Fungicide and fungiostatic effects of xanthoxyline

Filho, Valdir Cechinel; Lima, Edeltrudes O.; Morais, Verônica M. F.; Gomes, Sosigenas T. A.; Miguel, Obdúlio Gomes; Yunes, Rosendo A.

doi:10.1016/0378-8741(96)01436-5

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Although the observed activities are not profound, the high content of antifungal constituents and their probable additive or synergistic effects are compatible with the traditional use of the plant for wound healing. The results are compatible with previous reports (Filho et al, 1996;Leifertova et al, 1975;Pagnocca et al, 1996). In particular, the fungicidic and fungistatic effect of xanthoxylin is of interest (Pinheiro et al, 1999).…”

Section: Resultssupporting

confidence: 95%

Antifungal constituents of Melicope borbonica

Simonsen

Adsersen

Bremner

et al. 2004

Phytotherapy Research

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Fractionation of extracts of the leaves of Melicope borbonica (syn. Euodia borbonica var. borbonica), a medicinal plant from the Réunion Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against Candida albicans and Penicillium expansum, in accordance with the traditional use of the plant. Moreover, 2,4,6-trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7-(3-methyl-2-butenyloxy)-6-methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (alpha-curcumene and 3,6-epidioxy-1,10-bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antiin fl ammatory activity in vitro. No alkaloids were detected.

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Section: Resultssupporting

confidence: 95%

Antifungal constituents of Melicope borbonica

Simonsen

Adsersen

Bremner

et al. 2004

Phytotherapy Research

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“…The tested compounds were effective against C. albicans, M. canis, T. rubrum, A. flavus, A. parasiticum and Penicillium. However, the xanthoxylin isolated from leaves and stems of Sebastiania schottiana displayed the highest activity against M. canis (72-T) with MIC and MFC values of 31.2 and 62.5 µg/ml, respectively [79].…”

Section: Xanthoxylinmentioning

confidence: 99%

Standardization of Chromolaena Odorata, Kaempferia Parviflora and Zanthoxylum Piperitum

Pitakpawasutthi

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Chromolaena odorata (L.) R.M. King & H. Rob. or Sabsue is a species in family Asteraceae. In Thailand, it is locally used to treat skin diseases, diabetes, as well as insect bites. Kaempferia parviflora Wall. ex Baker or Krachai Dum belongs to Zingiberaceae family. In herbal medicine, it is generally used to promote health, to cure gastrointestinal disorder and anti-inflammation. Zanthoxylum piperitum (L.) DC., belonging to the Rutaceae family, is known in Thai name as Prig Horm. All parts of Z. piperitum are used to treat abdominal pain, vomiting and diarrhea. Chlorogenic acid, 5,7-dimethoxyflavone and xanthoxylin are the active components in C. odorata leaves, K. parviflora rhizomes and Z. piperitum fruits respectively and these compounds were used as a standard marker in this study. For quantitative analysis, the results indicated that the chlorogenic acid, 5,7-dimethoxyflavone and xanthoxylin contents quantified by TLC-densitometry and TLC image analysis were not statistically significantly different (P > 0.05). For in vitro biological activities, the results revealed that each extract and its active constituents showed its antioxidant and anti-diabetic potentials. K. parviflora rhizome showed potent toxicity whilst C. odorata leaf and Z. piperitum fruit ethanolic extract showed weak toxicity against brine shrimp nauplii. As the result of cell viability activity, all tested samples exhibited no significant cytotoxic activity against 5 human cancer and 1 normal cell lines. For GC-MS analysis, each plant samples showed its major components of essential oil. Furthermore, the pharmacognostic specification of K. parviflora rhizomes were established in order to provide macroscopic and microscopic evaluation, physico-chemical parameters and chemical fingerprints.

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