Galangin ameliorates cardiac remodeling via the MEK1/2–ERK1/2 and PI3K–AKT pathways

Wang, Hui‐Bo; Huang, Shuqi; Xu, Man; Yang, Jun; Yang, Jian; Liu, Ming‐Xin; Chen, Wan; Liao, Hai‐Han; Fan, Di; Tang, Qi‐Zhu

doi:10.1002/jcp.28216

Cited by 43 publications

(30 citation statements)

References 32 publications

(63 reference statements)

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“…Liao et al reported that myocardin expression is induced in cardiac hypertrophy, and its overexpression in neonatal rat cardiomyocytes induces hypertrophy (Liao et al, 2011). GA significantly ameliorated cardiac function and inhibited cardiac hypertrophy and fibrosis by disruption of PI3K-Akt-GSK3β and MEK1/ 2-ERK1/2-GATA4 signaling and via Ang II stimulation (Wang et al, 2013;Wang et al, 2019). According to the present findings, GA plays an important protective role in regulating cardiac fibrosis.…”

Section: Discussionsupporting

confidence: 74%

Galangin Attenuates Isoproterenol-Induced Inflammation and Fibrosis in the Cardiac Tissue of Albino Wistar Rats

Radhiga

Sundaresan

Kanimozhi³

et al. 2020

Front. Pharmacol.

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Galangin (GA) is an active flavonoid of the rhizome of Alpinia galanga that belongs to the ginger family. GA exhibit potent anti-inflammatory properties. Therefore, we evaluated the preventive effects of GA against isoproterenol (ISO)-induced inflammation and myocardial fibrosis in male albino Wistar rats. We found that GA (1 mg/kg b.wt.) pretreatment attenuated the ISO-mediated (5 mg/kg b.wt. for 14 consecutive days) elevation of heart rate, activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase-MB (CKMB) in the rat serum. We also noticed that GA prevented the ISO-mediated cardiac markers i.e. cardiac troponin T and I (cTnT and cTnI) expression in the serum of rats. Further, GA pretreatment prevented ISO-mediated lipid peroxidation and diminished blood pressure and loss of antioxidants status in the heart tissue of ISO treated rats. In addition, GA treatment modulates ISO-induced alterations the expressions of tissue inhibitor of metalloproteinases-1 (TIMP-1), p-AKT, glycogen synthase kinase-3β (p-GSK-3β) and peroxisome proliferators-activated receptor-γ (PPAR-γ) in the heart tissue. Furthermore, molecular analysis (PCR array and western blot) revealed that GA pretreatment prevented inflammation and fibrosis related gene expression pattern in ISO-induced rats. Taken together, the results indicate the cardioprotective effect of GA against ISO-induced inflammation and fibrosis. The antioxidant and anti-inflammatory potential of GA could be considered for its cardioprotective effect in the ISO-treated rats.

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Section: Discussionsupporting

confidence: 74%

Galangin Attenuates Isoproterenol-Induced Inflammation and Fibrosis in the Cardiac Tissue of Albino Wistar Rats

Radhiga

Sundaresan

Kanimozhi³

et al. 2020

Front. Pharmacol.

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“…Recently, Wang et al [86] have suggested that galangin may also protect against cardiac remodeling by decreasing inflammatory responses and apoptosis. Its action was associated with the inhibition of PI3K-Akt-GSK3β signaling pathways.…”

Section: Honey Phenolics and Cardiovascular Diseasesmentioning

confidence: 99%

Honey and Its Phenolic Compounds as an Effective Natural Medicine for Cardiovascular Diseases in Humans?

Olas

2020

Nutrients

103

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Honey is a sweet, viscous syrup produced by the honey bee (Apis mellifera). It is probably the first natural sweetener ever discovered, and is currently used as a nutritious food supplement and medicinal agent. The aim of the present mini-review is to summarize and update the current knowledge regarding the role of honey in CVDs based on various experimental models. It also describes the role of its phenolic compounds in treating CVDs. Many such phenolic and flavonoid compounds, including quercetin, kaempferol, apigenin, and caffeic acid, have antioxidant and anti-platelet potential, and hence may ameliorate cardiovascular diseases (CVDs) through various mechanisms, such as by decreasing oxidative stress and inhibiting blood platelet activation. However, as the phenolic content of a particular type of honey is not always known, it can be difficult to determine whether any observed effects on the human cardiovascular system may be associated with the consumption of honey or its constituents. Therefore, further experiments in this area are needed.

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“…MAPKs, including JNK, P38 and ERK1/2, are leading factors in GA attacks. Mitogen-activated protein kinase kinase4/7 (MKK4/7), mitogen-activated extracellular signal-regulated kinase1/2 (MEK1/2) and MKK3/6 are upstream kinases of JNK, ERK1/2 and P38, respectively [25][26][27]. In this study, RDN reduced the abnormal expression of MKK4, pMEK1/2, p-JNK and p-ERK1/2.…”

Section: Discussionmentioning

confidence: 68%

Anti-inflammation effects of the total saponin fraction from Dioscorea nipponica Makino on rats with gouty arthritis by influencing MAPK signalling pathway

Zhou

Sun

Liu

et al. 2020

BMC Complement Med Ther

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Background: Dioscorea nipponica Makino is widely used in traditional Chinese medicine to treat gouty arthritis. Methods: Sixty male Wistar rats were divided into six groups: the normal group, model group, colchicine group (COL) and three total saponin groups (RDN) (high dose [160 mg/kg], middle dose [80 mg/kg] and low dose [40 mg/ kg]). HE staining was used to detect the histopathologic changes of the synovial tissue of joint. Immunohistochemical method was used to detect the protein expressions of P-38, p-P38, JNK, p-JNK, ERK1/2, p-ERK1/2, MEK1/2, p-MEK1/2, MKK4, p-MKK4, ICAM1, VCAM1, and PPARγ in the synovial tissue of joint. Realtime PCR and WB methods were used to detect the mRNA and protein expressions of PPARγ and AdipoR2 in the synovial tissue of joint. The contents of CXCL1 and ADP in the blood serum were measured by Elisa method. Results: Our study showed that RDN could improve the situation of the synovial tissue, reduce the protein expressions of MKK4, p-MEK1/2, p-JNK, p-ERK1/2, ICAM1. They could also decrease the content of CXCL1 and increase the content of ADP in the blood serum. Conclusion: RDN has good effect of anti-inflammation. This is in part realized by influencing MAPK signalling pathway. It provides a new visual angle to reveal the mechanism of RDN to treat GA.

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Galangin ameliorates cardiac remodeling via the MEK1/2–ERK1/2 and PI3K–AKT pathways

Cited by 43 publications

References 32 publications

Galangin Attenuates Isoproterenol-Induced Inflammation and Fibrosis in the Cardiac Tissue of Albino Wistar Rats

Galangin Attenuates Isoproterenol-Induced Inflammation and Fibrosis in the Cardiac Tissue of Albino Wistar Rats

Honey and Its Phenolic Compounds as an Effective Natural Medicine for Cardiovascular Diseases in Humans?

Anti-inflammation effects of the total saponin fraction from Dioscorea nipponica Makino on rats with gouty arthritis by influencing MAPK signalling pathway

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