Fungi and Fungal Metabolites for the Improvement of Human and Animal Nutrition and Health

Dufossé, Laurent; Fouillaud, Mireille; Caro, Yanis

doi:10.3390/jof7040274

Cited by 15 publications

(9 citation statements)

References 23 publications

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“…Among them, the metabolites derived from fungi contain biologically active ingredients of considerable commercial value, including oligosaccharides, exopolysaccharides (EPS), enzymes, peptides, vitamins, and biosurfactants. These metabolites are widely used as main raw materials for pharmaceuticals, functional foods, and cosmetic products [5][6][7][8][9]. Packed with thousands of antioxidants and anti-inflammatory properties, they have been widely used to fight aging by improving the skin's natural defenses, restoring skin elasticity, increasing moisture content, promoting collagen synthesis, and exhibiting skin-whitening effects [4,5].…”

Section: Introductionmentioning

confidence: 99%

Ceriporia lacerata Mycelium Culture Medium as a Novel Anti-Aging Microbial Material for Cosmeceutical Application

Kim

An²,

Hwang³

et al. 2021

Cosmetics

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Skincare is very critical in preventing aging and skin trouble, which is difficult to recover if progressed. However, the development of effective anti-aging solutions is still on the horizon. The purpose of this study was to evaluate the functional efficacy of Ceriporia lacerata exo-pharmaceutical substance (CLEPS) in view of its use in innovative skin care cosmetics. CLEPS was found to have no cytotoxicity against normal human dermal fibroblasts and B16 melanoma cells in a wide concentration range of 0.05–7 mg/mL. It exhibited a whitening effect by inhibiting melanin synthesis comparable to that of the respective reference compound (arbutin). Notably, CLEPS not only substantially increased collagen (65.4%) and filaggrin synthesis (36%), but also significantly inhibited the activity of collagenase (93.4%), suggesting that CLEPS could prevent skin barrier damage or skin wrinkles. In addition, it showed an excellent anti-inflammatory effect and wound-healing effect. Overall, CLEPS exhibited exceptional anti-aging effects in human skin cells, designating as a potential natural cosmeceutical ingredient.

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Section: Introductionmentioning

confidence: 99%

Ceriporia lacerata Mycelium Culture Medium as a Novel Anti-Aging Microbial Material for Cosmeceutical Application

Kim

An²,

Hwang³

et al. 2021

Cosmetics

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“…Fungal biomass is a large portfolio of proteins, vitamins, minerals, metabolites, and bioactive compounds for pharmaceutical applications, especially as antibiotics. 1 The fungus Aspergillus terreus is a storehouse of bioactive compounds and “terrein” is one of the most active biomolecules obtained from it. Terrein was first isolated and described in 1935, but its structure (4, 5-dihydroxy-3-[(E)-10-propenyl]-2-cyclopenten- 1-one, C 8 H 10 O 3 ) was elucidated in the 1950s.…”

Section: Introductionmentioning

confidence: 99%

A Focused Review of the Pharmacological Potentials of Terrein as an Anticancer Agent

Goutam

Sharma

Yadav

et al. 2023

Natural Product Communications

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Terrein is one of the most important biomolecules of fungal origin being studied from a medicinal perspective. Secondary metabolites are the intermediate products produced during the metabolism of organisms for a large number of functions, for example, defense and communication signals. From the outset, terrein has largely been studied as an anticancer secondary biomolecule. Aspergillus terreus is the only fungal source of some valuable drugs and mycotoxins. From the beginning, a few species of Aspergillus were known to be viable chemical factories. Terrein is a potent biological molecule present in the fungus that is responsible for its medicinal and agricultural values. Numerous evaluations conducted on terrein showed it to have marked biological activities (antimicrobial, antiproliferative, anti-oxidative, and others). To date, terrein has emerged as a very attractive therapeutic regimen against cancer due to its dual targeting nature; tumor angiogenesis and cell proliferation. This focused review provides details of the therapeutic value of terrein and its modes of action as an anticancer agent. Besides this, terrein has other marked bioactivities and manifold uses in the field of medicine, which have also been discussed here.

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“…Fungi are an interesting, increasingly studied, and growing source of new molecules with potential benefits on human health [4][5][6] Given their role in human nutrition in many countries, it is not surprising that their potential beneficial contribution to human health is an ever-expanding field. In particular, it is the saprotrophic species, cultivated on a large scale, that are also of considerable economic importance.…”

Section: Introductionmentioning

confidence: 99%

A novel method for the extraction and characterization of metabolites from Basidiomycota: Pleurotus ostreatus (Jacq.) P. Kumm., 1871 as a case study

Benvenuti,

Piazza,

Salis

et al. 2023

Separation Science Plus

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In recent years, the interest in the exploitation of fungal metabolites has grown considerably, given their application in numerous sectors involving human health. However, their identification and characterization by conventional analytical approaches is generally limited to single families of molecules per method of analysis. This constitutes a limiting factor of primary importance in the study of both the metabolic pattern of a single fungal sample and the discovery of its possible applications. In this work, a reverse‐phase high‐performance liquid chromatography coupled with mass spectrometry method for the profile determination of primary and secondary metabolites produced by the oyster‐mushroom Pleurotus ostreatus (Jacq.) P. Kumm., 1871, has been developed. By using a concomitant extraction in three different polarity‐decreasing solvents, namely methanol, ethanol, and acetonitrile, this method allowed the simultaneous analysis of all extracted metabolites belonging to the widest possible range of chemical families, giving an advantage for both qualitative and quantitative determination of known and unknown compounds. The method appears to be valuable and robust for the study of complex matrices like raw fungi extract such as those of Pleurotus ostreatus cultivated on different substrates and/or exposed to multiple stressors.

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Fungi and Fungal Metabolites for the Improvement of Human and Animal Nutrition and Health

Abstract: Fungi: 1, 2, 3, [...]

Cited by 15 publications

References 23 publications

Ceriporia lacerata Mycelium Culture Medium as a Novel Anti-Aging Microbial Material for Cosmeceutical Application

Ceriporia lacerata Mycelium Culture Medium as a Novel Anti-Aging Microbial Material for Cosmeceutical Application

A Focused Review of the Pharmacological Potentials of Terrein as an Anticancer Agent

A novel method for the extraction and characterization of metabolites from Basidiomycota: Pleurotus ostreatus (Jacq.) P. Kumm., 1871 as a case study

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