Gallbladder Metastasis of Non-Small Cell Lung Cancer

Naßenstein, Kai; Kissler, Mark J.

doi:10.1159/000079096

Cited by 14 publications

(14 citation statements)

References 11 publications

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“…The gallbladder can be the site of distant metastasis from other primary cancer sites, with lung and melanoma being the most common metastatic tumors. 31,32 Studies examining the molecular changes in GBC have noted frequent mutations of p53 and K-ras. The reported prevalences of GBC harboring p53 mutations range from 35-92%.…”

Section: Risk Factors and Pathogenesismentioning

confidence: 99%

Diagnosis and Surgical Management of Gallbladder Cancer: A Review

Reid

Medina

Donohue

2007

Journal of Gastrointestinal Surgery

210

154

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Gallbladder cancer is one of the most lethal carcinomas and continues to pose many challenges for surgeons. Identifiable risk factors for carcinoma of the gallbladder include cholelithiasis, an anomalous pancreaticobiliary junction, and focal mucosal microcalcifications. Adenocarcinoma is the primary histologic type in most patients and the tumor is frequently associated with Kras and p53 mutations. Radiologic and endoscopic advances in endoscopic ultrasonography and magnetic resonance cholangiopancreatogram, plus helical computed tomography, have enhanced preoperative staging. Surgical options include cholecystectomy for disease limited to the mucosa (Tis/T1) or a radical cholecystectomy (subsegmental resection of segments IVB and V plus a hepatoduodenal ligament lymphadenectomy) for advanced disease without signs of distant metastasis (T2-4/N0-N2). Some surgeons have advocated more radical hepatic resection including extended right hepatectomy or central bisegmentectomy plus caudate lobectomy. Japanese surgeons have reported studies that included patients having a pancreaticoduodenectomy to improve distal ductal margins and lymphadenectomy for T3 and T4 cancers. These patients have a lower rate of local recurrence but no survival advantage. Options for adjuvant therapy remain limited. Radiation therapy with fluorouracil radiosensitization is the most commonly used postoperative treatments. Current trials are investigating the role of capecitabine, oxaliplatin, and bevacizumab in the management of gallbladder carcinoma.

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Section: Risk Factors and Pathogenesismentioning

confidence: 99%

Diagnosis and Surgical Management of Gallbladder Cancer: A Review

Reid

Medina

Donohue

2007

Journal of Gastrointestinal Surgery

210

154

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“…A 45-year old man developed symptomatic cholecystitis form a metastatic lesion with histological origin of non-small lung cancer [41]. In a second case report, a 69 year-old man with inoperable squamous cell carcinoma of the lung developed cholecystitis from a metastatic deposit from this malignancy [42].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Indications and recommended approach for surgical intervention of metastatic disease to the gallbladder

et al. 2010

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Metastatic disease to the gallbladder is unusual. The most common malignancy metastatic to the gallbladder is melanoma, followed by renal cell carcinoma (RCC) and breast cancer. Due to the unusual nature of the disease, there are no trials available for review. Thus, the management for these patients has been based on institutional experience and review of case series. The indications for surgical intervention for melanoma are metastatic disease discrete to the gallbladder and biliary symptoms, which are uncommon for melanoma, but might occur due to cystic duct obstruction culminating in cholecystitis. Laparoscopic cholecystectomy without a lymphadenectomy is emerging as the preferred approach for this metastatic deposit. The vast majority of patients with metastases to the gallbladder from RCC carry a good prognosis and a laparoscopic cholecystectomy should be considered. Patients with metastases to the gallbladder from the breast classically present with biliary symptoms and commonly undergo a laparoscopic cholecystectomy, which invariably demonstrates a deposit in the gallbladder from lobular breast cancer. In the present report, we review the indications for surgical intervention from various malignancies metastatic to the gallbladder and the current consensus for the laparoscopic approach from the diverse metastatic deposits to the gallbladder.

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“…2,3 A majority of secondary malignancies of the gallbladder do not cause clinical symptoms, and metastases of the gallbladder are usually reported as incidental postmortem findings. 3 In a series by Abrams et al, 1 incidental gallbladder metastases were found in 5.8% of 1000 autopsied patients with cancer and in 1.9% of 160 with lung cancer. In the present case, the metastatic lesion in the gallbladder was initially asymptomatic, and therefore could not be suspected before workup with PET/CT.…”

Section: Figurementioning

confidence: 96%

Unusual Gallbladder Metastasis From Non–Small-Cell Lung Cancer Detected by F-18 FDG PET/CT With Intravenous Contrast Enhancement

Jeong¹,

Yun²,

Hong³

et al. 2010

Clinical Nuclear Medicine

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The detection of metastatic disease is important in staging and treatment of lung cancer. Metastatic lung cancer to the gallbladder is rarely reported. We report a case of an initially asymptomatic gallbladder metastasis from lung cancer detected on F-18 FDG PET/CT with intravenous contrast material enhancement. We observed elevated F-18 FDG activity in the gallbladder on PET/CT and subsequently confirmed the diagnosis of metastasis with a percutaneous needle biopsy. F-18 FDG PET/CT can be a useful tool for the detection of an unusual or unsuspected metastasis in the staging of lung cancer.

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Gallbladder Metastasis of Non-Small Cell Lung Cancer

Cited by 14 publications

References 11 publications

Diagnosis and Surgical Management of Gallbladder Cancer: A Review

Diagnosis and Surgical Management of Gallbladder Cancer: A Review

Indications and recommended approach for surgical intervention of metastatic disease to the gallbladder

Unusual Gallbladder Metastasis From Non–Small-Cell Lung Cancer Detected by F-18 FDG PET/CT With Intravenous Contrast Enhancement

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