Galactomannan of Delonix regia seeds reduces nociception and morphological damage in the rat model of osteoarthritis induced by sodium monoiodoacetate

Potential metabolites of Arecaceae family for the natural anti-osteoarthritis medicine: A review

“…An increased antinociceptive effect was observed with 30 g and 100 g doses of galactomannan from day 15 to the endpoint at day 56. Joint damage was also reduced in OA-affected animals following the administration of 100 g galactomannan, compared with the saline placebo group (5.9 ± 1.8 vs. 19.0 ± 1.8, respectively; P < 0.05) [ 105 ].…”

“… Sources/Species of Arecaceae Metabolites/Compounds Structure Anti-osteoarthritis Activities Ref. 1 Arenga pinnata , Borassus flabellifer , Nypa fruticans Polysaccharide/galactomannan Reduces the level of joint damage and pain in rats with induced osteoarthritis and has anti-inflammatory activity [ 105 ] 2 Borassus flabellifer , Nypa fruticans Fatty Acid/linolenic acid (omega 3) Improves symptoms and prevents the degenerative process in cartilage [ 108 , 109 ] Linoleic acid (omega 6) 3 Phoenix dactylifera , Areca catechu Flavonoid/quercetin Inhibits the production of interleukin (IL)-1β and TNF via the TLR-4/NF-kB pathway, suppresses the expression of matrix-degrading proteases and inflammatory mediators, promotes the production of cartilage anabolic factors in IL-1β-induced mouse chondrocytes, upregulates SOD and TIMP-1, downregulates MMP-13, and promotes osteoarthritis degeneration by attenuating the oxidative stress response and inhibiting cartilage extracellular matrix degradation. [ 112 , 113 ] Phoenix dactylifera , Areca catechu Luteolin Cytoprotective against oxidative injury, inflammatory response, and ECM degradation in primary murine chondrocytes through activation of the AMPK/Nrf2 and AMPK signaling pathways, protects rat chondrocytes stimulated by IL-1β and monosodium iodoacetate (MIA)-induced osteoarthritis model.…”

“…For example, galactomannan polysaccharide compounds found in sugar palm, palmyra palm, and nipa palm fruits can be developed in OA treatments. Galactomannan has anti-inflammatory and chondroprotective effects that can reduce cartilage degradation [ 105 , 143 ]. According to the research, protein-free galactomannan provides a better anti-OA result.…”

Galactomannan of Delonix regia seeds modulates cytokine expression and oxidative stress eliciting anti-inflammatory and healing effects in mice cutaneous wound

“…Delonix regia ( amboyant) is a Fabaceae tree used for urbanism around the world, and its seeds contain an easily extractable galactomannan possessing molar mass in the magnitude order of 10 5 g mol − 1 , and mannose:galactose in the range from 2:1 to 3.9:1 [13][14][15][16]. Hydrogels from D. regia galactomannan had been developed for usage and drug delivery system as scaffold for cell culture and soft tissue engineering in osteoarthritis [16][17][18]. For our knowledge there is a single report demonstrating the use of the Fabaceae galactomannan from Caesalpinia pulcherrima formulated for cutaneous wounds [18], however, the healing properties of D. regia galactomannan has not yet been investigated.…”