Gabapentin enhances the antinociceptive effect of intrathecal morphine in refractory cancer pain patients

Risk of major adverse events associated with gabapentinoid and opioid combination therapy: A systematic review and meta-analysis

“…After 179 relevant articles were assessed for eligibility through a full-text evaluation, 43 studies with 6,537,444 patients were selected. TRAEs were reported in 26 RCTs ( Caraceni et al, 2004 ; Gilron et al, 2005 ; Fassoulaki et al, 2006 ; Turan et al, 2006 ; Keskinbora et al, 2007 ; Clarke et al, 2009 ; Gatti et al, 2009 ; Clendenen et al, 2010 ; Rapchuk et al, 2010 ; Pesonen et al, 2011 ; Yucel et al, 2011 ; Chaparro et al, 2012 ; Jain et al, 2012 ; Pota et al, 2012 ; Yadeau et al, 2012 ; Mercadante et al, 2013 ; Paul et al, 2013 ; Clarke et al, 2015 ; Chen et al, 2016 ; Dou et al, 2017 ; Wang et al, 2017 ; Hah et al, 2018 ; Jones et al, 2019 ; Hermann et al, 2020 ; Jung et al, 2020 ; Teng et al, 2021 ) and 7 non-RCTs ( Caraceni et al, 1999 ; Li et al, 2010 ; Savelloni et al, 2017 ; Peckham et al, 2018 ; Bykov et al, 2020 ; Chae et al, 2021 ; Dai et al, 2021 ); mortality was reported in 10 non-RCTs. ( Abrahamsson et al, 2017 ; Gomes et al, 2017 ; Gomes et al, 2018 ; Slavova et al, 2018 ; Macleod et al, 2019 ; Lynn et al, 2020 ; Waddy et al, 2020 ; Bishop-Freeman et al, 2021 ; Mariottini et al, 2021 ; Chen et al, 2022 ).…”

“…The mean age of the participants in each study ranged between 34.1 and 79.6 years. The indications included perioperative pain (13 studies), ( Fassoulaki et al, 2006 ; Turan et al, 2006 ; Clarke et al, 2009 ; Clendenen et al, 2010 ; Rapchuk et al, 2010 ; Pesonen et al, 2011 ; Yucel et al, 2011 ; Chaparro et al, 2012 ; Jain et al, 2012 ; Yadeau et al, 2012 ; Paul et al, 2013 ; Clarke et al, 2015 ; Hah et al, 2018 ) cancer-related pain (7 studies), ( Caraceni et al, 2004 ; Keskinbora et al, 2007 ; Mercadante et al, 2013 ; Chen et al, 2016 ; Dou et al, 2017 ; Hermann et al, 2020 ; Teng et al, 2021 ) and non-cancer chronic pain (6 studies) ( Gilron et al, 2005 ; Gatti et al, 2009 ; Pota et al, 2012 ; Wang et al, 2017 ; Jones et al, 2019 ; Jung et al, 2020 ).…”

“…RCTs(Caraceni et al, 2004;Gilron et al, 2005;Fassoulaki et al, 2006;Turan et al, 2006;Keskinbora et al, 2007;Clarke et al, 2009;Gatti et al, 2009;Clendenen et al, 2010;Rapchuk et al, 2010;Pesonen et al, 2011;Yucel et al, 2011;Chaparro et al, 2012;Jain et al, 2012;Pota et al, 2012;Yadeau et al, 2012;Mercadante et al, 2013;Paul et al, 2013;Clarke et al, 2015;Chen et al, 2016;Dou et al, 2017;Wang et al, 2017;Hah et al, 2018; Jones et al, 2019;Hermann et al, 2020;Jung et al, 2020;Teng et al, 2021) and 7 non-RCTs(Caraceni et al, 1999;Li et al, 2010;Savelloni et al, 2017;Peckham et al, 2018;Bykov et al, 2020;Chae et al, 2021;Dai et al, 2021); mortality was reported in 10 non-RCTs (Abrahamsson et al, 2017;Gomes et al, 2017; . Frontiers in Pharmacology frontiersin.org…”

In patients with non-neuropathic cancer-related pain, does gabapentin provide additional palliative pain control as an adjunct to opioid therapy?

“…A 2021 prospective cohort study (n=74) examined the analgesic efficacy and adverse effects of combining oral gabapentin with intrathecal morphine compared with intrathecal morphine monotherapy. 2 Researchers included adults in China undergoing intrathecal delivery system for cancer pain of at least an eight on a 0-10 numerical rating scale (NRS) related to multiple types of cancer, including lung, pancreatic, colon, and gastric. Exclusion criteria were current gabapentin or pregabalin use, current chemotherapy or radiotherapy, or severe kidney disease.…”