Further Distribution Studies on the Oxytocic Hormone of the Posterior Lobe of the Pituitary Gland and the Preparation of an Active Crystalline Flavianate

Pierce, John G.; Gordon, Samuel; Vigneaud, Vincent du

doi:10.1016/s0021-9258(18)38532-6

Cited by 68 publications

(6 citation statements)

References 13 publications

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“…Oxytocin is the neurohypophyseal peptide that is well known for its hormonal role in lactation and parturition and was discovered and synthesized together with the other neurohypophyseal peptide arginine-vasopressin in the 1950s by the Nobel Price Du Vigneaud and coworkers [ 1 , 2 ] (see Table 1 for the amino acid sequence of neurohypophyseal peptides and a few of their peptidic and non-peptidic analogues). Oxytocin is found in the same amount in female and male mammals in the magnocellular and parvocellular neurons, whose cell bodies are in the paraventricular (PVN) and supraoptic (SO) nuclei of the hypothalamus.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

Melis

Argiolas

2021

IJMS

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A continuously increasing amount of research shows that oxytocin is involved in numerous central functions. Among the functions in which oxytocin is thought to be involved are those that play a role in social and sexual behaviors, and the involvement of central oxytocin in erectile function and sexual behavior was indeed one of the first to be discovered in laboratory animals in the 1980s. The first part of this review summarizes the results of studies done in laboratory animals that support a facilitatory role of oxytocin in male and female sexual behavior and reveal mechanisms through which this ancient neuropeptide participates in concert with other neurotransmitters and neuropeptides in this complex function, which is fundamental for the species reproduction. The second part summarizes the results of studies done mainly with intranasal oxytocin in men and women with the aim to translate the results found in laboratory animals to humans. Unexpectedly, the results of these studies do not appear to confirm the facilitatory role of oxytocin found in male and female sexual behavior in animals, both in men and women. Possible explanations for the failure of oxytocin to improve sexual behavior in men and women and strategies to attempt to overcome this impasse are considered.

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Section: Introductionmentioning

confidence: 99%

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

Melis

Argiolas

2021

IJMS

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“…A solution of isobutyl chloroformate (0.65 ml, 5.0 mmol) in THF (3 ml) was added, and the mixture was stirred at -10°for 20 min. Dbt-OH-H20 (2.14 g, 6.00 mmol) and NMM (1.68 ml, 15.0 mmol) in H20 (6.5 ml) were added, and the solution was allowed to come to room temperature over a 90-min period. The solution was then acidified to pH 2 with concentrated HC1, and the THF was removed under reduced pressure.…”

Section: Methodsmentioning

confidence: 99%

[1-.beta.-Mercaptopropionic acid,2-(3,5-dibromo-L-tyrosine)]oxytocin, a potent inhibitor of oxytocin

Lundell¹,

Ferger²

1975

J. Med. Chem.

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[1-Beta-Mercaptopropionic acid,2-(3,5-dibromo-L-tyrosine)]oxytocin was synthesized from a protected polypeptide intermediate that had been prepared by the condensation of S-ethylcarbamoyl-beta-mercaptopropionyl-3,5-dibromotyrosine with H-Ile-Gln-Asn-Cys(Ec)-Pro-Leu-Gly-NH2, using dicyclohexylcarbodiimide in dimethylformamide. The ethylcarbamoyl (Ec) protecting groups were removed by refluxing NH3, and the resulting disulfhydryl peptide was oxidatively cyclized to the corresponding disulfide by ICH2CH2I. Purification of the analog was effected by partition chromatography and gel filtration. The analog possesses antioxytocic (pA2 = 7.05) and antiavian vasodepressor (pA2 = 7.44) activities but has neither agonist nor antagonist activity in the rat pressor assay.

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“…Since the discovery of the importance of peptides in living systems the field has dramatically expanded. The isolation 3 and synthesis 4 of oxytocin and subsequent structure elucidation of insulin 5 promoted an unprecedented impetus for the development of new and effective peptide synthesis procedures. 6 The concept of Merrifield's solid-phase peptide synthesis 7 is the most successful of the techniques and recently has been almost exclusively used for the rapid synthesis of peptides.…”

mentioning

confidence: 99%

Deprotection and cleavage of peptides bound to Merrifield resin by stable dimethyl ether–poly(hydrogen fluoride) (DMEPHF) complex. a new and convenient reagent for peptide chemistry

et al. 2002

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Further Distribution Studies on the Oxytocic Hormone of the Posterior Lobe of the Pituitary Gland and the Preparation of an Active Crystalline Flavianate

Cited by 68 publications

References 13 publications

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

[1-.beta.-Mercaptopropionic acid,2-(3,5-dibromo-L-tyrosine)]oxytocin, a potent inhibitor of oxytocin

Deprotection and cleavage of peptides bound to Merrifield resin by stable dimethyl ether–poly(hydrogen fluoride) (DMEPHF) complex. a new and convenient reagent for peptide chemistry

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