GABA tea prevents cardiac fibrosis by attenuating TNF-alpha and Fas/FasL-mediated apoptosis in streptozotocin-induced diabetic rats

Cherng, Shur Hueih; Huang, Chih Yang; Kuo, Wei Wen; Lai, Shue Er; Tseng, Chien Yu; Lin, Yueh Min; Tsai, Fuu Jen; Wang, Hsueh Fang

doi:10.1016/j.fct.2013.12.022

Cited by 29 publications

(14 citation statements)

References 48 publications

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“…EGCG is a major and functionally important catechin in tea extracts possessing powerful antioxidant and ROS scavenging activity . Previous reports from our laboratory have also revealed evidences to show the efficacy of EGCG from natural extracts to establish protection against oxidative stress . EGCG has shown significant protective effect against oxidative damages and endothelial dysfunction inflicted by oxidized LDL by suppressing ROS generation and by regulating MAPK pathway .…”

Section: Discussionmentioning

confidence: 85%

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p‐JNK mediated hypertrophy and enhancing P‐IGF1R, p‐akt, and p‐Bad^ser136 activity and by fortifying NRF2 antioxidation system

Shibu

Kuo

Chen

et al. 2017

Environmental Toxicology

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Tea, the most widely consumed natural beverage has been associated with reduced mortality risk from cardiovascular disease. Oolong tea is a partially fermented tea containing high levels of catechins, their degree of oxidation varies between 20%-80% causing differences in their active metabolites. In this study we examined the effect of oolong tea extract (OTE) obtained by oxidation at low-temperature for short-time against hypoxic injury and found that oolong tea provides cyto-protective effects by suppressing the JNK mediated hypertrophic effects and by enhancing the innate antioxidant mechanisms in neonatal cardiomyocytes and in H9c2 cells. OTE effectively attenuates 24 h hypoxia-triggered cardiomyocyte loss by suppressing caspase-3-cleavage and apoptosis in a dose-dependent manner. OTE also enhances the IGFIR/p-Akt associated survival-mechanism involving the elevation of p-Bad in a dose-dependent manner to aid cellular adaptations against hypoxic challenge. The results show the effects and mechanism of Oolong tea to provide cardio-protective benefits during hypoxic conditions.

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Section: Discussionmentioning

confidence: 85%

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p‐JNK mediated hypertrophy and enhancing P‐IGF1R, p‐akt, and p‐Bad^ser136 activity and by fortifying NRF2 antioxidation system

Shibu

Kuo

Chen

et al. 2017

Environmental Toxicology

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“…2 and 3). Further, HSP27 is thought to be inhibitory against Fas-induced apoptosis (18)(19)(20) . Interestingly, the GMNL-263 treatments in the high-fat diet-fed hamsters increased HSP27 in a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Supplementary heat-killed Lactobacillus reuteri GMNL-263 ameliorates hyperlipidaemic and cardiac apoptosis in high-fat diet-fed hamsters to maintain cardiovascular function

Wei

Kuo

et al. 2015

Br J Nutr

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Obesity and hyperlipidaemia increase the risk of CVD. Some strains of probiotics have been suggested to have potential applications in cardiovascular health by lowering serum LDL-cholesterol. In this work, high-fat diet-induced hyperlipidaemia in hamsters was treated with different doses (5 × 10 8 and 2·5 × 10 9 cells/kg per d) of heat-killed Lactobacillus reuteri GMNL-263 (Lr263) by oral gavage for 8 weeks. The serum lipid profile analysis showed that LDL-cholesterol and plasma malondialdehyde (P-MDA) were reduced in the GMNL-263 5 × 10 8 cells/kg per d treatment group. Total cholesterol and P-MDA were reduced in the GMNL-263 2·5 × 10 9 cells/kg per d treatment group. In terms of heart function, the GMNL-263 2·5 × 10 9 cells/kg per d treatments improved the ejection fraction from 85·71 to 91·81 % and fractional shortening from 46·93 to 57·92 % in the high-fat diet-fed hamster hearts. Moreover, the GMNL-263-treated, high-fat diet-fed hamster hearts exhibited reduced Fas-induced myocardial apoptosis and a reactivated IGF1R/PI3K/Akt cell survival pathway. Interestingly, the GMNL-263 treatments also enhanced the heat-shock protein 27 expression in a dose-dependent manner, but the mechanism for this increase remains unclear. In conclusion, supplementary heat-killed L. reuteri GMNL-263 can slightly reduce serum cholesterol. The antihyperlipidaemia effects of GMNL-263 may reactivate the IGF1R/PI3K/Akt cell survival pathway and reduce Fas-induced myocardial apoptosis in high-fat diet-fed hamster hearts.Key words: Hyperlipidaemia: LDL-cholesterol: Lactobacillus reuteri GMNL-263 (Lr263): Heart protection It was recently proven that cumulative exposure to hyperlipidaemia during early adulthood increases the risk of CVD in a dose-dependent manner (1) . In fact, prolonged exposure to decreased LDL-cholesterol beginning in early life significantly reduces the risk of CVD (2) .Recently, some strains of probiotics, such as multi-strain probiotic capsules (Streptococcus thermophilus, Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium lactis, Bifidobacterium longum and Bifidobacterium breve), were reported to significantly reduce serum cholesterol, waist circumference and body weight in adults with a BMI > 25 kg/m 2 during an 8-week treatment (3,4) . In addition, Lactobacillus reuteri NCIMB 30242, a probiotic associated with cardiovascular health, claims to clinically lower LDL-cholesterol levels by 11·6 % in hyperlipidaemic adults, and it has been approved by Health Canada (5,6) .

