Further<i>in vitro</i>evaluation of antiradical and antimicrobial activities of phytol

Pejin, Boris; Savić, Aleksandar; Soković, Marina; Glamočlija, Jasmina; Ćirić, Ana; Nikolić, Miloš; Radotić, Ksenija; Mojović, Miloš

doi:10.1080/14786419.2013.869692

Cited by 141 publications

(88 citation statements)

References 29 publications

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“…Limonene present in appreciable amounts (5.66%) in our oil efficient in inhibiting the proliferation of a variety of microorganisms that cause food spoilage [49] . The antimicrobial activity of phytol against eight bacterial and eight fungal strains was investigated by Pejin et al [50] . It was proven that phytol to be active against all tested bacteria and fungi.…”

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confidence: 99%

Chemical Composition and Antifungal Activity of Essential Oil from Xanthium strumarium L. Leaves

Parveen¹,

Mazhar²,

Siddique³

et al. 2017

Journal of Pharmaceutical Sciences

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Parveen, et al.: Studies on Essential Oil of Xanthium strumarium L. LeavesThe hydrodistilled essential oil from Xanthium strumarium L. leaves was analysed by gas chromatographymass spectrometry. Nine out of twenty two constituents were identified from X. strumarium oil. The main components of the oil were β-caryophyllene (17.53%), α-cadinol (6.66%), spathulenol (6.09%), limonene (5.66%) and 1,3,5-trimethyl-2[2-nitroallyl]benzene (3.29%). Phytol (2.42%), α-muurolene (2.08%), copaene (1.47%) were present in appreciable amounts. E,E,Z-1,3,12-nonadecatriene-5,14-diol (0.27%) was present in minor amount. The oil displayed high degree of antifungal effect against all fungal strains with 11.8-46.0 mm zone of inhibition at concentration range 8-250 μg/ml. The 8 μg/ml minimum fungicidal concentration along with being the minimum inhibitory concentration points to the potential of X. strumarium essential oil as a promising source of antifungal agents with useful biomedical applications.

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confidence: 99%

Chemical Composition and Antifungal Activity of Essential Oil from Xanthium strumarium L. Leaves

Parveen¹,

Mazhar²,

Siddique³

et al. 2017

Journal of Pharmaceutical Sciences

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“…Otherwise, ROS coming from the substances may implicate DNA damage; one of them is the • OH which eventually binds with metal ions randomly distributes in the DNA; the ultimate result is the single strand break (SSB) [7], whichever also evident for oxidative DNA modification [13]. Pejin et al [14] suggested that PYL is a potent radical scavenger, which potentially scavenged…”

Section: Discussionmentioning

confidence: 99%

A Possible Phytol-cytoprotective Trait through Reactive Species-Induced Oxidative Stress Ebbing Pathway

Islam¹,

Santos²,

Ferreira³

et al. 2016

Int Arch Med

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This study aims at investigating a possible pathway of cytotoxicological status of the diterpenoid essential oil, phytol (PYL). For this brine shrimp lethality bioassay (BSLB) and hemolysis (HL) test systems were selected. In the BSLB, PYL either alone or co-treated with ethylenediaminetetraacetic acid (EDTA), potassium di-chromate (K 2 Cr 2 O 7 ; KD), copper sulphate (CuSO 4 .5H 2 O; CS) and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox, TRO) as membrane lyser, strong oxidizer, oxidizer-cytogenotoxicant and antioxidative-cell-protestant, respectively. The HL was carried out in rat erythrocytes (RBCs) taking TRO as a standard. In addition, to view a time-dependent cytotoxic activity of PYL, the mortality of the shrimps was counted at 24 and 48 h. Results suggest PYL is non-cytotoxic at low (40-160 µM) but toxic at high concentration (2-8 mM) to the shrimps and RBCs. An increased cytotoxicity was observed for 24 h to 48 h in brine shrimps. In both cases groups co-treated with cytotoxicants/protestant suggest that PYL is cytoprotective in the presence of oxidizer. The cytoprotectivityof PYL may be connected to its antioxidant potential and cytotoxicity for antioxidant-mediated pro-oxidative effects. In conclusion, PYL is cytoprotective at low concentration but toxic at high, activities found, however, may be linked to the radical scavenging pathway.

