Future Approaches of Nanomedicine in Clinical Science

Brewer, Mary; Zhang, Tierui; Dong, Wenjun; Rutherford, Michael; Tian, Zheng

doi:10.1016/j.mcna.2007.05.006

Cited by 21 publications

(17 citation statements)

References 163 publications

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“…Promoted by the National Institutes of Health of the United States, nanomedical research is providing easy access to innovative nanodevices and nanosystems based on the rational design and precise integration of functional nanomaterials for the further development of clinical nanomedicine [42] . Nanotechnology will enable design and delivery of more effective drugs with targeted delivery increasing efficacy and reducing toxicity.…”

Section: Future Potential Of Nanomedicinementioning

confidence: 99%

Nanomedicine: Application of Nanobiotechnology in Medical Practice

Jain¹

2008

Med Princ Pract

209

126

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Nanomedicine is the application of nanobiotechnologies to medicine. This article starts with the basics of nanobiotechnology, followed by its applications in molecular diagnostics, nanodiagnostics, and improvements in the discovery, design and delivery of drugs, including nanopharmaceuticals. It will improve biological therapies such as vaccination, cell therapy and gene therapy. Nanobiotechnology forms the basis of many new devices being developed for medicine and surgery such as nanorobots. It has applications in practically every branch of medicine and examples are presented of those concerning cancer (nanooncology), neurological disorders (nanoneurology), cardiovascular disorders (nanocardiology), diseases of bones and joints (nanoorthopedics), diseases of the eye (nanoophthalmology), and infectious diseases. Safety issues of in vivo use of nanomaterials are also discussed. Nanobiotechnology will facilitate the integration of diagnostics with therapeutics and facilitate the development of personalized medicine, i.e. prescription of specific therapeutics best suited for an individual. Many of the developments have already started and within a decade a definite impact will be felt in the practice of medicine.

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Section: Future Potential Of Nanomedicinementioning

confidence: 99%

Nanomedicine: Application of Nanobiotechnology in Medical Practice

Jain¹

2008

Med Princ Pract

209

126

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“…Conjugation of pharmaceuticals to dendrimers, or artificial proteins, achieves similar results, and with the addition of site-specific surface antibodies, also allows for targeted drug delivery, resulting in decreased systemic adverse effects [16]. This strategy has demonstrated efficacy in the treatment of arthritis in rats utilizing conjugated indomethacin, with sites of inflammation targeted by a factor of 2.29 compared with unconjugated indomethacin [18]. Overall, application of nanotechnology to pharmacotherapy (e.g., analgesic, antibiotic, thrombolytic, etc.)…”

Section: Pharmacotherapymentioning

confidence: 99%

Application of nanomedicine in emergency medicine; Point-of-care testing and drug delivery in twenty - first century

Pourmand

Wang

et al. 2012

DARU J Pharm Sci

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The application of emerging nanotechnology to the practice of medicine represents a frontier of nanomedicine. Nanomedicine has been defined as a science which emphasizes the use of nanoscale tools in conjunction with background knowledge of the human body for medical diagnosis and treatment. Application of nanomedicine in EM may give EM providers the opportunity to diagnose and treat life-threatening diseases in a shorter period of time. These applications include diagnostic utilities, preventive medicine, targeted pharmacotherapy, and tissue regeneration.

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“…Namgung et al (2011) observed that SNT functionalized with a complexing agent (branched polyethylenimine) enhanced MRI signals in addition to appreciable cellular uptake . In vivo imaging can be performed by the use of imaging techniques that already exist, including single photon emission CT (SPECT), positron emission tomography (PET), MRI, fl uorescence microscopy, CT and ultrasound (Brewer et al ., 2007). Also, silica nanoparticles with modifi ed fl uorescent dyes have been shown to be effective in immunostaining and in vivo imaging (Liu et al ., 2010b).…”

Section: Imagingmentioning

confidence: 99%