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“…Ventricular fibrosis was measured as previously described [ 11 ]. Briefly, left ventricle that had been separated from the whole heart organ and analyzed for morphometric measurements was fixed in formalin 10% solution.…”

Section: Methodsmentioning

confidence: 99%

Methanolic Extract of Ceplukan Leaf (Physalis minimaL.) Attenuates Ventricular Fibrosis through Inhibition of TNF-αin Ovariectomized Rats

Lestari

Permatasari

Rohman

2016

Advances in Pharmacological Sciences

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The increase of heart failure prevalence on menopausal women was correlated with the decrease of estrogen level. The aim of this study is to investigate the effects of ceplukan leaf (Physalis minima L.), which contains phytoestrogen physalin and withanolides, on ventricular TNF-α level and fibrosis in ovariectomized rats. Wistar rats were divided into six groups (control (—); OVX 5: 5-week ovariectomy (OVX); OVX 9: 9-week ovariectomy; treatments I, II, and III: 9-weeks OVX + 4-week ceplukan leaf's methanolic extract doses 500, 1500, and 2500 mg/kgBW, resp.). TNF-α levels were measured with ELISA. Fibrosis was counted as blue colored tissues percentage using Masson's Trichrome staining. This study showed that prolonged hypoestrogen increases ventricular fibrosis (p < 0.05). Ceplukan leaf treatment also resulted in a decrease of ventricular fibrosis and TNF-α level in dose dependent manner compared to without treatment group (p < 0.05). Furthermore, the TNF-α level was normalized in 2500 mg/kgBW Physalis minima L. (p < 0.05) treatment. The reduction of fibrosis positively correlated with TNF-α level (p < 0.05, r = 0.873). Methanolic extract of ceplukan leaf decreases ventricular fibrosis through the inhibition of ventricular TNF-α level in ovariectomized rats.

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GABA tea prevents cardiac fibrosis by attenuating TNF-alpha and Fas/FasL-mediated apoptosis in streptozotocin-induced diabetic rats

Cited by 29 publications

References 48 publications

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p‐JNK mediated hypertrophy and enhancing P‐IGF1R, p‐akt, and p‐Bad^ser136 activity and by fortifying NRF2 antioxidation system

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p‐JNK mediated hypertrophy and enhancing P‐IGF1R, p‐akt, and p‐Bad^ser136 activity and by fortifying NRF2 antioxidation system

Supplementary heat-killed Lactobacillus reuteri GMNL-263 ameliorates hyperlipidaemic and cardiac apoptosis in high-fat diet-fed hamsters to maintain cardiovascular function

Methanolic Extract of Ceplukan Leaf (Physalis minimaL.) Attenuates Ventricular Fibrosis through Inhibition of TNF-αin Ovariectomized Rats

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GABA tea prevents cardiac fibrosis by attenuating TNF-alpha and Fas/FasL-mediated apoptosis in streptozotocin-induced diabetic rats

Cited by 29 publications

References 48 publications

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p‐JNK mediated hypertrophy and enhancing P‐IGF1R, p‐akt, and p‐Badser136 activity and by fortifying NRF2 antioxidation system

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p‐JNK mediated hypertrophy and enhancing P‐IGF1R, p‐akt, and p‐Badser136 activity and by fortifying NRF2 antioxidation system

Supplementary heat-killed Lactobacillus reuteri GMNL-263 ameliorates hyperlipidaemic and cardiac apoptosis in high-fat diet-fed hamsters to maintain cardiovascular function

Methanolic Extract of Ceplukan Leaf (Physalis minimaL.) Attenuates Ventricular Fibrosis through Inhibition of TNF-αin Ovariectomized Rats

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Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p‐JNK mediated hypertrophy and enhancing P‐IGF1R, p‐akt, and p‐Bad^ser136 activity and by fortifying NRF2 antioxidation system

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p‐JNK mediated hypertrophy and enhancing P‐IGF1R, p‐akt, and p‐Bad^ser136 activity and by fortifying NRF2 antioxidation system