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“…20 Phytol is found common in both the species. Phytol is an important phytochemical compound having properties as an anxiolytic, anti-depressant, 21 anti-radical, 22 antibacterial, 23 anti-cancer, 24 anti-inflammatory. 25 Thus the abundant presence of phytol in leaves of Allophylus species suggests that these species may prove helpful in prevention of degeneartive diseases.…”

Section: Plate 2: Chromatogram Of Gcms Analysis Of Young Leaves a Sementioning

confidence: 99%

“…15 There are some reports on phytochemical studies of A. cobbe. Screening of leaves and barks of A. cobbe gave Phytol is used in the fragrance industry and used in cosmetics, shampoos, toilet soaps, household cleaners, and detergents [28] anti-cancer [24] antimicrobial [23] anti-radical [22] anti Abbrv-RT-Retention Time, %Conc.-percent concentration, MW-Molecular weight, MF-Molecular formula *-literature not found.…”

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confidence: 99%

GC-MS Analysis of Young Leaves of Allophylus cobbe (L.) Raeusch. and Allophylus serratus (Roxb.) Kurz.

Bharat¹,

Krishna²

2017

IJPER

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Background: Allophylus cobbe(L.) Raeusch. and Allophylus serratus (Roxb.)Kurz. (Sapindaceae) are medicinal plants traditionally used to cure bone fractures and other ailments in India. Objective: Present work was aimed at the identification of phytochemical compounds from young leaves of A. cobbe and A. serratus by applying gas chromatography mass spectrometry. Method: GC-MS technique was used for analysis of compounds. Results: It indicates 11 compounds from A. serratus and seven compounds from A. cobbe having mixture of terpenoids, alkanes and fatty acids. The major compounds found in A. cobbe were 1,1-diethoxy ethane (82.97%) (RT: 3.192min), phytol (7.07%) (RT: 43.690 min) and hexanoic acid (3.67%) (RT: 29.576 min) while in A. serratus 3-methyl butanol (53.16%) (RT: 3.223 min), 2-propenoic acid, 2-(dimethylamino) ethyl ester (27.08%) (RT: 13.94 min) and diisocytyl phthalate (4.49%) (RT: 52.584 min) were found in higher quantity. Phytol was detected from both species. Phytol possesses anti-radical, anti-cancer, antibacterial and anti-inflammatory properties as well as used in artificial synthesis of vitamin E and vitamin K in cosmetics and fragrance industry. Conclusion:The abundant presence of phytol in leaves of Allophylus species (7.07% in A. cobbe and 2.60% in A. serratus) suggests that these species may prove helpful in prevention of degenerative diseases and application of these herbs in cosmetics which may prove a cost effective natural alternative to current synthetic cosmetics. Presence of industrially important chemicals like phytol, 1,1-diethoxy ethane, hexanoic acid, diisocytyl phthalate, 2-propeonic acid, 2-(dimethylamino) ethyl ester underlines industrial importance of these species which needs further research on this aspect to focus in detail.

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Furtherin vitroevaluation of antiradical and antimicrobial activities of phytol

Cited by 141 publications

References 29 publications

Chemical Composition and Antifungal Activity of Essential Oil from Xanthium strumarium L. Leaves

Chemical Composition and Antifungal Activity of Essential Oil from Xanthium strumarium L. Leaves

A Possible Phytol-cytoprotective Trait through Reactive Species-Induced Oxidative Stress Ebbing Pathway

GC-MS Analysis of Young Leaves of Allophylus cobbe (L.) Raeusch. and Allophylus serratus (Roxb.) Kurz.

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