Further studies on the antihepatotoxic activity of Phyllanthus maderaspatensis Linn.

Asha, V.V.; S, Akhila; Wills, P.J.; Subramoniam, A.

doi:10.1016/j.jep.2004.02.005

Cited by 42 publications

(30 citation statements)

References 8 publications

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“…Protection against paracetamol-induced toxicity has been used as a test for potential hepatoprotective activity by several investigations [26][27][28][29][30] . Liver is the most important and main part of the animal body.…”

Section: Resultsmentioning

confidence: 99%

Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Gupta¹,

Misra²

2006

American J. of Pharmacology and Toxicology

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Hepatoprotective activity of aqueous ethanolic extract of Chamomile recutita capitula against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of aqueous ethanolic extract of Chamomile recutita capitula on blood and liver glutathione, Na + K + -ATPase activity, serum marker enzymes, serum bilirubin, glycogen and thiobarbutiric acid reactive substances against paracetamol induced damage in rats have been studied to find out the possible mechanism of hepatoprotection. It was observed that extract of chamomile has reversal effects on the levels of above-mentioned parameters in paracetamol hepatotoxicity. The extract of capitula of chamomile functions as a hepatoprotective agent and this hepatoprotective activity of chamomile may be due normalization of impaired membrane function activity.

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Section: Resultsmentioning

confidence: 99%

Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Gupta¹,

Misra²

2006

American J. of Pharmacology and Toxicology

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“…However, as the time span between administration of phalloidine and start of treatment increased, the therapeutic activity of silymarin decreased as well, and after 30 min its 'antidote' effect was negligible. Silymarin has also been shown to be active in the treatment of hepatotoxicity [7,8]. In the study presented here, we compared the therapeutic action of silymarin and NAC as an antidote in mice after administering a lethal dose of APAP for 24 h. In the mouse, maximal toxicity following APAP occurred after approximately 6-8 h. As maximal toxicity occurred so early, the antidote administered after 24 h had no effect on the development of toxicity.…”

Section: Conflict Of Interestmentioning

confidence: 99%

Novel Use of Silymarin as Delayed Therapy for Acetaminophen-Induced Acute Hepatic Injury

Hau

Wong

Cheng

et al. 2010

Forsch Komplementmed

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Aim: Recently, we have demonstrated that silymarin has a comparable pharmaceutical activity as Phyllanthus urinaria extract when used to rescue mice from acetaminophen-induced acute liver injury. In the present study, we further compared the therapeutic action of silymarin with N-acetyl cysteine (commonly used in clinical practice for emergency treatments) as a rescuer in mice after administering a lethal dose of acetaminophen for 24 h. Methods: Acute liver injury was induced in the treatment groups by intraperitoneally administered acetaminophen at a dose of 550 mg/kg body weight on day 1. The control group received an equal volume of physiological saline intraperitoneally. From day 2 to 4, the treatment groups received various doses of silymarin or N-acetyl cysteine orally once daily, while the control group and the acetaminophen group received an equal volume of water orally. The mortality rate was recorded in all groups. On day 5, all mice were sacrificed for examination. Results: Silymarin greatly improved the counteracting effects on mortality rate as compared to N-acetyl cysteine. Conclusion: Silymarin should be further considered as an antidote for patients with acetaminopheninduced acute hepatic injury and delayed treatment.

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“…High level of GOT and GPT in blood can be an indicator of leakage from cells caused by damage of cell membrane. Hence, the evaluation of this two enzymes in blood is a routine procedure to evaluate and monitor the hepatocellular disorders or muscle damage (Asha, Akhila, Wills, Subramoniam, 2004;Yanpallewar et al, 2003;Yen, Wu, Lin, Lin, 2007). In the present results, the activities of GOT and GPT were increased by oral administration of acetaminophen, however the increased amplitude was much lower than in rodents administered a similar dose (Oliveira et al, 2005) or even a smaller dose (Knight and Jaeschke, 2002).…”

Section: Discussionmentioning

confidence: 99%

Effects of acetaminophen administration on liver histopathology, serum GOT/GPT levels and circulating microRNA-122 concentration in olive flounder (Paralichthys olivaceus)

Abdellaoui¹,

Kim²,

Kim³

2016

Journal of fish pathology

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Further studies on the antihepatotoxic activity of Phyllanthus maderaspatensis Linn.

Cited by 42 publications

References 8 publications

Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Hepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino Rats

Novel Use of Silymarin as Delayed Therapy for Acetaminophen-Induced Acute Hepatic Injury

Effects of acetaminophen administration on liver histopathology, serum GOT/GPT levels and circulating microRNA-122 concentration in olive flounder (Paralichthys olivaceus)

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