Further serological studies on fowl‐tumour viruses

Andrewes, C. H.

doi:10.1002/path.1700370105

Cited by 23 publications

(6 citation statements)

References 7 publications

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“…All fowl tumor viruses studied by Andrewes (1931Andrewes ( , 1933 were found to have some degree of antigenic relationship. Evidence, based on complement-fixation reactions, that both filterable and nonfilterable fowl tumors share a comon antigenic factor was reported by Dmochowski and Knox (1939).…”

Section: Chemically Induced Avian Sarcomasmentioning

confidence: 96%

Chemical Carcinogenesis in Birds. A Review

Crispens

1961

Poultry Science

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Section: Chemically Induced Avian Sarcomasmentioning

confidence: 96%

Chemical Carcinogenesis in Birds. A Review

Crispens

1961

Poultry Science

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“…These experiments suggest that most chickens immune to leukosis are resistant to the cell-free virus of Sarcoma 13 and that those that are susceptible are unable to deprive the virus of Strain 13 of its ability to produce erythroleukosis. The studies of Andrewes (12) indicate that immunity to the viruses of chicken tumors is not strictly specific. Further investigations are needed to determine whether resistance to a cell-free virus develops in birds with advancing age and whether it can be produced by inoculations with a heterologous v i r u s .…”

Section: Inoculation Of Chickens Immune To Leukosismentioning

confidence: 99%

“…In some animals that recover from sarcoma, or leukosis, or that have the disease in a chronic form, antibodies that neutralize the free oncogenic agent appear in the blood. The antibodies directed against the agents of sarcomata have been thoroughly investigated by Andrewes (12), who found that they possess some specificity in addition to a group effect. Antibodies active against the agents of leukosis, according to the few observations made (10,13), also exert group and specific effects.…”

Section: Neutralization Experimentsmentioning

confidence: 99%

The Relation of Leukosis to Sarcoma of Chickens

Stubbs

Fürth

1935

Journal of Experimental Medicine

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A transmissible strain of sarcoma (Strain 13) is described that took its origin in a chicken inoculated with leukosis of Strain 1. The virus of Strain 13 produces sarcoma in the breast muscle injected with it and after intravenous inoculation it produces diffuse sarcomatosis of the spleen, bone marrow, and several other organs. The available evidence suggests that Strain 13 is caused by a single virus with ability to produce diffuse endothelial growth in the blood-forming organs associated with extensive hematomata, and erythroblastic proliferation. The strain can be readily transmitted by material free from live cells and preserved by drying. As small amounts of blood as 0.00001 cc. from chickens with sarcomatosis of the internal organs transmit Strain 13 by the intravenous route. By implantation sarcoma of Strain 13 can be transferred to chickens that are resistant to repeated inoculations with leukotic viruses.

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“…MATERIALS AND METHODS Spontaneous regression of Rous sarcoma tumors in chickens have been reported by Andrewes (1933) and Greenwood et al (1948). The role of spontaneous regression as a genetically controlled defense mechanism against tumors was discussed by Gyles et al (1968).…”

Section: Introductionmentioning

confidence: 99%