Fungicidal Activity of Liranaftate Against Trichophyton rubrum.

Oku, Yukio; Sakuma, Keita; Yokoyama, Koji; Miyaji, Makoto

doi:10.3314/jjmm.43.181

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Antifungal Drugs As a Modulator Of Keratinocyte Chemokine Pr1

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Cited by 7 publications

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“…Thus, CXCL8 was the most greatly enhanced chemokine/cytokine by the fungal elements, as has been reported previously (86). In this in vitro system, we added liranaftate, a Japanese representative thiocarbamate antifungal agent (87). β‐glucan‐augmented production of CXCL8 was profoundly suppressed by the addition of liranaftate to the culture in a dose‐dependent manner.…”

Section: Antifungal Drugs As a Modulator Of Keratinocyte Chemokine Prmentioning

confidence: 99%

Epidermal chemokines and modulation by antihistamines, antibiotics and antifungals

Tokura

Miwa

Kabashima

2007

Experimental Dermatology

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Growing evidence has demonstrated that chemokines released from epidermal cells control inflammatory skin diseases. Keratinocytes elaborate both Th1-and Th2-associated chemokines, although the former is more abundantly produced than the latter. Downmodulation of keratinocyte production of chemokines is one of the therapeutic approaches for cutaneous inflammatory disorders. Recent observations have shown that keratinocyte chemokine production can be modulated by wellused drugs, including antihistamines, antibiotics and antifungals. Utilization of the beneficial side effects of these drugs may by clinically valuable.

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Section: Antifungal Drugs As a Modulator Of Keratinocyte Chemokine Prmentioning

confidence: 99%