2022
DOI: 10.1002/chem.202201497
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Gaining Insights on the Interactions of a Class of Decorated (2‐([2,2′‐Bipyridin]‐6‐yl)phenyl)platinum Compounds with c‐Myc Oncogene Promoter G‐Quadruplex and Other DNA Structures

Abstract: Organometallic molecules offer some of the most promising scaffolds for interaction with G-quadruplex nucleic acids. We report the efficient synthesis of a family of organoplatinum(II) complexes, featuring a 2-([2,2'-bipyridin]-6-yl)phenyl tridentate (N ∧ N ∧ C) ligand, that incorporates peripheral side-chains aiming at enhancing and diversifying its interaction capabilities. These include a di-isopropyl carbamoyl amide, a morpholine ethylenamide, two enantiomeric proline imides and an oxazole. The binding aff… Show more

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Cited by 4 publications
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