Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling

Huang, Yu‐Ting; Tsai, Ming-Shiun; Hsieh, Pei-Chi; Shih, Jheng-Hong; Wang, Tsu-Shing; Wang, Yichun; Lin, Ting‐Hui; Wang, Sue-Hong

doi:10.1016/j.taap.2017.05.034

Cited by 118 publications

(80 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Galangin is one of the flavonoids that is found in Alpinia officinarum and is used as a form of herbal medicine for a variety of ailments [ 8 , 9 ]. Galangin had been used for its antibacterial, anticancer, anti-obesity, and antioxidant activities [ 10 , 11 , 13 , 14 , 15 ]. Previous studies also indicated that galangin suppresses inflammation in LPS-induced macrophages via inhibiting phosphorylation of ERK [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies also indicated that galangin suppresses inflammation in LPS-induced macrophages via inhibiting phosphorylation of ERK [ 15 ]. Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation, and cell death through inhibition of the ERK and NF-κB signaling pathways [ 14 ]. Galangin inhibits osteoclastic bone destruction and osteoclastogenesis by inhibiting the phosphorylation of NF-κB in collagen-induced arthritis and bone marrow-derived macrophages [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Galangin is a member of the flavonol subclass of flavonoids, which are present at high concentrations in the rhizome of Alpinia officinarum and have been applied for traditional Chinese medicine for various diseases [ 8 , 9 ]. Galangin has been reported to have certain biological activities, including antibacterial [ 10 ], anticancer [ 11 ], anti-obesity [ 12 ], and antioxidant activities [ 13 , 14 ]. Previous studies also indicated that galangin suppresses LPS-induced inflammation in macrophages [ 15 ] and inhibited inflammation in cisplatin-induced nephrotoxicity [ 14 ], collagen-induced arthritis [ 16 ], mast cell-mediated allergic inflammation [ 17 ], LPS-induced acute lung injury [ 18 ], and ovalbumin-induced airway inflammation [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson’s Disease in Rats

Chen

Liu

Jiang

et al. 2017

IJMS

View full text Add to dashboard Cite

Parkinson’s disease (PD) is caused by the loss of dopaminergic (DA) neurons in the midbrain substantia nigra (SN). Neuroinflammation, which is marked by microglial activation, plays a very important role in the pathogenesis of PD. Pro-inflammatory mediators produced by activated microglia could damage DA neurons. Hence, the inhibition of microglial activation may provide a new approach for treating PD. Galangin has been shown to inhibit inflammation in a variety of diseases, but not PD. In this study, we aimed to investigate the anti-inflammatory effect of galangin and the underlying mechanisms in Lipopolysaccharide (LPS) induced PD models. We first examined the protective effect of galangin in the LPS-induced PD rat model. Specifically, we investigated the effects on motor dysfunction, microglial activation, and the loss of DA neurons. Then, galangin was used to detect the impact on the inflammatory responses and inflammatory signaling pathways in LPS-induced BV-2 cells. The in vivo results showed that galangin dose-dependently attenuates the activation of microglia, the loss of DA neurons, and motor dysfunction. In vitro, galangin markedly inhibited LPS-induced expression of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β), cyclooxygenase 2 (COX-2), and induced nitric oxide synthase (iNOS) via associating with the phosphorylation of c-JUN N-terminal Kinase (JNK), p38, protein kinase B (AKT), and nuclear factor κB (NF-κB) p65. Collectively, the results indicated that galangin has a role in protecting DA neurons by inhibiting microglial activation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson’s Disease in Rats

Chen

Liu

Jiang

et al. 2017

IJMS

View full text Add to dashboard Cite

show abstract

“…Paeonia lactiflora (Ma et al, ), Panax ginseng (Bak et al, ), and Coffea arabica (Cavin et al, ) are examples of such herbs. Apigenin (a flavonoid in some Apiaceae herbs; Sang et al, ), galangin (found in some Zingiberaceae rhizomes; Huang et al, ), glycybridin A & G ( Glycyrrhiza glabra ; K. Li et al, ), lycopene (Hedayati et al, ), and cyanidin (an anthocyanin found in different berry fruits; De Pascual‐Teresa, ) are a few examples of natural substances that have been reported to interact with Nrf2, potentially presenting health promoting properties.…”

Section: Introductionmentioning

confidence: 99%

“…Paeonia lactiflora , Panax ginseng (Bak et al, 2016), and Coffea arabica (Cavin et al, 2008) are examples of such herbs. Apigenin (a flavonoid in some Apiaceae herbs; Sang et al, 2017), galangin (found in some Zingiberaceae rhizomes; Huang et al, 2017), glycybridin A & G (Glycyrrhiza glabra; K. , lycopene (Hedayati et al, 2019), and cyanidin (an anthocyanin found in different berry fruits;…”

Section: Introductionmentioning

confidence: 99%

The neuroprotective activities of natural products through the Nrf2 upregulation

Tavakkoli

Iranshahi

Hasheminezhad

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

Nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) is a basic‐region leucine zipper transcription factor that regulates the expression of many Phase II detoxifying/antioxidant enzymes. Many natural products act on the Nrf2 pathway and exhibit their preventive and/or therapeutic effects by activating Nrf2 and subsequently antioxidant enzymes. In this article, we reviewed the research literature that described Nrf2 activation as a mechanism for the neuroprotective effect of natural products. Our results showed that the inhibition of Kelch‐like ECH‐associated protein 1 and the activation of different intracellular kinases that lead to Nrf2 phosphorylation were the main mechanisms of Nrf2 upregulation suggested for these the natural products. Although some natural compounds such as terpenoids and alkaloids were reported to protect the nervous system by Nrf2 activating, flavonoids and phenolic compounds represent the majority of the reported neuroprotective natural substances that activate Nrf2. We also evaluated the physiochemical properties of some of the same substances to predict their oral bioavailability and central nervous system penetration. The results showed that sulforaphane and berberine have good oral bioavailability and would be predicted to cross through blood–brain barrier (BBB) easily, whereas the flavonoids in general would be predicted to be less effective in BBB transition because of their relatively high polar surface area.

show abstract

Galangin promotes cell apoptosis through suppression of H19 expression in hepatocellular carcinoma cells

et al. 2020

View full text Add to dashboard Cite

show abstract

Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling

Cited by 118 publications

References 66 publications

Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson’s Disease in Rats

Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson’s Disease in Rats

The neuroprotective activities of natural products through the Nrf2 upregulation

Galangin promotes cell apoptosis through suppression of H19 expression in hepatocellular carcinoma cells

Contact Info

Product

Resources

About