Gadolinium-based cancer therapeutic liposomes for chemotherapeutics and diagnostics

Na, Kyunga; Lee, Seul A; Jung, Suk Hyun; Shin, Byung Cheol

doi:10.1016/j.colsurfb.2010.12.019

Cited by 26 publications

(29 citation statements)

References 27 publications

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“…28 Liposome was an ideal CAs carrier to clearly display the extent of cancer and monitors the treatment effect in real time. 29,30 In addition, previous research has suggested that CAs have better MRI contrast effect or stronger fluorescence intensity when the CAs were released from the nanoparticles. 31 In this account, a novel strategy by using an NIR laser to turn on CT/MRI/FI multimodal imaging and PTT was successfully developed, based on the self-quench property of IR820 at high concentrations and different contrast effect ability of Gd-DOTA in the inner and outer parts of liposomes.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Wu¹,

Wang²,

Lu³

et al. 2017

IJN

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The major challenge in current clinic contrast agents (CAs) and chemotherapy is the poor tumor selectivity and response. Based on the self-quench property of IR820 at high concentrations, and different contrast effect ability of Gd-DOTA between inner and outer of liposome, we developed “bomb-like” light-triggered CAs (LTCAs) for enhanced CT/MRI/FI multimodal imaging, which can improve the signal-to-noise ratio of tumor tissue specifically. IR820, Iohexol and Gd-chelates were firstly encapsulated into the thermal-sensitive nanocarrier with a high concentration. This will result in protection and fluorescence quenching. Then, the release of CAs was triggered by near-infrared (NIR) light laser irradiation, which will lead to fluorescence and MRI activation and enable imaging of inflammation. In vitro and in vivo experiments demonstrated that LTCAs with 808 nm laser irradiation have shorter T 1 relaxation time in MRI and stronger intensity in FI compared to those without irradiation. Additionally, due to the high photothermal conversion efficiency of IR820, the injection of LTCAs was demonstrated to completely inhibit C6 tumor growth in nude mice up to 17 days after NIR laser irradiation. The results indicate that the LTCAs can serve as a promising platform for NIR-activated multimodal imaging and photothermal therapy.

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Section: Introductionmentioning

confidence: 99%

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Wu¹,

Wang²,

Lu³

et al. 2017

IJN

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“…This could possibly be due to changes in the accessibility of water molecules to the Gd(III) centre when indomethacin is present. 3,42 However, in general the presence of indomethacin has little influence on the relaxivities. The co-encapsulation of Gd(DTPA) and indomethacin in electrospun core-shell fibers is hence a promising route for simultaneous colonic MRI and drug delivery.…”

Section: Proton Relaxivitiesmentioning

confidence: 99%

Theranostic Fibers for Simultaneous Imaging and Drug Delivery

Jin

Geraldes

et al. 2016

Mol. Pharmaceutics

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Abstract:New methods for creating theranostic systems with simultaneous encapsulation of therapeutic, diagnostic and targeting agents are much sought after. This work reports for the first time the use of coaxial electrospinning to prepare such systems in the form of core-shell fibers. Eudragit S100 was used to form the shell of the fibers, while the core comprised polyethylene oxide loaded with the magnetic resonance contrast agent Gd(DTPA) (Gd(III) diethylenetriaminepentaacetate hydrate) and indomethacin as a model therapeutic agent. The fibers had linear cylindrical morphologies with clear core-shell structures, as demonstrated by electron microscopy. X-ray diffraction and differential scanning calorimetry proved that both indomethacin and Gd(DTPA) were present in the fibers in the amorphous physical form. This is thought to be a result of intermolecular interactions between the different components, the presence of which was suggested by IR spectroscopy. In vitro dissolution tests indicated that the fibers could provide targeted release of the active ingredients through a combined mechanism of erosion and diffusion. The proton relaxivities for Gd(DTPA) released from the fibers into tris buffer increased (r 1 =5.03-10.13 s -1 mM -1 ; r 2 =8.28-14.96 s -1 mM -1 ) compared with fresh Gd(DTPA) (r 1 =4.37 s -1 mM -1 and r 2 =4.85 s -1 mM -1 ), proving that electrospinning has not diminished the contrast properties of the complex. The new systems reported herein thus offer a new platform for delivering therapeutic and imaging agents simultaneously to the colon.

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“…13, 20 To date, lipid and lipid-like nanoparticles have been applied to deliver a variety of therapeutic agents such as doxorubicin, paclitaxel, and carboplatin in combination with magnetic resonance imaging (MRI) contrast agents such as gadolinium (Gd) based contrast agents for tumor therapy and imaging. 21–24 Apart from traditional chemotherapeutic agents, plasmid DNA (pDNA) and small interfering RNA (siRNA) have also been co-loaded with MRI agents into lipid-like nanoparticles (LLNs). 25–27 For example, lipid-peptide nanocomplexes were employed to deliver both pDNA and Gd-chelated lipid to achieve real-time monitoring of gene therapy in the brain.…”

Section: Introductionmentioning

confidence: 99%

Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents

Luo

Zhang

et al. 2017

Nanoscale

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Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agent in order to express functional proteins and provide real-time visualization. TT3-Gd18 LLNs was identified as a lead formulation, which was able to encapsulate 91% of mRNA and 74% of Gd. This formulation showed comparable or slightly higher delivery efficiency of mRNA compared to the initial TT3 LLNs. Moreover, strong MRI signal was observed in cell pellets treated with TT3-Gd18 LLNs. More importantly, TT3-Gd18 LLNs demonstrated efficient delivery of mRNA and Gd contrast agent in vivo.

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Gadolinium-based cancer therapeutic liposomes for chemotherapeutics and diagnostics

Cited by 26 publications

References 27 publications

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Theranostic Fibers for Simultaneous Imaging and Drug Delivery

Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents

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