Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent

Grishin, Alexander M.; Jalalian, Abolfazl; Tsindlekht, M. I.

doi:10.1063/1.4919810

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…A Summary of nanomaterials for enhancing EBRT. Element Materials References Gold Au nanoparticles/nanorods/nanoshells [31][32][33][34][35][36][37][38][39] Au loaded polymeric nanocapsules [40][41][42][43] Au nanomolecules [40,44,45] Active targeting Au nanoparticles [44,[46][47][48][49][50] Rare earth element Gadolinium oxide; Gd doped carbon dots; Gd doped calcium phosphate [51][52][53][54] Upconversion nanoparticles (e.g.NaYbF 4 [82][83][84] Pt nanoparticles [85,86] Ag nanoparticles; Fe 3 O 4/ Ag nanocomposite [87][88][89][90][91] Non high-Z elements Iron oxide nanoparticles [92][93][94] TiO 2 nanoparticles/nanotubes [95,96] Si nanoparticles [97,98] www.advmat.de www.advancedsciencenews.com (1.9 nm) -loaded polymeric micelles that exhibited longer blood circulation and 6-fold increase in tumor uptake, compared to that of ultrasmall Au nanoparticles...…”

Section: Doi: 101002/adma201700996mentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

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Section: Doi: 101002/adma201700996mentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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“…The additional peak at 369 cm –1 appearing in the GDC-30 is the signature peak of the Gd 2 O 3 structure . In addition, a peak at 440 cm –1 also confirmed the presence of Gd 2 O 3 in the GDC-30 sample. − This indicates that a second phase has formed in the GDC-30 sample.…”

Section: Resultsmentioning

confidence: 79%

Effect of Intrinsic and Extrinsic Oxygen Vacancies on the Conductivity of Gd-Doped CeO₂ Synthesized by a Sonochemical Route

2022

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The present study reports the effect of a dopant (gadolinium, Gd) on the grain size, generation of oxygen vacancies, and conductivity in ceria. Undoped and doped ceria (Ce 1−x Gd x O 2−δ , x = 0, 0.10, 0.20, and 0.30) are synthesized by the ultrasound-assisted sol−gel combustion method, followed by sintering at 1450 °C for 4 h. X-ray diffraction studies confirm the formation of the cubic fluorite phase. The lattice parameter variation confirms that the solid solubility limit of present samples lies between x = 0.20 and x = 0.30. The crystallite size of the powders ranges between 5 and 30 nm. The morphology of sintered materials is studied using scanning electron microscopy. Raman spectroscopy is used to investigate the presence of different structural defects and oxygen vacancies in undoped and Gd-doped ceria (CeO 2 ) samples. It also helped to detect the secondary phase formed in the GDC-30 sample. Ce 0.9 Gd 0.1 O 2−δ with a uniform, dense morphology and the presence of oxygen vacancies has the highest electrical conductivity (1.67 × 10 −2 S cm −1 at 600 °C). It could be a suitable material for electrolytes in solid-oxide fuel cells.

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“…2c) performed using the standard software option of the spectrometer showed peaks with a Gaussian distribution located at 1273, 1462, 1600, 1845, and 2111 cm -1 . Comparing literature data, it was found that the modes at 1273, 1845, and 2111 cm -1 are associated with Raman vibrations of the Gd-O structure [13][14][15]. Whereas, the peaks at 1462 and 1600 cm -1 refer to vibrations of Si scattering of the third order due to optical phonons (TO) [14][15][16] and vibrations of interstitial oxygen (O 2 ), respectively [15][16][17].…”

Section: Eejp 3 (2023)mentioning

confidence: 87%

Investigation of Defect Formation in Silicon Doped with Silver and Gadolinium Impurities by Raman Scattering Spectroscopy

Utamuradova,

Daliev,

Naurzalieva

et al. 2023

East Eur. J. Phys.

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Silicon doped with gadolinium and silver impurities were studied using a Renishaw InVia Raman spectrometer. Registration and identification of both crystalline and amorphous phase components in the samples was carried out. Some changes are observed in the Raman spectra of gadolinium-doped silicon samples compared to the initial sample. It has been experimentally found that an increase in the silver impurity concentration in gadolinium-doped silicon leads to a smoothing of the Raman spectrum, which indicates the formation of a more perfect crystal structure.

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Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent

Cited by 9 publications

References 11 publications

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Effect of Intrinsic and Extrinsic Oxygen Vacancies on the Conductivity of Gd-Doped CeO₂ Synthesized by a Sonochemical Route

Investigation of Defect Formation in Silicon Doped with Silver and Gadolinium Impurities by Raman Scattering Spectroscopy

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Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent

Cited by 9 publications

References 11 publications

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Effect of Intrinsic and Extrinsic Oxygen Vacancies on the Conductivity of Gd-Doped CeO2 Synthesized by a Sonochemical Route

Investigation of Defect Formation in Silicon Doped with Silver and Gadolinium Impurities by Raman Scattering Spectroscopy

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Effect of Intrinsic and Extrinsic Oxygen Vacancies on the Conductivity of Gd-Doped CeO₂ Synthesized by a Sonochemical Route