reaching mainly 56 individuals with secondary diseases or with low immunity. However, very little is known about 57 the mechanism that triggers the disease. Thus, this study aims to characterize microbiologically 58 clinical isolates of R. mucilaginosa isolated from a patient with chronic renal disease, as well 59 as to evaluate their phylogeny, antifungal susceptibility, virulence, and pathogenicity in order 60 to infer the potential to become a possible infection. It was possible to characterize in general 61 the clinical isolates, to determine that they are resistant to an important class of the antifungal 62 agents which are the azoles. In addition, they are able to adhere and to form biofilm on abiotic 63 surfaces, t...

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“…There was a large outbreak of Exserohilum rostratum infections in September 2012, associated with epidural and intra-articular injections of methylprednisolone acetate contaminated with Exserohilum rostratum (3). Fungal peritonitis caused by Exserohilum is rare, as it is usually caused by Candida or Aspergillus species (4). Culture, histopathology, and polymerase chain reaction (PCR) assay can be used to diagnose Exserohilum infection.…”

Section: Discussionmentioning

confidence: 99%

Exserohilum Peritonitis in Peritoneal Dialysis in Northern China: A Case Report

Liu

Gong

et al. 2019

Perit Dial Int

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Fungal Peritonitis Caused by Rhodotorula mucilaginosa in a CAPD Patient Treated with Liposomal Amphotericin B: A Case Report and Literature Review

Cited by 12 publications

References 17 publications

Simultaneous Removal and Reinsertion of the PD Catheter in Relapsing Peritonitis

Simultaneous Removal and Reinsertion of the PD Catheter in Relapsing Peritonitis

Approaches by Rhodotorula mucilaginosa from a chronic kidney disease patient for elucidating the pathogenicity profile by this emergent species

Exserohilum Peritonitis in Peritoneal Dialysis in Northern China: A Case Report

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