Gain of hTERC: a genetic marker of malignancy in oral potentially malignant lesions

Dorji, Tshering; Monti, Valentina; Fellegara, Giovanni; Gabba, Silvia; Grazioli, Vittorio; Repetti, Elena; Marcialis, Chiara; Peluso, Sergio; Ruzza, Davide Di; Neri, Fabrizio; Foschini, Maria Pia

doi:10.1016/j.humpath.2015.05.013

Cited by 25 publications

(13 citation statements)

References 20 publications

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“…Furthermore, our study results are not only in accordance with those of several other groups who have identified telomerase activity in the majority of malignant tumors, but also in line with those who have identified telomerase activity in proliferative diseases, predisposing the development of malignant tumors [28][29][30][31][32] .…”

Section: Discussionsupporting

confidence: 92%

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Telomerase activity associated with progression of cervical lesions in a group of Colombian patients

Castro-Duque¹,

Loango-Chamorro²,

Ruiz-Hoyos³

et al. 2015

Rev. Bras. Ginecol. Obstet.

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PURPOSE To analyze the relation between the cytological findings and telomerase activity (TA). METHODS Cervical samples were evaluated and classified according to the Bethesda System. Telomerase activity was measured total product generated values (TPG) using the TRAP assay (telomeric repeat amplification protocol); data were analyzed statistically using the χ2 test, with the level of significance set at p<0.05. RESULTS The study was conducted on 102 patients. Of these, 3.9% showed normal cytological findings, 8.8% showed cervicitis; 2% showed Atypical Squamous Cells of Undetermined Significance (ASCUS); 67.6% showed Low Grade Squamous Intraepithelial Lesion (LSIL); 11.8% showed High Grade Squamous Intraepithelial Lesion (H-SIL) and 5.9% showed Squamous Carcinoma. Among telomerase-positive samples, the TPG values were cervicitis

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Section: Discussionsupporting

confidence: 92%

“…Studies reporting a positive correlation between telomerase activity and pathologic degree of tumor [29][30] suggest that the cells with higher telomerase activity…”

Section: Discussionmentioning

confidence: 99%

Telomerase activity associated with progression of cervical lesions in a group of Colombian patients

Castro-Duque¹,

Loango-Chamorro²,

Ruiz-Hoyos³

et al. 2015

Rev. Bras. Ginecol. Obstet.

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“…While the majority of human tumors maintain telomeres by overexpressing the reverse transcriptase TERT, single nucleotide polymorphisms at the TERC locus are associated with telomere lengthening and an increased risk of developing high-grade glioma (Walsh et al, 2014). Furthermore, TERC copy number gain strongly predicts the progression of premalignant oral cavity neoplasms to invasive cancer (Dorji et al, 2015). Meanwhile, Marek’s disease virus efficiently induces T cell lymphomas in chickens by expressing a viral telomerase RNA to promote telomere lengthening (Trapp et al, 2006).…”

Section: Lncrna Drivers Of Cancer Phenotypesmentioning

confidence: 99%

Long Noncoding RNAs in Cancer Pathways

2016

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Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.

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“…Human telomerase reverse transcriptase (hTERT) and human telomerase RNA component (hTERC) are essential components of telomerase and have been suggested to play a critical role in tumor progression of several types of cancer. 69,70 Although the number of studies related to oral carcinogenesis are limited, Kim et al 71 demonstrated hTERT expression by using in situ reverse transcriptase-polymerase chain reaction in moderate and severe dysplasia and invasive OSCC, whereas no expression was observed in the normal epithelium and in mild dysplasia. In addition, progression to OSCC was observed in 90% of PPOELs harboring human telomerase RNA component (hTERC) gene gain, but only in 5% of cases with a normal copy number of the hTERC gene.…”

Section: Immortalizationmentioning

confidence: 99%

Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications

Nikitakis

Pentenero

Georgaki

et al. 2018

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. However, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge. Arguably, progress in the prevention and treatment of oral premalignancy and cancer will require improved understanding of the underlying molecular mechanisms, facilitating the discovery of diagnostic, prognostic, and predictive markers, as well as the identification of novel targeted therapeutics. This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered.

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Gain of hTERC: a genetic marker of malignancy in oral potentially malignant lesions

Cited by 25 publications

References 20 publications

Telomerase activity associated with progression of cervical lesions in a group of Colombian patients

Telomerase activity associated with progression of cervical lesions in a group of Colombian patients

Long Noncoding RNAs in Cancer Pathways

Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications

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